diff --git a/store/tikv/2pc.go b/store/tikv/2pc.go
index a4d7b4f58e4e6..c0f7caa4a9d01 100644
--- a/store/tikv/2pc.go
+++ b/store/tikv/2pc.go
@@ -423,6 +423,9 @@ func txnLockTTL(startTime time.Time, txnSize int) uint64 {
 	return lockTTL + uint64(elapsed)
 }
 
+var preSplitDetectThreshold uint32 = 100000
+var preSplitSizeThreshold uint32 = 32 << 20
+
 // doActionOnMutations groups keys into primary batch and secondary batches, if primary batch exists in the key,
 // it does action on primary batch first, then on secondary batches. If action is commit, secondary batches
 // is done in background goroutine.
@@ -435,6 +438,68 @@ func (c *twoPhaseCommitter) doActionOnMutations(bo *Backoffer, action twoPhaseCo
 		return errors.Trace(err)
 	}
 
+	// Pre-split regions to avoid too much write workload into a single region.
+	// In the large transaction case, this operation is important to avoid TiKV 'server is busy' error.
+	var preSplited bool
+	preSplitDetectThresholdVal := atomic.LoadUint32(&preSplitDetectThreshold)
+	for _, group := range groups {
+		if uint32(group.mutations.len()) >= preSplitDetectThresholdVal {
+			logutil.BgLogger().Info("2PC detect large amount of mutations on a single region",
+				zap.Uint64("region", group.region.GetID()),
+				zap.Int("mutations count", group.mutations.len()))
+			// Use context.Background, this time should not add up to Backoffer.
+			if preSplitAndScatterIn2PC(context.Background(), c.store, group) {
+				preSplited = true
+			}
+		}
+	}
+	// Reload region cache again.
+	if preSplited {
+		groups, err = c.store.regionCache.GroupSortedMutationsByRegion(bo, mutations)
+		if err != nil {
+			return errors.Trace(err)
+		}
+	}
+
+	return c.doActionOnGroupMutations(bo, action, groups)
+}
+
+func preSplitAndScatterIn2PC(ctx context.Context, store *tikvStore, group groupedMutations) bool {
+	length := group.mutations.len()
+	splitKeys := make([][]byte, 0, 4)
+
+	preSplitSizeThresholdVal := atomic.LoadUint32(&preSplitSizeThreshold)
+	regionSize := 0
+	for i := 0; i < length; i++ {
+		regionSize = regionSize + len(group.mutations.keys[i]) + len(group.mutations.values[i])
+		// The second condition is used for testing.
+		if regionSize >= int(preSplitSizeThresholdVal) {
+			regionSize = 0
+			splitKeys = append(splitKeys, group.mutations.keys[i])
+		}
+	}
+	if len(splitKeys) == 0 {
+		return false
+	}
+
+	regionIDs, err := store.SplitRegions(ctx, splitKeys, true)
+	if err != nil {
+		logutil.BgLogger().Warn("2PC split regions failed", zap.Uint64("regionID", group.region.id), zap.Int("keys count", length), zap.Error(err))
+		return false
+	}
+
+	for _, regionID := range regionIDs {
+		err := store.WaitScatterRegionFinish(regionID, 0)
+		if err != nil {
+			logutil.BgLogger().Warn("2PC wait scatter region failed", zap.Uint64("regionID", regionID), zap.Error(err))
+		}
+	}
+	// Invalidate the old region cache information.
+	store.regionCache.InvalidateCachedRegion(group.region)
+	return true
+}
+
+func (c *twoPhaseCommitter) doActionOnGroupMutations(bo *Backoffer, action twoPhaseCommitAction, groups []groupedMutations) error {
 	action.tiKVTxnRegionsNumHistogram().Observe(float64(len(groups)))
 
 	var batches []batchMutations
@@ -467,6 +532,7 @@ func (c *twoPhaseCommitter) doActionOnMutations(bo *Backoffer, action twoPhaseCo
 	_, actionIsCleanup := action.(actionCleanup)
 	_, actionIsPessimiticLock := action.(actionPessimisticLock)
 
+	var err error
 	failpoint.Inject("skipKeyReturnOK", func(val failpoint.Value) {
 		valStr, ok := val.(string)
 		if ok && c.connID > 0 {
diff --git a/store/tikv/2pc_slow_test.go b/store/tikv/2pc_slow_test.go
index bf96a24485ac3..c7a70a188306e 100644
--- a/store/tikv/2pc_slow_test.go
+++ b/store/tikv/2pc_slow_test.go
@@ -15,7 +15,12 @@
 
 package tikv
 
-import . "github.com/pingcap/check"
+import (
+	"context"
+	"sync/atomic"
+
+	. "github.com/pingcap/check"
+)
 
 // TestCommitMultipleRegions tests commit multiple regions.
 // The test takes too long under the race detector.
@@ -35,3 +40,38 @@ func (s *testCommitterSuite) TestCommitMultipleRegions(c *C) {
 	}
 	s.mustCommit(c, m)
 }
+
+func (s *testTiclientSuite) TestSplitRegionIn2PC(c *C) {
+	const preSplitThresholdInTest = 500
+	old := atomic.LoadUint32(&preSplitDetectThreshold)
+	defer atomic.StoreUint32(&preSplitDetectThreshold, old)
+	atomic.StoreUint32(&preSplitDetectThreshold, preSplitThresholdInTest)
+
+	old = atomic.LoadUint32(&preSplitSizeThreshold)
+	defer atomic.StoreUint32(&preSplitSizeThreshold, old)
+	atomic.StoreUint32(&preSplitSizeThreshold, 5000)
+
+	bo := NewBackoffer(context.Background(), 1)
+	startKey := encodeKey(s.prefix, s08d("key", 0))
+	endKey := encodeKey(s.prefix, s08d("key", preSplitThresholdInTest))
+	checkKeyRegion := func(bo *Backoffer, start, end []byte, checker Checker) {
+		// Check regions after split.
+		loc1, err := s.store.regionCache.LocateKey(bo, start)
+		c.Assert(err, IsNil)
+		loc2, err := s.store.regionCache.LocateKey(bo, end)
+		c.Assert(err, IsNil)
+		c.Assert(loc1.Region.id, checker, loc2.Region.id)
+	}
+
+	// Check before test.
+	checkKeyRegion(bo, startKey, endKey, Equals)
+	txn := s.beginTxn(c)
+	for i := 0; i < preSplitThresholdInTest; i++ {
+		err := txn.Set(encodeKey(s.prefix, s08d("key", i)), valueBytes(i))
+		c.Assert(err, IsNil)
+	}
+	err := txn.Commit(context.Background())
+	c.Assert(err, IsNil)
+	// Check region split after test.
+	checkKeyRegion(bo, startKey, endKey, Not(Equals))
+}