diff --git a/ddl/db_integration_test.go b/ddl/db_integration_test.go
index d52ad7f412f95..f06a4b1c19c94 100644
--- a/ddl/db_integration_test.go
+++ b/ddl/db_integration_test.go
@@ -29,6 +29,7 @@ import (
 	_ "github.com/pingcap/tidb/autoid_service"
 	"github.com/pingcap/tidb/config"
 	"github.com/pingcap/tidb/ddl/schematracker"
+	"github.com/pingcap/tidb/ddl/util"
 	"github.com/pingcap/tidb/ddl/util/callback"
 	"github.com/pingcap/tidb/domain"
 	"github.com/pingcap/tidb/errno"
@@ -4418,3 +4419,68 @@ func TestReorganizePartitionWarning(t *testing.T) {
 	tk.MustExec("alter table t reorganize partition p0 into (partition p01 values less than (10), partition p02 values less than (20));")
 	tk.MustQuery("show warnings").Check(testkit.Rows("Warning 1105 The statistics of related partitions will be outdated after reorganizing partitions. Please use 'ANALYZE TABLE' statement if you want to update it now"))
 }
+
+func TestIssue52680(t *testing.T) {
+	store, dom := testkit.CreateMockStoreAndDomain(t)
+	tk := testkit.NewTestKit(t, store)
+	tk.MustExec("use test;")
+	tk.MustExec("create table issue52680 (id bigint primary key auto_increment) auto_id_cache=1;")
+	tk.MustExec("insert into issue52680 values(default),(default);")
+	tk.MustQuery("select * from issue52680").Check(testkit.Rows("1", "2"))
+
+	is := dom.InfoSchema()
+	tbl, err := is.TableByName(model.NewCIStr("test"), model.NewCIStr("issue52680"))
+	ti := tbl.Meta()
+	require.NoError(t, err)
+	dbInfo, ok := is.SchemaByName(model.NewCIStr("test"))
+	require.True(t, ok)
+
+	util.EmulatorGCDisable()
+	defer util.EmulatorGCEnable()
+
+	// For mocktikv, safe point is not initialized, we manually insert it for snapshot to use.
+	safePointName := "tikv_gc_safe_point"
+	safePointValue := "20060102-15:04:05 -0700"
+	safePointComment := "All versions after safe point can be accessed. (DO NOT EDIT)"
+	updateSafePoint := fmt.Sprintf(`INSERT INTO mysql.tidb VALUES ('%[1]s', '%[2]s', '%[3]s')
+	ON DUPLICATE KEY
+	UPDATE variable_value = '%[2]s', comment = '%[3]s'`, safePointName, safePointValue, safePointComment)
+	tk.MustExec(updateSafePoint)
+
+	testSteps := []struct {
+		sql    string
+		expect meta.AutoIDGroup
+	}{
+		{sql: "", expect: meta.AutoIDGroup{RowID: 0, IncrementID: 4000, RandomID: 0}},
+		{sql: "drop table issue52680", expect: meta.AutoIDGroup{RowID: 0, IncrementID: 0, RandomID: 0}},
+		{sql: "recover table issue52680", expect: meta.AutoIDGroup{RowID: 0, IncrementID: 4000, RandomID: 0}},
+	}
+	for _, step := range testSteps {
+		if step.sql != "" {
+			tk.MustExec(step.sql)
+		}
+
+		txn, err := store.Begin()
+		require.NoError(t, err)
+		m := meta.NewMeta(txn)
+		idAcc := m.GetAutoIDAccessors(dbInfo.ID, ti.ID)
+		ids, err := idAcc.Get()
+		require.NoError(t, err)
+		require.Equal(t, ids, step.expect)
+		txn.Rollback()
+	}
+
+	tk.MustQuery("show table issue52680 next_row_id").Check(testkit.Rows(
