diff --git a/index.js b/index.js
index aea15b0..aca5fcc 100644
--- a/index.js
+++ b/index.js
@@ -3,6 +3,10 @@ var path = require('path');
 var endsInTs = /\.ts$/;
 var endsInTsx = /\.tsx$/;
 var endsInBabelJs = /\.babel\.[jt]s(x)$/;
+var endsInEsbuildJs = /\.esbuild\.js$/;
+var endsInEsbuildJsx = /\.esbuild\.jsx$/;
+var endsInEsbuildTs = /\.esbuild\.ts$/;
+var endsInEsbuildTsx = /\.esbuild\.tsx$/;
 
 var mjsStub = path.join(__dirname, 'mjs-stub');
 
@@ -71,11 +75,59 @@ var extensions = {
   '.coffee.md': ['coffeescript/register', 'coffee-script/register', 'coffeescript', 'coffee-script'],
   '.csv': 'require-csv',
   '.eg': 'earlgrey/register',
+  '.esbuild.js': {
+    module: 'esbuild-register/dist/node',
+    register: function(mod) {
+      mod.register({
+        extensions: ['.js'],
+        target: 'node' + process.version.slice(1),
+        hookMatcher: function(file) {
+          return endsInEsbuildJs.test(file);
+        },
+      });
+    },
+  },
+  '.esbuild.jsx': {
+    module: 'esbuild-register/dist/node',
+    register: function(mod) {
+      mod.register({
+        extensions: ['.jsx'],
+        target: 'node' + process.version.slice(1),
+        hookMatcher: function(file) {
+          return endsInEsbuildJsx.test(file);
+        },
+      });
+    },
+  },
+  '.esbuild.ts': {
+    module: 'esbuild-register/dist/node',
+    register: function(mod) {
+      mod.register({
+        extensions: ['.ts'],
+        target: 'node' + process.version.slice(1),
+        hookMatcher: function(file) {
+          return endsInEsbuildTs.test(file);
+        },
+      });
+    },
+  },
+  '.esbuild.tsx': {
+    module: 'esbuild-register/dist/node',
+    register: function(mod) {
+      mod.register({
+        extensions: ['.tsx'],
+        target: 'node' + process.version.slice(1),
+        hookMatcher: function(file) {
+          return endsInEsbuildTsx.test(file);
+        },
+      });
+    },
+  },
   '.esm.js': {
     module: 'esm',
     register: function(hook) {
       // register on .js extension due to https://github.com/joyent/node/blob/v0.12.0/lib/module.js#L353
-      // which only captures the final extension (.babel.js -> .js)
+      // which only captures the final extension (.esm.js -> .js)
       var esmLoader = hook(module);
       require.extensions['.js'] = esmLoader('module')._extensions['.js'];
     },
diff --git a/test/fixtures/esbuild.js/0/package.json b/test/fixtures/esbuild.js/0/package.json
new file mode 100644
index 0000000..b32c446
--- /dev/null
+++ b/test/fixtures/esbuild.js/0/package.json
@@ -0,0 +1,6 @@
+{
+  "dependencies": {
+    "esbuild": "^0.14.29",
+    "esbuild-register": "^3.3.2"
+  }
+}
diff --git a/test/fixtures/esbuild.js/0/test.esbuild.js b/test/fixtures/esbuild.js/0/test.esbuild.js
new file mode 100644
index 0000000..7e19ed6
--- /dev/null
+++ b/test/fixtures/esbuild.js/0/test.esbuild.js
@@ -0,0 +1,14 @@
+class Foo {
+  #x = 1
+  #y = 2
+}
+
+export default {
+  data: {
+    trueKey: true,
+    falseKey: false,
