diff --git a/sqlx-sqlite/src/options/mod.rs b/sqlx-sqlite/src/options/mod.rs
index b0093f3d45..d3ed8b9f36 100644
--- a/sqlx-sqlite/src/options/mod.rs
+++ b/sqlx-sqlite/src/options/mod.rs
@@ -210,6 +210,10 @@ impl SqliteConnectOptions {
     }
 
     /// Sets the name of the database file.
+    ///
+    /// This is a low-level API, and SQLx will apply no special treatment for `":memory:"` as an
+    /// in-memory database using this method. Using [SqliteConnectOptions::from_str] may be
+    /// preferred for simple use cases.
     pub fn filename(mut self, filename: impl AsRef<Path>) -> Self {
         self.filename = Cow::Owned(filename.as_ref().to_owned());
         self
@@ -228,6 +232,14 @@ impl SqliteConnectOptions {
         self.pragma("foreign_keys", if on { "ON" } else { "OFF" })
     }
 
+    /// Set the [`SQLITE_OPEN_MEMORY` flag](https://sqlite.org/c3ref/open.html).
+    ///
+    /// By default, this is disabled.
+    pub fn in_memory(mut self, in_memory: bool) -> Self {
+        self.in_memory = in_memory;
+        self
+    }
+
     /// Set the [`SQLITE_OPEN_SHAREDCACHE` flag](https://sqlite.org/sharedcache.html).
     ///
     /// By default, this is disabled.