diff --git a/synthtool/gcp/templates/python_library/docs/multiprocessing.rst b/synthtool/gcp/templates/python_library/docs/multiprocessing.rst
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+.. note::
+
+   Because this client uses :mod:`grpcio` library, it is safe to
+   share instances across threads. In multiprocessing scenarios, the best
+   practice is to create client instances *after* the invocation of
+   :func:`os.fork` by :class:`multiprocessing.Pool` or
+   :class:`multiprocessing.Process`.