diff --git a/.github/workflows/update-dependencies.yml b/.github/workflows/update-dependencies.yml
index 7814fe46..72071fa4 100644
--- a/.github/workflows/update-dependencies.yml
+++ b/.github/workflows/update-dependencies.yml
@@ -8,6 +8,9 @@ on:
   schedule:
     - cron: '0 18 * * 0'  # "At 18:00 on Sunday."
 
+env:
+  FORCE_COLOR: '1'
+
 jobs:
   update-dependencies:
     name: Update dependencies
@@ -30,13 +33,13 @@ jobs:
         app_id: ${{ secrets.MANYLINUX_BOT_APP_ID }}
         private_key: ${{ secrets.MANYLINUX_BOT_APP_PRIVATE_KEY }}
     - name: "Run update native dependencies"
-      run: nox --force-color --error-on-missing-interpreters -s update_native_dependencies
+      run: nox -s update_native_dependencies
       env:
         GITHUB_API_TOKEN: ${{ steps.generate-token.outputs.token || github.token }}
     - name: "Run update downloaded interpreters"
-      run: nox --force-color --error-on-missing-interpreters -s update_interpreters_download
+      run: nox -s update_interpreters_download
     - name: "Run update python dependencies"
-      run: nox --force-color --error-on-missing-interpreters -s update_python_dependencies
+      run: nox -s update_python_dependencies
     - name: Create Pull Request
       if: github.ref == 'refs/heads/main' && github.repository == 'pypa/manylinux'
       uses: peter-evans/create-pull-request@v5
diff --git a/README.rst b/README.rst
index 84e81456..1b98df98 100644
--- a/README.rst
+++ b/README.rst
@@ -210,7 +210,18 @@ All images currently contain:
 
 - Development packages for all the libraries that PEP 571/599 list. One should not assume the presence of any other development package.
 
-- The `auditwheel <https://pypi.python.org/pypi/auditwheel>`_ tool
+- The following development tools, installed via `pipx <https://pypi.org/p/pipx>`_ (which is also available):
+   - `auditwheel <https://pypi.org/p/auditwheel>`_
+   - `cmake <https://pypi.org/p/cmake>`_
+   - `patchelf <https://pypi.org/p/patchelf>`_
+   - `swig <https://pypi.org/p/swig>`_
+   - `uv <https://pypi.org/p/uv>`_ (not available on ``musllinux s390x`` and ``muslllinux powerpc64le`` yet due to Rust limitations)
+
+- All Python interpreters have the following packages pre-installed:
+  - `pip <https://pypi.org/p/pip>`_
+  - `build <https://pypi.org/p/build>`_
+  - `packaging <https://pypi.org/p/packaging>`_
+  - Before Python 3.12, `setuptools <https://pypi.org/p/setuptools>`_ and `wheel <https://pypi.org/p/wheel>`_ are also available. (Currently 3.12 too, but will be removed after 3.13 is released.)
 
 - The manylinux-interpreters tool which allows to list all available interpreters & install ones missing from the image
 
diff --git a/docker/build_scripts/finalize.sh b/docker/build_scripts/finalize.sh
index df050989..08b7a592 100755
--- a/docker/build_scripts/finalize.sh
+++ b/docker/build_scripts/finalize.sh
@@ -79,7 +79,9 @@ pipx uninstall pip
 # install other tools with pipx
 for TOOL_PATH in $(find ${MY_DIR}/requirements-tools -type f); do
 	TOOL=$(basename ${TOOL_PATH})
-	pipx install --pip-args="--require-hashes -r ${TOOL_PATH} --only-binary" ${TOOL}
+	if [[ "$TOOL" != "uv" || "$AUDITWHEEL_POLICY" != musllinux* || ("$AUDITWHEEL_ARCH" != "s390x" && "$AUDITWHEEL_ARCH" != "powerpc64le") ]]; then
+		pipx install --pip-args="--require-hashes -r ${TOOL_PATH} --only-binary" ${TOOL}
+	fi
 done
 
