diff --git a/src/cmd/compile/internal/ssa/expand_calls.go b/src/cmd/compile/internal/ssa/expand_calls.go
index 3681af65997cf..180afab33b1c7 100644
--- a/src/cmd/compile/internal/ssa/expand_calls.go
+++ b/src/cmd/compile/internal/ssa/expand_calls.go
@@ -247,7 +247,7 @@ func expandCalls(f *Func) {
 			// i.e., the struct select is generated and remains in because it is not applied to an actual structure.
 			// The OpLoad was created to load the single field of the IData
 			// This case removes that StructSelect.
-			if leafType != selector.Type {
+			if leafType != selector.Type && !selector.Type.IsEmptyInterface() { // empty interface for #42727
 				f.Fatalf("Unexpected Load as selector, leaf=%s, selector=%s\n", leaf.LongString(), selector.LongString())
 			}
 			leaf.copyOf(selector)
diff --git a/test/fixedbugs/issue42727.go b/test/fixedbugs/issue42727.go
new file mode 100644
index 0000000000000..40081708b1516
--- /dev/null
+++ b/test/fixedbugs/issue42727.go
@@ -0,0 +1,23 @@
+// compile
+
+// Copyright 2020 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+// Ensure that late expansion correctly handles an OpLoad with type interface{}
+
+package p
+
+type iface interface {
+	m()
+}
+
+type it interface{}
+
+type makeIface func() iface
+
+func f() {
+	var im makeIface
+	e := im().(it)
+	_ = &e
+}