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data-zanim-trigger="scroll"> <img class="fit-cover vh-lg-100" src="assets/img/hp_qinan1.jpg" alt="A photo of Qinan on Willis Tower"> <img class="fit-cover vh-lg-100" src="assets/img/hp_qinan2.jpg" alt="A photo of Qinan making a cake"> <img class="fit-cover vh-lg-100" src="assets/img/hp_qinan3.jpg" alt="A wedding photo of Qinan and Kexin"> </div>
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<h1 data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">胡琪楠</h1>
<div data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll"><a href="mailto:qh78@cornell.edu">
<p class="lead text-sans-serif font-weight-normal text-600">qh78@cornell.edu</p>
</a></div>
<p class="lead text-sans-serif font-weight-normal text-600" data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">(+01) 607-379-7405 | (+86)13776865917</p>
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<h2 id="education">教育经历</h2>
</div>
<div class="row mt-4" data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">
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<h3>美国康奈尔大学 (Cornell University)</h3>
<h4>博士 2014-2020</h4>
<p class="lead text-sans-serif font-weight-normal text-600">主专业：分子生物学</p>
<p class="lead text-sans-serif font-weight-normal text-600" >副专业：发育生物学</p>
<h3>北京大学</h3>
<h4>理学学士 2010-2014</h4>
<p class="lead text-sans-serif font-weight-normal text-600">专业：生物科学</p>
</div>
</div>
</div>
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<h2 id="research">研究经历</h2>
</div>
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<div class="col-xl-10">
<div class="overflow-hidden">
<h3 class="font-hei" data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">发表论文</h3>
<ul data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">
<li><b>Hu, Q.</b> and Wolfner, M.F., 2019. The <em>Drosophila</em> Trpm channel mediates calcium influx during egg activation. <em>Proceedings of the National Academy of Sciences, 116</em>(38), pp.18994-19000.</li>
<li>York-Andersen, A.H.*, <b>Hu, Q.*</b>, Wood, B., Wolfner M.F., Weil, T.T. A calcium mediated actin redistribution at egg activation in <em>Drosophila</em> <span class="font-hei">（审议中） <b>*共同一作。</b></span></li>
</ul>
<h3 data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">博士学位论文（2014 至今）</h3>
<p class="font-hei" data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">《果蝇卵的激活机制和下游信号通路》</p>
<p class="font-hei" data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">导师：<a href="https://mbg.cornell.edu/people/mariana-wolfner/" target="_blank">Mariana Wolfner 教授</a>，美国康奈尔大学</p>
<div class="row" data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">
<div class="col-md-6">
<ul>
<li class="font-hei">综合运用了药物抑制剂、生殖细胞系RNAi敲低和CRISPR/Cas9敲除技术，发现了Trpm蛋白是果蝇卵激活过程中介导钙离子进入细胞的通道。</li>
</ul>
</div>
<div class="col-md-6" data-zanim-xs='{"delay":0.1,"animation":"zoom-in"}' data-zanim-trigger="scroll">
<figure class="figure text-center"> <img src="assets/img/h_trpm.jpg" class="img-fluid rounded" alt="The calcium wave during fruit fly egg activation">
<figcaption class="figure-caption font-hei" data-zanim-xs='{"delay":0.3}'><em>果蝇卵激活过程中的钙波，Kaneuchi et al., 2015</em></figcaption>
</figure>
</div>
</div>
<ul data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">
<li class="font-hei">优化了钙离子指示蛋白在果蝇生殖细胞系中的表达，并用共聚焦显微镜和激光片层扫描显微镜观测了果蝇卵激活过程中的钙离子动态。</li>
<li class="font-hei">开发并优化了高效的CRISPR/Cas9介导的果蝇生殖细胞系敲除和敲入技术（和美国康奈尔大学 <a href="https://mbg.cornell.edu/people/chun-han" target="_blank">Chun Han 教授</a>合作项目）。</li>
</ul>
<div class="row">
