diff --git a/src/tests/issues.targets b/src/tests/issues.targets
index 91b540fe4f18f..e35f4dc231dee 100644
--- a/src/tests/issues.targets
+++ b/src/tests/issues.targets
@@ -117,6 +117,9 @@
         <ExcludeList Include="$(XunitTestBinBase)/JIT/Regression/JitBlue/DevDiv_255294/DevDiv_255294/*">
             <Issue>https://github.com/dotnet/runtime/issues/44341</Issue>
         </ExcludeList>
+        <ExcludeList Include="$(XunitTestBinBase)/JIT/Regression/JitBlue/GitHub_13822/GitHub_13822/*">
+            <Issue>https://github.com/dotnet/runtime/issues/53781</Issue>
+        </ExcludeList>
         <ExcludeList Include="$(XunitTestBinBase)/Interop/COM/NativeClients/Dispatch/*">
             <Issue>https://github.com/dotnet/runtime/issues/44186</Issue>
         </ExcludeList>