diff --git a/CHANGELOG.md b/CHANGELOG.md
index 05ae64c1531..a7baa168d72 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -7,6 +7,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ## Unreleased
 
+- Standardizing timeout calculation in measurement consumer collect to nanoseconds
+  ([#4074](https://github.com/open-telemetry/opentelemetry-python/pull/4074))
 - optional scope attributes for logger creation
   ([#4035](https://github.com/open-telemetry/opentelemetry-python/pull/4035))
 - optional scope attribute for tracer creation
diff --git a/opentelemetry-sdk/src/opentelemetry/sdk/metrics/_internal/measurement_consumer.py b/opentelemetry-sdk/src/opentelemetry/sdk/metrics/_internal/measurement_consumer.py
index c5e81678dcb..4310061b823 100644
--- a/opentelemetry-sdk/src/opentelemetry/sdk/metrics/_internal/measurement_consumer.py
+++ b/opentelemetry-sdk/src/opentelemetry/sdk/metrics/_internal/measurement_consumer.py
@@ -100,18 +100,18 @@ def collect(
             metric_reader_storage = self._reader_storages[metric_reader]
             # for now, just use the defaults
             callback_options = CallbackOptions()
-            deadline_ns = time_ns() + timeout_millis * 10**6
+            deadline_ns = time_ns() + (timeout_millis * 1e6)
 
-            default_timeout_millis = 10000 * 10**6
+            default_timeout_ns = 10000 * 1e6
 
             for async_instrument in self._async_instruments:
 
                 remaining_time = deadline_ns - time_ns()
 
-                if remaining_time < default_timeout_millis:
+                if remaining_time < default_timeout_ns:
 
                     callback_options = CallbackOptions(
-                        timeout_millis=remaining_time
+                        timeout_millis=remaining_time / 1e6
                     )
 
                 measurements = async_instrument.callback(callback_options)
diff --git a/opentelemetry-sdk/tests/metrics/test_measurement_consumer.py b/opentelemetry-sdk/tests/metrics/test_measurement_consumer.py
index 19c514c13e8..91a49955b70 100644
--- a/opentelemetry-sdk/tests/metrics/test_measurement_consumer.py
+++ b/opentelemetry-sdk/tests/metrics/test_measurement_consumer.py
@@ -182,5 +182,5 @@ def sleep_1(*args, **kwargs):
 
         self.assertLess(
             callback_options_time_call,
-            10000 * 10**6,
+            10000,
         )