<div class="col-md-6" data-zanim-xs='{"delay":0.3}' data-zanim-trigger="scroll">
<ul>
<li class="font-hei">用显微操作针和微流体室检测了果蝇卵母细胞的机械力敏感性（和美国康奈尔大学 <a href="https://www.bme.cornell.edu/faculty-directory/jan-lammerding" target="_blank">Jan Lammerding 教授</a>以及<a href="https://www.ncat.edu/cost/research/phys/people/tung/index.html" target="_blank">Chih-kuan Tung 教授</a>合作项目）。</li>
</ul>
</div>
<div class="col-md-6" data-zanim-xs='{"delay":0.1,"animation":"zoom-in"}' data-zanim-trigger="scroll">
<figure class="figure text-center"> <img src="assets/img/h_microneedle.jpg" class="img-fluid rounded" alt="The calcium rise in fruit fly egg induced by microneedle">
<figcaption class="figure-caption font-hei" data-zanim-xs='{"delay":0.3}'><em>显微操作针在果蝇卵母细胞上引发的区域性钙离子浓度上升</em></figcaption>
</figure>
</div>
</div>
<ul data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">
<li class="font-hei">发现了果蝇卵激活过程中的肌动蛋白重组波，及其和钙波的相互调控机制（和英国剑桥大学 <a href="https://www.zoo.cam.ac.uk/directory/dr-timothy-weil" target="_blank">Timothy Weil 教授</a>合作项目）。</li>
</ul>
<div class="row" data-zanim-xs='{"delay":0.3}' data-zanim-trigger="scroll">
<div class="col-md-6">
<ul>
<li class="font-hei">使用Argonne国家实验室的X光荧光显微镜检测了果蝇卵激活过程中包括锌在内的金属元素含量和分布变化（和美国西北大学 <a href="https://www.feinberg.northwestern.edu/sites/obgyn/faculty/profile.html?xid=26852" target="_blank">Francesca Duncan 教授</a>, <a href="https://www.tgs.northwestern.edu/about/contact/bios/teresa-woodruff.html" target="_blank">Teresa Woodruff 教授</a>以及<a href="https://www.chemistry.northwestern.edu/people/core-faculty/profiles/thomas-ohalloran.html" target="_blank">Thomas O’Halloran 教授</a>合作项目）。</li>
</ul>
</div>
<div class="col-md-6" data-zanim-xs='{"delay":0.1,"animation":"zoom-in"}' data-zanim-trigger="scroll">
<figure class="figure text-center"> <img src="assets/img/h_xfm.jpg" class="img-fluid rounded" alt="X-ray fluorescence microscopy image showing the distribution of an element in fruit fly oocyte">
<figcaption class="figure-caption font-hei" data-zanim-xs='{"delay":0.3}'><em>X光荧光显微镜下果蝇卵母细胞内某元素的分布</em></figcaption>
</figure>
</div>
</div>
<h3 data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">学士学位论文（2013 – 2014）</h3>
<p class="font-hei" data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">《DNA结合蛋白JBP1羟化酶结构域的的纯化和活性分析》</p>
<p class="font-hei" data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">导师：<a href="http://www.cls.edu.cn/english/PrincipalInvestigator/pi/index1608.shtml" target="_blank">伊成器教授</a>，北京大学</p>
<ul data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">
<li class="font-hei">设计合成了7个JBP1催化结构域的截断蛋白表达载体。</li>
<li class="font-hei">尝试了多种方法纯化不可溶蛋白。</li>
<li class="font-hei">成功纯化了2个MBP融合截断蛋白并用HPLC检测了其活性。</li>
</ul>
<h3 data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">暑期研究实习（2013）</h3>
<p class="font-hei" data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">《营养缺乏诱导的自噬条件下MAP4K3介导的TFEB蛋白磷酸化研究》</p>
<p class="font-hei" data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">导师：<a href="https://medschool.ucsd.edu/education/neurograd/faculty/Pages/albert-spada.aspx" target="_blank">Albert La Spada 教授</a>，美国加州大学圣地亚哥分校</p>
<ul data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">
<li class="font-hei">优化了TFEB和溶酶体免疫荧光显微成像和共定位技术。</li>
<li class="font-hei">分析了TFEB serine 3位置的仿磷酸化效应。</li>
<li class="font-hei">使用免疫共沉淀筛选了3个MAP4K3可能的相互作用蛋白。</li>
</ul>
<h3 data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">学术交流</h3>
<ul data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">
