diff --git a/common/reactive/src/main/java/io/helidon/common/reactive/Awaitable.java b/common/reactive/src/main/java/io/helidon/common/reactive/Awaitable.java
index 5b2a0e606ea..3a3c621b740 100644
--- a/common/reactive/src/main/java/io/helidon/common/reactive/Awaitable.java
+++ b/common/reactive/src/main/java/io/helidon/common/reactive/Awaitable.java
@@ -1,5 +1,5 @@
 /*
- * Copyright (c) 2020, 2021 Oracle and/or its affiliates.
+ * Copyright (c) 2020, 2022 Oracle and/or its affiliates.
  *
  * Licensed under the Apache License, Version 2.0 (the "License");
  * you may not use this file except in compliance with the License.
@@ -63,7 +63,9 @@ default T await() {
      * @throws java.util.concurrent.CancellationException if this future was cancelled
      * @throws java.util.concurrent.CompletionException   if this future completed exceptionally,
      *                                                    was interrupted while waiting or the wait timed out
+     * @deprecated use {@link #await(Duration)} instead
      */
+    @Deprecated(since = "4.0.0")
     default T await(long timeout, TimeUnit unit) {
         try {
             return this.toCompletableFuture().get(timeout, unit);
diff --git a/common/reactive/src/main/java/io/helidon/common/reactive/IoMulti.java b/common/reactive/src/main/java/io/helidon/common/reactive/IoMulti.java
index 11c1bdf0cd3..67f9502f083 100644
--- a/common/reactive/src/main/java/io/helidon/common/reactive/IoMulti.java
+++ b/common/reactive/src/main/java/io/helidon/common/reactive/IoMulti.java
@@ -1,5 +1,5 @@
 /*
- * Copyright (c) 2020, 2021 Oracle and/or its affiliates.
+ * Copyright (c) 2020, 2022 Oracle and/or its affiliates.
  *
  * Licensed under the Apache License, Version 2.0 (the "License");
  * you may not use this file except in compliance with the License.
@@ -446,12 +446,26 @@ private OutputStreamMultiBuilder() {
          * @param timeout the maximum time to block
          * @param unit    the time unit of the timeout argument
          * @return this builder
+         * @deprecated use {@link #timeout(Duration)} instead
          */
+        @Deprecated(since = "4.0.0")
         public OutputStreamMultiBuilder timeout(long timeout, TimeUnit unit) {
             this.timeout = Duration.of(timeout, unit.toChronoUnit());
             return this;
         }
 
+        /**
+         * Set max timeout for which is allowed to block write methods,
+         * in case there is no demand from downstream.
+         *
+         * @param timeout the maximum time to block
+         * @return this builder
+         */
+        public OutputStreamMultiBuilder timeout(Duration timeout) {
+            this.timeout = timeout;
+            return this;
+        }
+
         /**
          * Callback executed when request signal from downstream arrive.
          * <ul>
diff --git a/config/config/src/main/java/io/helidon/config/FileSystemWatcher.java b/config/config/src/main/java/io/helidon/config/FileSystemWatcher.java
index b784b106117..b91c8986eaa 100644
--- a/config/config/src/main/java/io/helidon/config/FileSystemWatcher.java
+++ b/config/config/src/main/java/io/helidon/config/FileSystemWatcher.java
@@ -24,6 +24,7 @@
 import java.nio.file.WatchEvent;
 import java.nio.file.WatchKey;
 import java.nio.file.WatchService;
+import java.time.Duration;
 import java.util.Arrays;
 import java.util.Collections;
 import java.util.LinkedList;
@@ -413,8 +414,10 @@ public Builder executor(ScheduledExecutorService executor) {
          * @param initialDelay initial delay before regular scheduling starts
          * @param delay delay between schedules
          * @param timeUnit time unit of the delays
-         * @return updated builer instance
+         * @return updated builder instance
+         * @deprecated use {@link #initialDelay(Duration)} and {@link #delay(Duration)} instead
          */
+        @Deprecated(since = "4.0.0")
         public Builder schedule(long initialDelay, long delay, TimeUnit timeUnit) {
             this.initialDelay = initialDelay;
             this.delay = delay;
@@ -422,6 +425,30 @@ public Builder schedule(long initialDelay, long delay, TimeUnit timeUnit) {
             return this;
         }
 
