diff --git a/.chloggen/issue-3412-support-http-protocol.yaml b/.chloggen/issue-3412-support-http-protocol.yaml
new file mode 100755
index 0000000000..6237be1212
--- /dev/null
+++ b/.chloggen/issue-3412-support-http-protocol.yaml
@@ -0,0 +1,16 @@
+# One of 'breaking', 'deprecation', 'new_component', 'enhancement', 'bug_fix'
+change_type: enhancement
+
+# The name of the component, or a single word describing the area of concern, (e.g. collector, target allocator, auto-instrumentation, opamp, github action)
+component: auto-instrumentation
+
+# A brief description of the change. Surround your text with quotes ("") if it needs to start with a backtick (`).
+note: Support `http/json` and `http/protobuf` via OTEL_EXPORTER_OTLP_PROTOCOL environment variable in addition to default `grpc` for exporting traces
+
+# One or more tracking issues related to the change
+issues: [3412]
+
+# (Optional) One or more lines of additional information to render under the primary note.
+# These lines will be padded with 2 spaces and then inserted directly into the document.
+# Use pipe (|) for multiline entries.
+subtext:
diff --git a/autoinstrumentation/nodejs/src/autoinstrumentation.ts b/autoinstrumentation/nodejs/src/autoinstrumentation.ts
index 2db79465b0..2a4aabc4a7 100644
--- a/autoinstrumentation/nodejs/src/autoinstrumentation.ts
+++ b/autoinstrumentation/nodejs/src/autoinstrumentation.ts
@@ -1,4 +1,6 @@
 import { getNodeAutoInstrumentations } from '@opentelemetry/auto-instrumentations-node';
+import { OTLPTraceExporter as OTLPProtoTraceExporter } from '@opentelemetry/exporter-trace-otlp-proto';
+import { OTLPTraceExporter as OTLPHttpTraceExporter } from '@opentelemetry/exporter-trace-otlp-http';
 import { OTLPTraceExporter as OTLPGrpcTraceExporter } from '@opentelemetry/exporter-trace-otlp-grpc';
 import { OTLPMetricExporter } from '@opentelemetry/exporter-metrics-otlp-grpc';
 import { PrometheusExporter } from '@opentelemetry/exporter-prometheus';
@@ -13,7 +15,19 @@ import { diag } from '@opentelemetry/api';
 import { NodeSDK } from '@opentelemetry/sdk-node';
 
 function getTraceExporter() {
+    let protocol = process.env.OTEL_EXPORTER_OTLP_PROTOCOL;
+    switch (protocol) {
+        case undefined:
+        case '':
+        case 'grpc':
             return new OTLPGrpcTraceExporter();
+        case 'http/json':
+            return new OTLPHttpTraceExporter();
+        case 'http/protobuf':
+            return new OTLPProtoTraceExporter();
+        default:
+            throw Error(`Creating traces exporter based on "${protocol}" protocol (configured via environment variable OTEL_EXPORTER_OTLP_PROTOCOL) is not implemented!`);
+    }
 }
 
 function getMetricReader() {