<li><span class="font-hei">海报：</span> “The trigger and consequences of calcium influx during <em>Drosophila</em> egg activation”, Society for Developmental Biology 78th Annual Meeting, 2019</li>
<li><span class="font-hei">海报：</span>“Dissecting the triggers of calcium wave during <em>Drosophila</em> egg activation”, Cornell/Pittsburgh Reproductive Genomics Symposium, 2018</li>
<li><span class="font-hei">海报：</span>“Dissecting the triggers of calcium wave during <em>Drosophila</em> egg activation”, Gordon Research Conference for Fertilization and Activation of Development, 2017</li>
<li><span class="font-hei">海报：</span>“Dissecting the mechanisms of calcium wave during <em>Drosophila</em> egg activation”, The Allied Genetics Conference, 2016</li>
</ul>
</div>
</div>
</div>
</div>
<div class="overflow-hidden mt-5" data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">
<h2 id="experience">其他经历</h2>
</div>
<div class="row mt-4">
<div class="col-xl-10">
<h3 data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">获奖经历</h3>
<ul data-zanim-xs='{"delay":0.3}' data-zanim-trigger="scroll">
<li>George P. Hess <span class="font-hei">差旅经费奖，康奈尔大学， 2019</span></li>
<li>Mann <span class="font-hei">杰出研究生奖，入围，康奈尔大学， 2019</span></li>
<li class="font-hei">研究生院差旅经费奖，康奈尔大学， 2018</li>
<li class="font-hei">本科生科研项目，二等奖，北京大学， 2014</li>
</ul>
<h3 data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">学术指导</h3>
<ul data-zanim-xs='{"delay":0.3}' data-zanim-trigger="scroll">
<li>BioMG1350 <span class="font-hei">生物学导论：细胞和发育生物学课程助教, 2019.8 – 2019.12</span></li>
<li>“Choose Development!”<span class="font-hei">本科生暑期科研项目导师， 2018.6 – 2018.9 & 2019.6 - 2019.9</span></li>
<li>BioMG2801 <span class="font-hei">遗传学实验课程助教, 2016.1 – 2016.5</span></li>
</ul>
<h3 data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">编程技能</h3>
<ul data-zanim-xs='{"delay":0.3}' data-zanim-trigger="scroll">
<li>R</li>
<li>Python</li>
<li>MySQL</li>
<li>HTML5/CSS3</li>
</ul>
<h3 data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">专业技能培养</h3>
<ul data-zanim-xs='{"delay":0.3}' data-zanim-trigger="scroll">
<li class="font-hei">零基础网页设计入门，自学完成Coursera上美国密歇根大学开设的5门课的专精课程。<a href="https://www.coursera.org/account/accomplishments/specialization/S8UPW3R26MKY" target="_blank">专精证书</a>于2019年6月8日获得（HTML5, CSS3, JavaScript, 响应式网页设计）。</li>
<li class="font-hei">R语言环境软件开发， 自学完成Coursera上美国约翰霍普金斯大学开设的5门课的专精课程。<a href="https://www.coursera.org/account/accomplishments/specialization/75WGG7UMSK6Z" target="_blank">专精证书</a>于2019年4月30日获得 （面向对象程序设计，R数据包开发，可视化工具开发）。</li>
<li class="font-hei">Python数据科学导论，自学完成Coursera上美国密歇根大学开设的课程。<a href="https://www.coursera.org/account/accomplishments/verify/WZW4E7BPHR64" target="_blank">课程证书</a>于2019 年4月13日获得（Python编程，numpy数据包，pandas数据包）。</li>
<li class="font-hei">数据科学，自学完成Coursera上美国约翰霍普金斯大学开设的10门课的专精课程。<a href="https://www.coursera.org/account/accomplishments/specialization/43KBDWVWSCTB" target="_blank">专精证书</a>于2019年1月11日获得（R语言编程，数据分析，回归模型，markdown语言，实用机器学习，tidyverse数据包，ggplot2数据包）。</li>
<li class="font-hei">机器学习，自学完成Coursera上美国斯坦福大学开设的课程。<a href="https://www.coursera.org/account/accomplishments/records/T7ABHEPL244Y" target="_blank">课程证书</a>于2018年3月28日获得。</li>
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<h3 data-zanim-xs='{"delay":0.2}' data-zanim-trigger="scroll">媒体报道</h3>
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<li>康奈尔大学校刊： <a target="_blank" href="http://news.cornell.edu/stories/2019/09/ancient-pathway-uncovers-calciums-role-egg-development">Ancient pathway uncovers calcium’s role in egg development</a></li>
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