+        /**
+         * Configure an initial delay before regular scheduling starts.
+         *
+         * @param initialDelay initial delay
+         * @return updated builder instance
+         */
+        public Builder initialDelay(Duration initialDelay) {
+            this.initialDelay = initialDelay.toMillis();
+            this.timeUnit = TimeUnit.MILLISECONDS;
+            return this;
+        }
+
+        /**
+         * Configure a delay between schedules.
+         *
+         * @param delay delay between schedules
+         * @return updated builder instance
+         */
+        public Builder delay(Duration delay) {
+            this.delay = delay.toMillis();
+            this.timeUnit = TimeUnit.MILLISECONDS;
+            return this;
+        }
+
         /**
          * Add a modifier of the watch service.
          * Currently only implementation specific modifier are available, such as
diff --git a/integrations/microstream/health/src/main/java/io/helidon/integrations/microstream/health/MicrostreamHealthCheck.java b/integrations/microstream/health/src/main/java/io/helidon/integrations/microstream/health/MicrostreamHealthCheck.java
index 79c4c2e18bb..e94b0263db7 100644
--- a/integrations/microstream/health/src/main/java/io/helidon/integrations/microstream/health/MicrostreamHealthCheck.java
+++ b/integrations/microstream/health/src/main/java/io/helidon/integrations/microstream/health/MicrostreamHealthCheck.java
@@ -1,5 +1,5 @@
 /*
- * Copyright (c) 2021 Oracle and/or its affiliates.
+ * Copyright (c) 2021, 2022 Oracle and/or its affiliates.
  *
  * Licensed under the Apache License, Version 2.0 (the "License");
  * you may not use this file except in compliance with the License.
@@ -16,6 +16,7 @@
 
 package io.helidon.integrations.microstream.health;
 
+import java.time.Duration;
 import java.util.concurrent.CompletableFuture;
 import java.util.concurrent.TimeUnit;
 
@@ -129,11 +130,26 @@ public Builder name(String name) {
          * @param duration the maximum time to wait for statement execution response
          * @param timeUnit the time unit of the timeout argument
          * @return updated builder instance
+         * @deprecated use {@link #timeout(Duration)} instead
          */
+        @Deprecated(since = "4.0.0")
         public Builder timeout(long duration, TimeUnit timeUnit) {
             this.timeoutDuration = duration;
             this.timeoutUnit = timeUnit;
             return this;
         }
+
+        /**
+         * Set custom timeout to wait for statement execution response. Default value is
+         * 10 seconds.
+         *
+         * @param duration the maximum time to wait for statement execution response
+         * @return updated builder instance
+         */
+        public Builder timeout(Duration duration) {
+            this.timeoutDuration = duration.toNanos();
+            this.timeoutUnit = TimeUnit.NANOSECONDS;
+            return this;
+        }
     }
 }
diff --git a/lra/coordinator/client/narayana-client/src/main/java/io/helidon/lra/coordinator/client/narayana/NarayanaClient.java b/lra/coordinator/client/narayana-client/src/main/java/io/helidon/lra/coordinator/client/narayana/NarayanaClient.java
index 178a78126e0..7dfc4872277 100644
--- a/lra/coordinator/client/narayana-client/src/main/java/io/helidon/lra/coordinator/client/narayana/NarayanaClient.java
+++ b/lra/coordinator/client/narayana-client/src/main/java/io/helidon/lra/coordinator/client/narayana/NarayanaClient.java
@@ -20,7 +20,6 @@
 import java.util.List;
 import java.util.Map;
 import java.util.Optional;
-import java.util.concurrent.TimeUnit;
 import java.util.function.Function;
 import java.util.function.Supplier;
 import java.util.logging.Level;
@@ -61,17 +60,15 @@ public class NarayanaClient implements CoordinatorClient {
     private static final Pattern LRA_ID_PATTERN = Pattern.compile("(.*)/([^/?]+).*");
 
     private Supplier<URI> coordinatorUriSupplier;
-    private Long coordinatorTimeout;
-    private TimeUnit coordinatorTimeoutUnit;
+    private Duration coordinatorTimeout;
     private Retry retry;
 