+		"test issue52680 id 1 _TIDB_ROWID",
+		"test issue52680 id 3 AUTO_INCREMENT",
+	))
+
+	is = dom.InfoSchema()
+	tbl1, err := is.TableByName(model.NewCIStr("test"), model.NewCIStr("issue52680"))
+	require.NoError(t, err)
+	ti1 := tbl1.Meta()
+	require.Equal(t, ti1.ID, ti.ID)
+
+	tk.MustExec("insert into issue52680 values(default);")
+	tk.MustQuery("select * from issue52680").Check(testkit.Rows("1", "2", "3"))
+}
diff --git a/ddl/table.go b/ddl/table.go
index 191d102f60dd8..0ca8ab6c4a7c5 100644
--- a/ddl/table.go
+++ b/ddl/table.go
@@ -533,7 +533,7 @@ func (w *worker) recoverTable(t *meta.Meta, job *model.Job, recoverInfo *Recover
 	tableInfo := recoverInfo.TableInfo.Clone()
 	tableInfo.State = model.StatePublic
 	tableInfo.UpdateTS = t.StartTS
-	err = t.CreateTableAndSetAutoID(recoverInfo.SchemaID, tableInfo, recoverInfo.AutoIDs.RowID, recoverInfo.AutoIDs.RandomID)
+	err = t.CreateTableAndSetAutoID(recoverInfo.SchemaID, tableInfo, recoverInfo.AutoIDs)
 	if err != nil {
 		return ver, errors.Trace(err)
 	}
diff --git a/meta/meta.go b/meta/meta.go
index 02e99d0f106d2..b5fde687bb21d 100644
--- a/meta/meta.go
+++ b/meta/meta.go
@@ -761,17 +761,23 @@ func (m *Meta) GetMetadataLock() (enable bool, isNull bool, err error) {
 
 // CreateTableAndSetAutoID creates a table with tableInfo in database,
 // and rebases the table autoID.
-func (m *Meta) CreateTableAndSetAutoID(dbID int64, tableInfo *model.TableInfo, autoIncID, autoRandID int64) error {
+func (m *Meta) CreateTableAndSetAutoID(dbID int64, tableInfo *model.TableInfo, autoIDs AutoIDGroup) error {
 	err := m.CreateTableOrView(dbID, tableInfo)
 	if err != nil {
 		return errors.Trace(err)
 	}
-	_, err = m.txn.HInc(m.dbKey(dbID), m.autoTableIDKey(tableInfo.ID), autoIncID)
+	_, err = m.txn.HInc(m.dbKey(dbID), m.autoTableIDKey(tableInfo.ID), autoIDs.RowID)
 	if err != nil {
 		return errors.Trace(err)
 	}
 	if tableInfo.AutoRandomBits > 0 {
-		_, err = m.txn.HInc(m.dbKey(dbID), m.autoRandomTableIDKey(tableInfo.ID), autoRandID)
+		_, err = m.txn.HInc(m.dbKey(dbID), m.autoRandomTableIDKey(tableInfo.ID), autoIDs.RandomID)
+		if err != nil {
+			return errors.Trace(err)
+		}
+	}
+	if tableInfo.SepAutoInc() && tableInfo.GetAutoIncrementColInfo() != nil {
+		_, err = m.txn.HInc(m.dbKey(dbID), m.autoIncrementIDKey(tableInfo.ID), autoIDs.IncrementID)
 		if err != nil {
 			return errors.Trace(err)
 		}
diff --git a/meta/meta_test.go b/meta/meta_test.go
index 747d64073064c..1db032fe87fdb 100644
--- a/meta/meta_test.go
+++ b/meta/meta_test.go
@@ -394,7 +394,7 @@ func TestMeta(t *testing.T) {
 		ID:   3,
 		Name: model.NewCIStr("tbl3"),
 	}
-	err = m.CreateTableAndSetAutoID(1, tbInfo3, 123, 0)
+	err = m.CreateTableAndSetAutoID(1, tbInfo3, meta.AutoIDGroup{RowID: 123, IncrementID: 0})
 	require.NoError(t, err)
 	id, err := m.GetAutoIDAccessors(1, tbInfo3.ID).RowID().Get()
 	require.NoError(t, err)