diff --git a/CHANGELOG.md b/CHANGELOG.md
index 410d2d87013..762553cd630 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,10 @@
 
 ## Unreleased
 
+### 💡 Enhancements 💡
+
+- Add validation to check at least one endpoint is specified in otlphttpexporter's configuration (#4860)
+
 ## v0.45.0 Beta
 
 ### 🛑 Breaking changes 🛑
diff --git a/exporter/otlphttpexporter/config.go b/exporter/otlphttpexporter/config.go
index ecd03695f31..31987e1e27a 100644
--- a/exporter/otlphttpexporter/config.go
+++ b/exporter/otlphttpexporter/config.go
@@ -15,6 +15,8 @@
 package otlphttpexporter // import "go.opentelemetry.io/collector/exporter/otlphttpexporter"
 
 import (
+	"fmt"
+
 	"go.opentelemetry.io/collector/config"
 	"go.opentelemetry.io/collector/config/confighttp"
 	"go.opentelemetry.io/collector/exporter/exporterhelper"
@@ -41,5 +43,8 @@ var _ config.Exporter = (*Config)(nil)
 
 // Validate checks if the exporter configuration is valid
 func (cfg *Config) Validate() error {
+	if cfg.Endpoint == "" && cfg.TracesEndpoint == "" && cfg.MetricsEndpoint == "" && cfg.LogsEndpoint == "" {
+		return fmt.Errorf("at least one endpoint must be specified")
+	}
 	return nil
 }
diff --git a/exporter/otlphttpexporter/config_test.go b/exporter/otlphttpexporter/config_test.go
index 6ad133f8c25..c751cf2c7c6 100644
--- a/exporter/otlphttpexporter/config_test.go
+++ b/exporter/otlphttpexporter/config_test.go
@@ -36,14 +36,21 @@ func TestLoadConfig(t *testing.T) {
 
 	factory := NewFactory()
 	factories.Exporters[typeStr] = factory
-	cfg, err := servicetest.LoadConfigAndValidate(filepath.Join("testdata", "config.yaml"), factories)
 
-	require.NoError(t, err)
-	require.NotNil(t, cfg)
+	// Bad config
+	cfg, err := servicetest.LoadConfigAndValidate(filepath.Join("testdata", "bad_empty_config.yaml"), factories)
+
+	require.Error(t, err)
 
 	e0 := cfg.Exporters[config.NewComponentID(typeStr)]
 	assert.Equal(t, e0, factory.CreateDefaultConfig())
 
+	// Good config
+	cfg, err = servicetest.LoadConfigAndValidate(filepath.Join("testdata", "config.yaml"), factories)
+
+	require.NoError(t, err)
+	require.NotNil(t, cfg)
+
 	e1 := cfg.Exporters[config.NewComponentIDWithName(typeStr, "2")]
 	assert.Equal(t, e1,
 		&Config{
diff --git a/exporter/otlphttpexporter/testdata/bad_empty_config.yaml b/exporter/otlphttpexporter/testdata/bad_empty_config.yaml
new file mode 100644
index 00000000000..c52b900bbe9
--- /dev/null
+++ b/exporter/otlphttpexporter/testdata/bad_empty_config.yaml
@@ -0,0 +1,15 @@
+receivers:
+  nop:
+
+processors:
+  nop:
+
+exporters:
+  otlphttp:
+
+service:
+  pipelines:
+    traces:
+      receivers: [nop]
+      processors: [nop]
+      exporters: [otlphttp]
diff --git a/exporter/otlphttpexporter/testdata/config.yaml b/exporter/otlphttpexporter/testdata/config.yaml
index 61de8891da9..3d48e47f57a 100644
--- a/exporter/otlphttpexporter/testdata/config.yaml
+++ b/exporter/otlphttpexporter/testdata/config.yaml
@@ -5,7 +5,6 @@ processors:
   nop:
 
 exporters:
-  otlphttp:
   otlphttp/2:
     endpoint: "https://1.2.3.4:1234"
     tls:
@@ -36,4 +35,4 @@ service:
     traces:
       receivers: [nop]
       processors: [nop]
-      exporters: [otlphttp]
+      exporters: [otlphttp/2]