     @Override
-    public void init(Supplier<URI> coordinatorUriSupplier, long timeout, TimeUnit timeoutUnit) {
+    public void init(Supplier<URI> coordinatorUriSupplier, Duration timeout) {
         this.coordinatorUriSupplier = coordinatorUriSupplier;
         this.coordinatorTimeout = timeout;
-        this.coordinatorTimeoutUnit = timeoutUnit;
         this.retry = Retry.builder()
-                .overallTimeout(Duration.ofMillis(timeoutUnit.toMillis(timeout)))
+                .overallTimeout(timeout)
                 .retryPolicy(Retry.JitterRetryPolicy.builder()
                         .calls(RETRY_ATTEMPTS)
                         .build())
@@ -289,8 +286,8 @@ private WebClient prepareWebClient(URI uri) {
                 .baseUri(uri)
                 // Workaround for #3242
                 .keepAlive(false)
-                .connectTimeout(coordinatorTimeout, coordinatorTimeoutUnit)
-                .readTimeout(coordinatorTimeout, coordinatorTimeoutUnit)
+                .connectTimeout(coordinatorTimeout)
+                .readTimeout(coordinatorTimeout)
                 .addReader(new LraStatusReader())
                 .build();
     }
diff --git a/lra/coordinator/client/spi/src/main/java/io/helidon/lra/coordinator/client/CoordinatorClient.java b/lra/coordinator/client/spi/src/main/java/io/helidon/lra/coordinator/client/CoordinatorClient.java
index 01ab239c17f..1a1e135f514 100644
--- a/lra/coordinator/client/spi/src/main/java/io/helidon/lra/coordinator/client/CoordinatorClient.java
+++ b/lra/coordinator/client/spi/src/main/java/io/helidon/lra/coordinator/client/CoordinatorClient.java
@@ -17,6 +17,7 @@
 package io.helidon.lra.coordinator.client;
 
 import java.net.URI;
+import java.time.Duration;
 import java.util.Optional;
 import java.util.concurrent.TimeUnit;
 import java.util.function.Supplier;
@@ -59,8 +60,20 @@ public interface CoordinatorClient {
      * @param coordinatorUriSupplier url of the coordinator
      * @param timeout                general timeout for coordinator calls
      * @param timeoutUnit            timeout unit for coordinator calls
+     * @deprecated use {@link #init(Supplier, Duration)} instead
      */
-    void init(Supplier<URI> coordinatorUriSupplier, long timeout, TimeUnit timeoutUnit);
+    @Deprecated(forRemoval = true, since = "4.0.0")
+    default void init(Supplier<URI> coordinatorUriSupplier, long timeout, TimeUnit timeoutUnit){
+        init(coordinatorUriSupplier, Duration.ofMillis(timeoutUnit.toMillis(timeout)));
+    }
+
+    /**
+     * Initialization of the properties provided by LRA client.
+     *
+     * @param coordinatorUriSupplier url of the coordinator
+     * @param timeout                general timeout for coordinator calls
+     */
+    void init(Supplier<URI> coordinatorUriSupplier, Duration timeout);
 
     /**
      * Ask coordinator to start new LRA and return its id.
diff --git a/reactive/dbclient/health/src/main/java/io/helidon/reactive/dbclient/health/DbClientHealthCheck.java b/reactive/dbclient/health/src/main/java/io/helidon/reactive/dbclient/health/DbClientHealthCheck.java
index ad03300b5ba..9f49db50ab0 100644
--- a/reactive/dbclient/health/src/main/java/io/helidon/reactive/dbclient/health/DbClientHealthCheck.java
+++ b/reactive/dbclient/health/src/main/java/io/helidon/reactive/dbclient/health/DbClientHealthCheck.java
@@ -483,13 +483,28 @@ public Builder statement(final String statement) {
          * @param duration the maximum time to wait for statement execution response
          * @param timeUnit    the time unit of the timeout argument
          * @return updated builder instance
+         * @deprecated use {@link #timeout(Duration)} instead
          */
+        @Deprecated(since = "4.0.0")
         public Builder timeout(final long duration, final TimeUnit timeUnit) {
             this.timeoutDuration = duration;
             this.timeoutUnit = timeUnit;
             return this;
         }
 