+    subKey: {
+      subProp: 1,
+    },
+  },
+};
diff --git a/test/fixtures/esbuild.jsx/0/package.json b/test/fixtures/esbuild.jsx/0/package.json
new file mode 100644
index 0000000..b32c446
--- /dev/null
+++ b/test/fixtures/esbuild.jsx/0/package.json
@@ -0,0 +1,6 @@
+{
+  "dependencies": {
+    "esbuild": "^0.14.29",
+    "esbuild-register": "^3.3.2"
+  }
+}
diff --git a/test/fixtures/esbuild.jsx/0/test.esbuild.jsx b/test/fixtures/esbuild.jsx/0/test.esbuild.jsx
new file mode 100644
index 0000000..8d81afb
--- /dev/null
+++ b/test/fixtures/esbuild.jsx/0/test.esbuild.jsx
@@ -0,0 +1,28 @@
+const React = {
+  createElement(Component) {
+    return Component()
+  }
+}
+
+class Foo {
+  #x = 1
+  #y = 2
+}
+
+function Bar() {
+  const foo = new Foo();
+
+  return foo;
+}
+
+const a = <Bar />
+
+export default {
+  data: {
+    trueKey: true,
+    falseKey: false,
+    subKey: {
+      subProp: 1,
+    },
+  },
+};
diff --git a/test/fixtures/esbuild.ts/0/package.json b/test/fixtures/esbuild.ts/0/package.json
new file mode 100644
index 0000000..b32c446
--- /dev/null
+++ b/test/fixtures/esbuild.ts/0/package.json
@@ -0,0 +1,6 @@
+{
+  "dependencies": {
+    "esbuild": "^0.14.29",
+    "esbuild-register": "^3.3.2"
+  }
+}
diff --git a/test/fixtures/esbuild.ts/0/test.esbuild.ts b/test/fixtures/esbuild.ts/0/test.esbuild.ts
new file mode 100644
index 0000000..3a027f2
--- /dev/null
+++ b/test/fixtures/esbuild.ts/0/test.esbuild.ts
@@ -0,0 +1,14 @@
+class Foo {
+  #x: number = 1
+  #y: number = 2
+}
+
+export default {
+  data: {
+    trueKey: true as boolean,
+    falseKey: false as boolean,
+    subKey: {
+      subProp: 1,
+    },
+  },
+} as const;
diff --git a/test/fixtures/esbuild.tsx/0/package.json b/test/fixtures/esbuild.tsx/0/package.json
new file mode 100644
index 0000000..b32c446
--- /dev/null
+++ b/test/fixtures/esbuild.tsx/0/package.json
@@ -0,0 +1,6 @@
+{
+  "dependencies": {
+    "esbuild": "^0.14.29",
+    "esbuild-register": "^3.3.2"
+  }
+}
diff --git a/test/fixtures/esbuild.tsx/0/test.esbuild.tsx b/test/fixtures/esbuild.tsx/0/test.esbuild.tsx
new file mode 100644
index 0000000..4215dfc
--- /dev/null
+++ b/test/fixtures/esbuild.tsx/0/test.esbuild.tsx
@@ -0,0 +1,28 @@
+const React = {
+  createElement(Component) {
+    return Component()
+  }
+}
+
+class Foo {
+  #x: number = 1
+  #y: number = 2
+}
+
+function Bar() {
+  const foo = new Foo();
+
+  return foo;
+}
+
+const a = <Bar />
+
+export default {
+  data: {
+    trueKey: true as boolean,
+    falseKey: false as boolean,
+    subKey: {
+      subProp: 1,
+    },
+  },
+} as const;
diff --git a/test/index.js b/test/index.js
index a878b6f..b0ccad2 100644
--- a/test/index.js
+++ b/test/index.js
@@ -156,6 +156,10 @@ describe('interpret.extensions', function() {
         case '.ts':
         case '.tsx':
         case '.esm.js':
+        case '.esbuild.js':
+        case '.esbuild.jsx':
+        case '.esbuild.ts':
+        case '.esbuild.tsx':
           expected = {
             default: {
               data: {