diff --git a/pkg/neg/types/types.go b/pkg/neg/types/types.go
index d9f353dcf4..0c7144adce 100644
--- a/pkg/neg/types/types.go
+++ b/pkg/neg/types/types.go
@@ -340,6 +340,10 @@ func EndpointsDataFromEndpoints(ep *apiv1.Endpoints) []EndpointsData {
 func EndpointsDataFromEndpointSlices(slices []*discovery.EndpointSlice) []EndpointsData {
 	result := make([]EndpointsData, 0, len(slices))
 	for _, slice := range slices {
+		if slice.AddressType != discovery.AddressTypeIPv4 {
+			// Neg Controller can only attach IPv4 endpoints
+			continue
+		}
 		ports := make([]PortData, 0)
 		addresses := make([]AddressData, 0)
 		for _, port := range slice.Ports {
diff --git a/pkg/neg/types/types_test.go b/pkg/neg/types/types_test.go
index 5ce1b0c5d5..66b32255c6 100644
--- a/pkg/neg/types/types_test.go
+++ b/pkg/neg/types/types_test.go
@@ -665,6 +665,47 @@ func TestEndpointsDataFromEndpointSlices(t *testing.T) {
 				},
 			},
 		},
+		{
+			ObjectMeta: metav1.ObjectMeta{
+				Name:      testServiceName + "-2",
+				Namespace: testServiceNamespace,
+			},
+			AddressType: discovery.AddressTypeIPv6,
+			Endpoints: []discovery.Endpoint{
+				{
+					Addresses: []string{"aa:aa:aa:aa:aa:aa"},
+					NodeName:  &instance2,
+					TargetRef: &v1.ObjectReference{
+						Namespace: testServiceNamespace,
+						Name:      "pod7",
+					},
+				},
+				{
+					Addresses: []string{"aa:aa:aa:aa:aa:ab"},
+					NodeName:  &instance4,
+					TargetRef: &v1.ObjectReference{
+						Namespace: testServiceNamespace,
+						Name:      "pod8",
+					},
+				},
+				{
+					Addresses: []string{"aa:aa:aa:aa:aa:ac"},
+					NodeName:  &instance4,
+					TargetRef: &v1.ObjectReference{
+						Namespace: testServiceNamespace,
+						Name:      "pod9",
+					},
+					Conditions: discovery.EndpointConditions{Ready: &notReady},
+				},
+			},
+			Ports: []discovery.EndpointPort{
+				{
+					Name:     &testNamedPort,
+					Port:     &port81,
+					Protocol: &protocolTCP,
+				},
+			},
+		},
 	}
 
 	endpointsData := EndpointsDataFromEndpointSlices(endpointSlices)
@@ -672,7 +713,11 @@ func TestEndpointsDataFromEndpointSlices(t *testing.T) {
 	if len(endpointsData) != 2 {
 		t.Errorf("Expected the same number of endpoints subsets and endpoints data, got %d endpoints data for 2 subsets", len(endpointsData))
 	}
+	// This test expects that all the valid EPS are at the beginning
 	for i, slice := range endpointSlices {
+		if slice.AddressType != discovery.AddressTypeIPv4 {
+			continue
+		}
 		for j, port := range slice.Ports {
 			ValidatePortData(endpointsData[i].Ports[j], *port.Port, *port.Name, t)
 		}