diff --git a/CHANGELOG.md b/CHANGELOG.md
index fb7c3fd87322..75f4ad381df2 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -238,6 +238,7 @@ Inspired from [Keep a Changelog](https://keepachangelog.com/en/1.0.0/)
 - [Multi DataSource] UX enhancement on Data source management stack ([#2521](https://github.com/opensearch-project/OpenSearch-Dashboards/pull/2521))
 - [Multi DataSource] UX enhancement on Update stored password modal for Data source management stack ([#2532](https://github.com/opensearch-project/OpenSearch-Dashboards/pull/2532))
 - [Monaco editor] Add json worker support ([#3424](https://github.com/opensearch-project/OpenSearch-Dashboards/pull/3424))
+- Replace re2 with RegExp in timeline and add unit tests ([#3908](https://github.com/opensearch-project/OpenSearch-Dashboards/pull/3908))
 
 ### 🐛 Bug Fixes
 
diff --git a/src/plugins/vis_type_timeline/server/series_functions/label.js b/src/plugins/vis_type_timeline/server/series_functions/label.js
index c935d537081f..4649ee6cf53f 100644
--- a/src/plugins/vis_type_timeline/server/series_functions/label.js
+++ b/src/plugins/vis_type_timeline/server/series_functions/label.js
@@ -62,10 +62,8 @@ export default new Chainable('label', {
     const config = args.byName;
     return alter(args, function (eachSeries) {
       if (config.regex) {
-        // not using a standard `import` so that if there's an issue with the re2 native module
-        // that it doesn't prevent OpenSearch Dashboards from starting up and we only have an issue using Timeline labels
-        const RE2 = require('re2');
-        eachSeries.label = eachSeries.label.replace(new RE2(config.regex), config.label);
+        const regex = new RegExp(config.regex);
+        eachSeries.label = eachSeries.label.replace(regex, config.label);
       } else {
         eachSeries.label = config.label;
       }
diff --git a/src/plugins/vis_type_timeline/server/series_functions/label.test.js b/src/plugins/vis_type_timeline/server/series_functions/label.test.js
index c6dc832914a3..69268b385b07 100644
--- a/src/plugins/vis_type_timeline/server/series_functions/label.test.js
+++ b/src/plugins/vis_type_timeline/server/series_functions/label.test.js
@@ -51,4 +51,24 @@ describe('label.js', () => {
       expect(r.output.list[0].label).to.equal('beerative');
     });
   });
+
+  it('can use a regex to capture groups to modify series label', () => {
+    return invoke(fn, [seriesList, 'beer$2', '(N)(egative)']).then((r) => {
+      expect(r.output.list[0].label).to.equal('beeregative');
+    });
+  });
+
+  it('can handle different regex patterns', () => {
+    const seriesListCopy1 = JSON.parse(JSON.stringify(seriesList));
+    const seriesListCopy2 = JSON.parse(JSON.stringify(seriesList));
+
+    return Promise.all([
+      invoke(fn, [seriesListCopy1, 'beer$1 - $2', '(N)(egative)']).then((r) => {
+        expect(r.output.list[0].label).to.equal('beerN - egative');
+      }),
+      invoke(fn, [seriesListCopy2, 'beer$1_$2', '(N)(eg.*)']).then((r) => {
+        expect(r.output.list[0].label).to.equal('beerN_egative');
+      }),
+    ]);
+  });
 });
diff --git a/yarn.lock b/yarn.lock
index 33ca05a2f2c1..67eb2e4b3bdd 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -4155,7 +4155,16 @@ agentkeepalive@^3.4.1:
   dependencies:
     humanize-ms "^1.2.1"
 
