diff --git a/pkg/planner/core/plan_cache_utils.go b/pkg/planner/core/plan_cache_utils.go
index b3c5bbcded942..7fa772016880f 100644
--- a/pkg/planner/core/plan_cache_utils.go
+++ b/pkg/planner/core/plan_cache_utils.go
@@ -90,9 +90,13 @@ func GeneratePlanCacheStmtWithAST(ctx context.Context, sctx sessionctx.Context,
 		return nil, nil, 0, ErrPrepareDDL
 	}
 
-	switch paramStmt.(type) {
+	switch stmt := paramStmt.(type) {
 	case *ast.ImportIntoStmt, *ast.LoadDataStmt, *ast.PrepareStmt, *ast.ExecuteStmt, *ast.DeallocateStmt, *ast.NonTransactionalDMLStmt:
 		return nil, nil, 0, ErrUnsupportedPs
+	case *ast.SelectStmt:
+		if stmt.SelectIntoOpt != nil {
+			return nil, nil, 0, ErrUnsupportedPs
+		}
 	}
 
 	// Prepare parameters should NOT over 2 bytes(MaxUint16)
diff --git a/pkg/planner/core/plan_cacheable_checker_test.go b/pkg/planner/core/plan_cacheable_checker_test.go
index 533b8d1fc8334..62fc3578b7899 100644
--- a/pkg/planner/core/plan_cacheable_checker_test.go
+++ b/pkg/planner/core/plan_cacheable_checker_test.go
@@ -348,6 +348,14 @@ func TestCacheable(t *testing.T) {
 	require.True(t, core.Cacheable(stmt, is))
 }
 
+func TestIssue49166(t *testing.T) {
+	store := testkit.CreateMockStore(t)
+	tk := testkit.NewTestKit(t, store)
+	tk.MustExec("use test")
+	tk.MustExec(`create table t (c int)`)
+	tk.MustContainErrMsg(`prepare stmt from "select c from t limit 1 into outfile 'text'"`, "This command is not supported in the prepared statement protocol yet")
+}
+
 func TestNonPreparedPlanCacheable(t *testing.T) {
 	store := testkit.CreateMockStore(t)