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KEGG_JAK-STAT.txt
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KEGG_JAK-STAT.txt
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CNTF_CTF1_CLCF1_IL27_IL6_IL11_IL13_IL31_LIF_OSM binds Rec <--> IL13_Rec || fixed CNTF_CTF1_CLCF1_IL27_IL6_IL11_IL13_IL31_LIF_OSM=0, Rec=1.3
IL13_Rec is phosphorylated <-> a_Rec
a_Rec activates JAK1_JAK2_CNTFR_IL31RA_IL4R_IL6R_IL6ST_IL11RA_IL13RA1_IL13RA2_LIFR_OSMR_TYK2 -> a_JAK1_JAK2_CNTFR_IL31RA_IL4R_IL6R_IL6ST_IL11RA_IL13RA1_IL13RA2_LIFR_OSMR_TYK2 || JAK1_JAK2_CNTFR_IL31RA_IL4R_IL6R_IL6ST_IL11RA_IL13RA1_IL13RA2_LIFR_OSMR_TYK2=2.8
a_Rec is degraded | kf=0.001
a_JAK1_JAK2_CNTFR_IL31RA_IL4R_IL6R_IL6ST_IL11RA_IL13RA1_IL13RA2_LIFR_OSMR_TYK2 is deactivated -> JAK1_JAK2_CNTFR_IL31RA_IL4R_IL6R_IL6ST_IL11RA_IL13RA1_IL13RA2_LIFR_OSMR_TYK2
a_JAK1_JAK2_CNTFR_IL31RA_IL4R_IL6R_IL6ST_IL11RA_IL13RA1_IL13RA2_LIFR_OSMR_TYK2 phosphorylates STAT -> a_STAT || STAT=165
PTPN6 dephosphorylates a_JAK1_JAK2_CNTFR_IL31RA_IL4R_IL6R_IL6ST_IL11RA_IL13RA1_IL13RA2_LIFR_OSMR_TYK2 -> JAK1_JAK2_CNTFR_IL31RA_IL4R_IL6R_IL6ST_IL11RA_IL13RA1_IL13RA2_LIFR_OSMR_TYK2 | V=0.001 | fixed PTPN6=91
a_STAT is deactivated -> STAT
a_STAT transcribes SOCSmRNA | V=0.01, K=50
SOCSmRNA is translated into SOCS4_SOCS7_SOCS1_SOCS2_SOCS3_SOCS6_SOCS5 | kf=10
SOCS4_SOCS7_SOCS1_SOCS2_SOCS3_SOCS6_SOCS5 is degraded
SOCS4_SOCS7_SOCS1_SOCS2_SOCS3_SOCS6_SOCS5 deactivates a_JAK1_JAK2_CNTFR_IL31RA_IL4R_IL6R_IL6ST_IL11RA_IL13RA1_IL13RA2_LIFR_OSMR_TYK2 -> JAK1_JAK2_CNTFR_IL31RA_IL4R_IL6R_IL6ST_IL11RA_IL13RA1_IL13RA2_LIFR_OSMR_TYK2 | V=0.001
# observable layer
@obs IL13_stimulation: u[CNTF_CTF1_CLCF1_IL27_IL6_IL11_IL13_IL31_LIF_OSM]
@obs RacSurf: u[Rec] + u[IL13_Rec] + u[a_Rec]
@obs IL13_cell: 5.56750 * (u[IL13_Rec] + u[a_Rec])
@obs pIL4Ra: 1.88700 * u[a_Rec]
@obs pJAK2: 1.39040 * u[a_JAK1_JAK2_CNTFR_IL31RA_IL4R_IL6R_IL6ST_IL11RA_IL13RA1_IL13RA2_LIFR_OSMR_TYK2]
@obs SOCS3mRNA: 17.66990 * u[SOCSmRNA]
@obs SOCS3: u[SOCS4_SOCS7_SOCS1_SOCS2_SOCS3_SOCS6_SOCS5]
@obs pSTAT5: u[a_STAT]
# simulation layer
@sim tspan: [0, 120]
@sim unperturbed: init[CNTF_CTF1_CLCF1_IL27_IL6_IL11_IL13_IL31_LIF_OSM] = 0
@sim condition IL13_4: init[CNTF_CTF1_CLCF1_IL27_IL6_IL11_IL13_IL31_LIF_OSM] = 4.0
@sim condition IL13_20: init[CNTF_CTF1_CLCF1_IL27_IL6_IL11_IL13_IL31_LIF_OSM] = 20.0