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#CORASON-BGC
by Cruz-Morales Pablo and Sélem-Mojica Nelly
CORASON is a visual tool that searches for gene clusters similar to a given one, if exists a genomic core on this clusters CORASON finds it and sort them phylogenetically according to its core. CORASON outputs are SVG files, newick trees, and core functional report.
- Usage
Please consult [Installation guide] (https://github.com/nselem/EvoDivMet/blob/master/README.md) and Tutorial - Introduction
Given a reference cluster CORASON helps you find similar clusters colouring them according to its identity percentage. Starting with a query protein sequence that belongs to a query-cluster CORASON will find on a Bacterial genome database, hit-clusters with an ortholog of the query-protein and that in addition, this hit-clusters contains at least another sequence with an ortholog on the query-cluster. If exists a genomic core of hit-clusters its sequences will be concatenated and a phylogenetic tree will be constructed according to this aminoacid matrix, finally a report about enzyme core functionality will be provided.
Corason is a tool to prioritize how CORASON may be used to identify variations on natural products, after EvoMining, once detected an expantion on central pathways that %/)
[Evomining] (http://148.247.230.39/newevomining/new/evomining_web/index.html) is a functional phylogenomics method for identification of expanded, repurposed enzyme families, with the potential to catalyze new conversions in natural product biosynthesis.
[EvoMining: biosynthetic gene clusters allows discovery of arseno-organic metabolites] (http://gbe.oxfordjournals.org/content/early/2016/06/10/gbe.evw125.abstract)
[Evomining news] (https://codigof.mx/evomining-plataforma-bioinformatica-mexicano-desarrollar-nuevos-antibioticos/)
[Ziemert et al, June 2016] (http://pubs.rsc.org/en/Content/ArticleLanding/2016/NP/C6NP00025H#!divAbstract)
[Marnix & Fischbach, 2015] (http://www.nature.com/nchembio/journal/v11/n9/full/nchembio.1884.html)
[The Secondary Metabolite Bioinformatics Portal] (http://www.secondarymetabolites.org/mining/)