 # We do not need the precompiled .pyc and .pyo files.
diff --git a/docker/build_scripts/requirements-tools/uv b/docker/build_scripts/requirements-tools/uv
new file mode 100644
index 00000000..0c691339
--- /dev/null
+++ b/docker/build_scripts/requirements-tools/uv
@@ -0,0 +1,20 @@
+# This file was autogenerated by uv via the following command:
+#    nox -s update_python_dependencies
+uv==0.1.43 \
+    --hash=sha256:04c5b815d5d679b962249c1e03606ab78163ba7eea0ba2b47bcfc9b2f19abfba \
+    --hash=sha256:177044b9002da3c278002d51fad8e6e730a6ed39a2b0cde4f4a66326698811f9 \
+    --hash=sha256:1d5fc94e8c1308213ce0909f69f4683bd1daaad08c451cadd4fe1a656fd7e119 \
+    --hash=sha256:326232a9750945192018f0b74ad7450cec2309a00dbee7291cf5cabc1665980e \
+    --hash=sha256:4be5a9fe315340f10900df29029b29fa75eb0722e3052a937991c35aa3af0869 \
+    --hash=sha256:537439f955e361e0d2113710ae5339fd7cb0cefb7274f7ed33351248ab22c254 \
+    --hash=sha256:58446aadbae300c92300ba6686c5f802a647478d894efc5725315a947d62345e \
+    --hash=sha256:99f9ee893a597374630df23a873e2888ad333e1d31bdca103914c2236ce77ed7 \
+    --hash=sha256:a4e4f86afbf5949da8a1eb376327866158bcfda3a92d25e74b0ce9988d7bf477 \
+    --hash=sha256:a5f16230631d4fd2d0b98a89759b256bdf647c3e7641b39e9632652137b3f901 \
+    --hash=sha256:a8c0447cdd2c54b58c33ad06305812e918c0bc5695370a60c12cc0045dcc5b32 \
+    --hash=sha256:b5365c163cdbc50bc97ebe2607357241cecb2d6c8e05916b4a495a0089a9e311 \
+    --hash=sha256:bd06f50cbbc1536d679aa1366011af04c7b613e84396e917bb0014a4b5de8e47 \
+    --hash=sha256:d2d3f592543aa9dd3bf59c5cfe2479d05fa07690449ddf94e225cd6d1567c743 \
+    --hash=sha256:e198f64dfc85d55cf8861a4a57aa6fbafe8f969261f6bceb400e4ac1ca595428 \
+    --hash=sha256:f495da8017453d5b185f6d2b3d57c6a60e063136aaa6e8bf92164bb3573cab45 \
+    --hash=sha256:f54666b392ca0db4d4b6a23aceb1fba1e7329dc1e2882a252afe407034de316c
diff --git a/noxfile.py b/noxfile.py
index b0e4c0be..220eb95c 100644
--- a/noxfile.py
+++ b/noxfile.py
@@ -4,9 +4,13 @@
 
 import nox
 
+nox.needs_version = ">=2024.4.15"
+nox.options.default_venv_backend = "uv|virtualenv"
+
 
 @nox.session
 def update_python_dependencies(session):
+    "Update the base and per-python dependencies lockfiles"
     if getattr(session.virtualenv, "venv_backend", "") != "uv":
         session.install("uv>=0.1.23")
 
@@ -60,11 +64,15 @@ def update_python_dependencies(session):
 
 @nox.session(python="3.11", reuse_venv=True)
 def update_native_dependencies(session):
-    session.install("lastversion>=3.5.0", "packaging", "requests")
+    "Update the native dependencies"
+    deps = nox.project.load_toml(script)["dependencies"]
+    session.install(*deps)
     session.run("python", "tools/update_native_dependencies.py", *session.posargs)
 
 
 @nox.session(python="3.11", reuse_venv=True)
 def update_interpreters_download(session):
-    session.install("packaging", "requests")
+    "Update all the Python interpreters"
+    deps = nox.project.load_toml(script)["dependencies"]
+    session.install(*deps)
     session.run("python", "tools/update_interpreters_download.py", *session.posargs)
diff --git a/requirements-tools.in b/requirements-tools.in
index 5a11bef3..cb04eb9c 100644
--- a/requirements-tools.in
+++ b/requirements-tools.in
@@ -2,3 +2,4 @@ auditwheel
 cmake
 patchelf
 swig
+uv
diff --git a/tools/update_interpreters_download.py b/tools/update_interpreters_download.py
index 094653e4..5e04662d 100644
--- a/tools/update_interpreters_download.py
+++ b/tools/update_interpreters_download.py
@@ -1,3 +1,9 @@
+#!/usr/bin/env python
+
+# /// script
+# dependencies = ["packaging", "requests"]
+# ///
+
 from __future__ import annotations
 
 import argparse
diff --git a/tools/update_native_dependencies.py b/tools/update_native_dependencies.py
index 74afc8e6..d342a269 100644
--- a/tools/update_native_dependencies.py
+++ b/tools/update_native_dependencies.py
@@ -1,3 +1,9 @@
+#!/usr/bin/env python
+
+# /// script
+# dependencies = ["lastversion>=3.5.0", "packaging", "requests"]
+# ///
+
 import argparse
 import hashlib
 import re