diff --git a/Lib/test/test_signal.py b/Lib/test/test_signal.py
index 0f3343b10e4a07..04f43ceb489c5c 100644
--- a/Lib/test/test_signal.py
+++ b/Lib/test/test_signal.py
@@ -1326,6 +1326,7 @@ def handler(signum, frame):
         # Python handler
         self.assertEqual(len(sigs), N, "Some signals were lost")
 
+    @unittest.skipIf(sys.platform == "darwin", "crashes due to system bug (FB13453490)")
     @unittest.skipUnless(hasattr(signal, "SIGUSR1"),
                          "test needs SIGUSR1")
     @threading_helper.requires_working_threading()
diff --git a/Misc/NEWS.d/next/macOS/2023-12-07-15-53-16.gh-issue-110017.UMYzMR.rst b/Misc/NEWS.d/next/macOS/2023-12-07-15-53-16.gh-issue-110017.UMYzMR.rst
new file mode 100644
index 00000000000000..eab1746f1ae3f7
--- /dev/null
+++ b/Misc/NEWS.d/next/macOS/2023-12-07-15-53-16.gh-issue-110017.UMYzMR.rst
@@ -0,0 +1,2 @@
+Disable a signal handling stress test on macOS due to a bug in macOS
+(FB13453490).