+        /**
+         * Set custom timeout to wait for statement execution response.
+         * Default value is {@code 10} seconds.
+         *
+         * @param timeout the maximum time to wait for statement execution response
+         * @return updated builder instance
+         */
+        public Builder timeout(final Duration timeout) {
+            this.timeoutDuration = timeout.toNanos();
+            this.timeoutUnit = TimeUnit.NANOSECONDS;
+            return this;
+        }
+
         // Getters for local usage and jUnit tests
 
         String name() {
diff --git a/reactive/health/src/main/java/io/helidon/reactive/health/HealthSupport.java b/reactive/health/src/main/java/io/helidon/reactive/health/HealthSupport.java
index a5152c29e0b..45a838cfb31 100644
--- a/reactive/health/src/main/java/io/helidon/reactive/health/HealthSupport.java
+++ b/reactive/health/src/main/java/io/helidon/reactive/health/HealthSupport.java
@@ -113,7 +113,7 @@ private HealthSupport(Builder builder) {
         }
 
         // Lazy values to prevent early init of maybe-not-yet-configured FT thread pools
-        this.timeout = LazyValue.create(() -> Timeout.create(Duration.ofMillis(builder.timeoutMillis)));
+        this.timeout = LazyValue.create(() -> Timeout.create(builder.timeout));
         this.async = LazyValue.create(Async::create);
     }
 
@@ -369,7 +369,7 @@ public static final class Builder extends HelidonRestServiceSupport.Builder<Buil
         private final Set<String> excludedHealthChecks = new HashSet<>();
         private boolean details = true;
         private boolean enabled = true;
-        private long timeoutMillis = DEFAULT_TIMEOUT_MILLIS;
+        private Duration timeout = Duration.ofMillis(DEFAULT_TIMEOUT_MILLIS);
 
         private Builder() {
             super(DEFAULT_WEB_CONTEXT);
@@ -454,7 +454,7 @@ public Builder config(Config config) {
         }
 
         private void timeoutMillis(long aLong) {
-            this.timeoutMillis = aLong;
+            this.timeout = Duration.ofMillis(aLong);
         }
 
         /**
@@ -463,16 +463,29 @@ private void timeoutMillis(long aLong) {
          * @param timeout timeout value
          * @param unit timeout time unit
          * @return updated builder instance
+         * @deprecated use {@link #timeout(Duration)} instead
          */
         @ConfiguredOption(key = TIMEOUT_CONFIG_KEY,
                           description = "health endpoint timeout (ms)",
                           type = Long.class,
                           value = "10000")
+        @Deprecated(since = "4.0.0")
         public Builder timeout(long timeout, TimeUnit unit) {
             timeoutMillis(unit.toMillis(timeout));
             return this;
         }
 