-agentkeepalive@^4.1.3, agentkeepalive@^4.2.1:
+agentkeepalive@^4.1.3:
+  version "4.3.0"
+  resolved "https://registry.yarnpkg.com/agentkeepalive/-/agentkeepalive-4.3.0.tgz#bb999ff07412653c1803b3ced35e50729830a255"
+  integrity sha512-7Epl1Blf4Sy37j4v9f9FjICCh4+KAQOyXgHEwlyBiAQLbhKdq/i2QQU3amQalS/wPhdPzDXPL5DMR5bkn+YeWg==
+  dependencies:
+    debug "^4.1.0"
+    depd "^2.0.0"
+    humanize-ms "^1.2.1"
+
+agentkeepalive@^4.2.1:
   version "4.2.1"
   resolved "https://registry.yarnpkg.com/agentkeepalive/-/agentkeepalive-4.2.1.tgz#a7975cbb9f83b367f06c90cc51ff28fe7d499717"
   integrity sha512-Zn4cw2NEqd+9fiSVWMscnjyQ1a8Yfoc5oBajLeo5w+YBHgDUcEBY2hS4YpTz6iN5f/2zQiktcuM6tS8x1p9dpA==
@@ -6889,7 +6898,7 @@ delayed-stream@~1.0.0:
 delegates@^1.0.0:
   version "1.0.0"
   resolved "https://registry.yarnpkg.com/delegates/-/delegates-1.0.0.tgz#84c6e159b81904fdca59a0ef44cd870d31250f9a"
-  integrity sha1-hMbhWbgZBP3KWaDvRM2HDTElD5o=
+  integrity sha512-bd2L678uiWATM6m5Z1VzNCErI3jiGzt6HGY8OVICs40JQq/HALfbyNJmp0UDakEY4pMMaN0Ly5om/B1VI/+xfQ==
 
 delete-empty@^2.0.0:
   version "2.0.0"
@@ -6905,6 +6914,11 @@ depd@^1.1.2:
   resolved "https://registry.yarnpkg.com/depd/-/depd-1.1.2.tgz#9bcd52e14c097763e749b274c4346ed2e560b5a9"
   integrity sha1-m81S4UwJd2PnSbJ0xDRu0uVgtak=
 
+depd@^2.0.0:
+  version "2.0.0"
+  resolved "https://registry.yarnpkg.com/depd/-/depd-2.0.0.tgz#b696163cc757560d09cf22cc8fad1571b79e76df"
+  integrity sha512-g7nH6P6dyDioJogAAGprGpCtVImJhpPk/roCzdb3fIh61/s/nPsfR6onyMwkCAR/OlC3yBC0lESvUoQEAssIrw==
+
 dependency-check@^4.1.0:
   version "4.1.0"
   resolved "https://registry.yarnpkg.com/dependency-check/-/dependency-check-4.1.0.tgz#d45405cabb50298f8674fe28ab594c8a5530edff"
@@ -9980,9 +9994,9 @@ inquirer@^7.0.0, inquirer@^7.3.3:
     through "^2.3.6"
 
 install-artifact-from-github@^1.3.0:
-  version "1.3.1"
-  resolved "https://registry.yarnpkg.com/install-artifact-from-github/-/install-artifact-from-github-1.3.1.tgz#eefaad9af35d632e5d912ad1569c1de38c3c2462"
-  integrity sha512-3l3Bymg2eKDsN5wQuMfgGEj2x6l5MCAv0zPL6rxHESufFVlEAKW/6oY9F1aGgvY/EgWm5+eWGRjINveL4X7Hgg==
+  version "1.3.2"
+  resolved "https://registry.yarnpkg.com/install-artifact-from-github/-/install-artifact-from-github-1.3.2.tgz#1a16d9508e40330523a3017ae0d4713ccc64de82"
+  integrity sha512-yCFcLvqk0yQdxx0uJz4t9Z3adDMLAYrcGYv546uRXCSvxE+GqNYhhz/KmrGcUKGI/gVLR9n/e/zM9jX/+ASMJQ==
 
 internal-slot@^1.0.3:
   version "1.0.3"