diff --git a/lib/internal/http2/core.js b/lib/internal/http2/core.js
index 0b9be932af3479..27fe4f26e31757 100644
--- a/lib/internal/http2/core.js
+++ b/lib/internal/http2/core.js
@@ -1464,6 +1464,14 @@ function afterShutdown() {
 }
 
 function finishSendTrailers(stream, headersList) {
+  // The stream might be destroyed and in that case
+  // there is nothing to do.
+  // This can happen because finishSendTrailers is
+  // scheduled via setImmediate.
+  if (stream.destroyed) {
+    return;
+  }
+
   stream[kState].flags &= ~STREAM_FLAGS_HAS_TRAILERS;
 
   const ret = stream[kHandle].trailers(headersList);
diff --git a/test/parallel/test-http2-compat-socket-destroy-delayed.js b/test/parallel/test-http2-compat-socket-destroy-delayed.js
new file mode 100644
index 00000000000000..62405047d8266e
--- /dev/null
+++ b/test/parallel/test-http2-compat-socket-destroy-delayed.js
@@ -0,0 +1,42 @@
+'use strict';
+
+const common = require('../common');
+const { mustCall } = common;
+
+if (!common.hasCrypto)
+  common.skip('missing crypto');
+
+const http2 = require('http2');
+const assert = require('assert');
+
+const {
+  HTTP2_HEADER_PATH,
+  HTTP2_HEADER_METHOD,
+} = http2.constants;
+
+// This tests verifies that calling `req.socket.destroy()` via
+// setImmediate does not crash.
+// Fixes https://github.com/nodejs/node/issues/22855.
+
+const app = http2.createServer(mustCall((req, res) => {
+  res.end('hello');
+  setImmediate(() => req.socket.destroy());
+}));
+
+app.listen(0, mustCall(() => {
+  const session = http2.connect(`http://localhost:${app.address().port}`);
+  const request = session.request({
+    [HTTP2_HEADER_PATH]: '/',
+    [HTTP2_HEADER_METHOD]: 'get'
+  });
+  request.once('response', mustCall((headers, flags) => {
+    let data = '';
+    request.on('data', (chunk) => { data += chunk; });
+    request.on('end', mustCall(() => {
+      assert.strictEqual(data, 'hello');
+      session.close();
+      app.close();
+    }));
+  }));
+  request.end();
+}));