+        /**
+         * Configure overall timeout of health check call.
+         *
+         * @param timeout timeout value
+         * @return updated builder instance
+         */
+        public Builder timeout(Duration timeout) {
+            this.timeout = timeout;
+            return this;
+        }
+
         /**
          * A class may be excluded from invoking health checks on it.
          * This allows configurable approach to disabling broken health-checks.
diff --git a/reactive/webclient/webclient/src/main/java/io/helidon/reactive/webclient/WebClient.java b/reactive/webclient/webclient/src/main/java/io/helidon/reactive/webclient/WebClient.java
index ef640a2519c..616d8e79329 100644
--- a/reactive/webclient/webclient/src/main/java/io/helidon/reactive/webclient/WebClient.java
+++ b/reactive/webclient/webclient/src/main/java/io/helidon/reactive/webclient/WebClient.java
@@ -269,7 +269,9 @@ public Builder config(Config config) {
          * @param amount amount of time
          * @param unit   time unit
          * @return updated builder instance
+         * @deprecated use {@link #connectTimeout(Duration)} instead
          */
+        @Deprecated(since = "4.0.0")
         public Builder connectTimeout(long amount, TimeUnit unit) {
             return connectTimeout(Duration.of(amount, unit.toChronoUnit()));
         }
@@ -291,7 +293,9 @@ public Builder connectTimeout(Duration timeout) {
          * @param amount amount of time
          * @param unit   time unit
          * @return updated builder instance
+         * @deprecated use {@link #readTimeout(Duration)} instead
          */
+        @Deprecated(since = "4.0.0")
         public Builder readTimeout(long amount, TimeUnit unit) {
             return readTimeout(Duration.of(amount, unit.toChronoUnit()));
         }
diff --git a/reactive/webclient/webclient/src/main/java/io/helidon/reactive/webclient/WebClientRequestBuilder.java b/reactive/webclient/webclient/src/main/java/io/helidon/reactive/webclient/WebClientRequestBuilder.java
index c6079343211..a09bf76636a 100644
--- a/reactive/webclient/webclient/src/main/java/io/helidon/reactive/webclient/WebClientRequestBuilder.java
+++ b/reactive/webclient/webclient/src/main/java/io/helidon/reactive/webclient/WebClientRequestBuilder.java
@@ -17,6 +17,7 @@
 
 import java.net.URI;
 import java.net.URL;
+import java.time.Duration;
 import java.util.List;
 import java.util.Map;
 import java.util.concurrent.CompletionStage;
@@ -270,18 +271,38 @@ default WebClientRequestBuilder addHeaders(Headers parameters){
      * @param amount amount of time
      * @param unit   time unit
      * @return updated builder instance
+     * @deprecated use {@link #connectTimeout(Duration)} instead
      */
+    @Deprecated(since = "4.0.0")
     WebClientRequestBuilder connectTimeout(long amount, TimeUnit unit);
 
+    /**
+     * Sets new connection timeout for this request.
+     *
+     * @param connectionTimeout amount of time
+     * @return updated builder instance
+     */
+    WebClientRequestBuilder connectTimeout(Duration connectionTimeout);
+
     /**
      * Sets new read timeout for this request.
      *
      * @param amount amount of time
      * @param unit   time unit
      * @return updated builder instance
+     * @deprecated use {@link #readTimeout(Duration)} instead
      */
+    @Deprecated(since = "4.0.0")
     WebClientRequestBuilder readTimeout(long amount, TimeUnit unit);
 
+    /**
+     * Sets new read timeout for this request.
+     *
+     * @param readTimeout amount of time
+     * @return updated builder instance
+     */
+    WebClientRequestBuilder readTimeout(Duration readTimeout);
+
     /**
      * Fragment of the request.
      *
diff --git a/reactive/webclient/webclient/src/main/java/io/helidon/reactive/webclient/WebClientRequestBuilderImpl.java b/reactive/webclient/webclient/src/main/java/io/helidon/reactive/webclient/WebClientRequestBuilderImpl.java
index 2e7284597b1..7bac0002b22 100644
--- a/reactive/webclient/webclient/src/main/java/io/helidon/reactive/webclient/WebClientRequestBuilderImpl.java
+++ b/reactive/webclient/webclient/src/main/java/io/helidon/reactive/webclient/WebClientRequestBuilderImpl.java
@@ -342,12 +342,24 @@ public WebClientRequestBuilder connectTimeout(long amount, TimeUnit unit) {
         return this;
     }
 
+    @Override
+    public WebClientRequestBuilder connectTimeout(Duration connectTimeout) {
+        this.connectTimeout = connectTimeout;
+        return this;
+    }
+
     @Override
     public WebClientRequestBuilder readTimeout(long amount, TimeUnit unit) {
         this.readTimeout = Duration.of(amount, unit.toChronoUnit());
         return this;
     }
 
+    @Override
+    public WebClientRequestBuilder readTimeout(Duration readTimeout) {
+        this.readTimeout = readTimeout;
+        return this;
+    }
+
     @Override
     public WebClientRequestBuilder fragment(String fragment) {
         this.fragment = fragment;