diff --git a/lib/_stream_readable.js b/lib/_stream_readable.js
index afe3b3baf065c2..dde1eb500a782d 100644
--- a/lib/_stream_readable.js
+++ b/lib/_stream_readable.js
@@ -740,6 +740,7 @@ function resume_(stream, state) {
   }
 
   state.resumeScheduled = false;
+  state.awaitDrain = 0;
   stream.emit('resume');
   flow(stream);
   if (state.flowing && !state.reading)
diff --git a/test/parallel/test-stream-pipe-await-drain-manual-resume.js b/test/parallel/test-stream-pipe-await-drain-manual-resume.js
new file mode 100644
index 00000000000000..33540b47b3d5e3
--- /dev/null
+++ b/test/parallel/test-stream-pipe-await-drain-manual-resume.js
@@ -0,0 +1,54 @@
+'use strict';
+const common = require('../common');
+const stream = require('stream');
+
+// A consumer stream with a very low highWaterMark, which starts in a state
+// where it buffers the chunk it receives rather than indicating that they
+// have been consumed.
+const writable = new stream.Writable({
+  highWaterMark: 5
+});
+
+let isCurrentlyBufferingWrites = true;
+const queue = [];
+
+writable._write = (chunk, encoding, cb) => {
+  if (isCurrentlyBufferingWrites)
+    queue.push({chunk, cb});
+  else
+    cb();
+};
+
+const readable = new stream.Readable({
+  read() {}
+});
+
+readable.pipe(writable);
+
+readable.once('pause', common.mustCall(() => {
+  // First pause, resume manually. The next write() to writable will still
+  // return false, because chunks are still being buffered, so it will increase
+  // the awaitDrain counter again.
+  process.nextTick(common.mustCall(() => {
+    readable.resume();
+  }));
+
+  readable.once('pause', common.mustCall(() => {
+    // Second pause, handle all chunks from now on. Once all callbacks that
+    // are currently queued up are handled, the awaitDrain drain counter should
+    // fall back to 0 and all chunks that are pending on the readable side
+    // should be flushed.
+    isCurrentlyBufferingWrites = false;
+    for (const queued of queue)
+      queued.cb();
+  }));
+}));
+
+readable.push(Buffer.alloc(100));  // Fill the writable HWM, first 'pause'.
+readable.push(Buffer.alloc(100));  // Second 'pause'.
+readable.push(Buffer.alloc(100));  // Should get through to the writable.
+readable.push(null);
+
+writable.on('finish', common.mustCall(() => {
+  // Everything okay, all chunks were written.
+}));