Raia2011_original.txt

IL13 binds Rec <--> IL13_Rec | kf=0.00342, const kr=0.0 | fixed IL13=0.0, Rec=1.3
@rxn JAK2 --> pJAK2: p[V2] * u[JAK2] * u[IL13_Rec] / (1 + p[K2] * u[SOCS3]) + p[V2] * u[JAK2] * u[p_IL13_Rec] / (1 + p[K2] * u[SOCS3]) | V2=0.15706, K2=0.01683 | JAK2=2.8
# The user-defined rate law above covers the following three reactions:
# IL13_Rec phosphorylates JAK2 --> pJAK2
# p_IL13_Rec phosphorylates JAK2 --> pJAK2
# SOCS3 inhibits JAK2 phosphorylation
pJAK2 phosphorylates IL13_Rec --> p_IL13_Rec | V=999.63100, K=1.0
pJAK2 phosphorylates STAT5 --> pSTAT5 | V=0.03826e+4, K=1.0e+4 | STAT5=165
pSTAT5 transcribes CD274mRNA | V=0.00008e+3, K=1.0e+3, const n=1.0
pSTAT5 transcribes SOCS3mRNA | V=0.00216e+3, K=1.0e+3, const n=1.0
SOCS3mRNA is translated into SOCS3 | kf=0.3
Rec <--> Rec_i | kf=0.10335, kr=0.00136 | Rec_i=113.19400
p_IL13_Rec -> p_IL13_Reci | kf=0.15254
p_IL13_Reci is degraded | kf=0.17292
IL13 binds DecoyR <--> IL13_DecoyR | kf=0.00012, const kr=0.0 | DecoyR=0.34
SHP1 dephosphorylates pJAK2 --> JAK2 | V=0.00062e+2, K=1.0e+2| fixed SHP1=91
SHP1 dephosphorylates pSTAT5 --> STAT5 | V=0.00034e+3, K=1.0e+3
SOCS3 is degraded | kf=0.04292

# observable layer
@obs IL13_stimulation: u[IL13]
@obs RacSurf: u[Rec] + u[IL13_Rec] + u[p_IL13_Rec]
@obs IL13_cell: 5.56750 * (u[IL13_Rec] + u[p_IL13_Rec] + u[p_IL13_Reci] + u[IL13_DecoyR])
@obs pIL4Ra: 1.88700 * (u[p_IL13_Rec] + u[p_IL13_Reci])
@obs pJAK2: 1.39040 * u[pJAK2]
@obs SOCS3mRNA: 17.66990 * u[SOCS3mRNA]
@obs CD274mRNA: u[CD274mRNA]
@obs SOCS3: u[SOCS3]
@obs pSTAT5: u[pSTAT5]

# simulation layer
@sim tspan: [0, 120]
@sim condition IL13_4: init[IL13] = 4.0
@sim condition IL13_20: init[IL13] = 20.0