Gene page: Protein features
-Gene pages for protein-coding genes have a section describing protein features. Also see the Modifications documentation.
+Gene page: Protein domains and properties
+Gene pages for protein-coding genes have a section describing protein domains and properties. Also see the Modifications documentation.
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@@ -1,4 +1,20 @@
Microtubule competition and cell growth recenter the nucleus after anaphase in fission yeast.
+ + + +Originally published in Mol Biol Cell.
+ +Actin-Microtubule Crosstalk Imparts Stiffness to the Contractile Ring in Fission Yeast.
+ + + +Originally published in Cells.
+ +Tfs1, transcription elongation factor TFIIS, has an impact on chromosome segregation affected by pka1 deletion in Schizosaccharomyces pombe.
@@ -6,7 +22,7 @@Originally published in Curr Genet.
RNA polymerase II CTD interactome with 3’ processing and termination factors in fission yeast and its impact on phosphate homeostasis.
@@ -14,7 +30,7 @@Originally published in Proc Natl Acad Sci U S A.
Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination.
@@ -22,7 +38,7 @@Originally published in RNA.
Fission yeast Dis1 is an unconventional TOG/XMAP215 that induces microtubule catastrophe to drive chromosome pulling.
@@ -30,7 +46,7 @@Originally published in Commun Biol.
Inorganic polyphosphate abets silencing of a sub-telomeric gene cluster in fission yeast.
@@ -38,7 +54,7 @@Originally published in MicroPubl Biol.
Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast.
@@ -46,7 +62,7 @@Originally published in Elife.
A scaffold lncRNA shapes the mitosis to meiosis switch.
@@ -54,7 +70,7 @@Originally published in Nat Commun.
The SAGA histone acetyltransferase module targets SMC5/6 to specific genes.
@@ -62,7 +78,7 @@Originally published in Epigenetics Chromatin.
Protein S-palmitoylation regulates different stages of meiosis in Schizosaccharomyces pombe.
@@ -70,7 +86,7 @@Originally published in Life Science Alliance.
Microtubule-mitochondrial attachment facilitates cell division symmetry and mitochondrial partitioning in fission yeast.
@@ -78,7 +94,7 @@Originally published in Journal of cell Science.
Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast.
@@ -86,11 +102,11 @@Originally published in Bioscience, Biotechnology, and Biochemistry.
Contractile ring structure at nanoscale resolution. Image from eLife 2017;6:e28865, used under CC-BY license terms.
Molecular model of fission yeast centrosome assembly determined by superresolution imaging.
@@ -98,7 +114,7 @@Originally published in Journal of Cell Biology.
Structural Basis for Shelterin Bridge Assembly.
@@ -106,7 +122,7 @@Originally published in Molecular Cell.
Study shows second ssDNA capture by the SMC complex during establishment of sister chromatid cohesion.
@@ -114,7 +130,7 @@Originally published in Cell.
Model illustrating collaborative inward force generation by kinesin-14s.
@@ -122,7 +138,7 @@Originally published in Journal of Cell Science.
CAGE-defined Transcription Start Sites across 5 different conditions.
@@ -130,7 +146,7 @@Originally published in the Nucleic Acids Research.
The ancient claudin Dni2 facilitates cell fusion at the shmoo tip.
@@ -138,7 +154,7 @@Originally published in Cellular and Molecular Life Sciences.
Graph-based visualization of Hi-C datasets.
@@ -146,7 +162,7 @@Originally published in BMC Research Notes.
A unified model for cell size control.
@@ -154,7 +170,7 @@Originally published in Journal of Cell Biology. Image from a Commentary by Gerganova and Martin.
A Cdk9-PP1 switch for RNA polymerase II elongation-termination.
@@ -162,7 +178,7 @@Originally published in Nature.
Quantitative phosphoproteomics reveals the signaling dynamics of cell-cycle kinases; ~10K phosphorylation sites now in PomBase.
@@ -170,7 +186,7 @@Originally published in Cell Reports.
Sharpening the anaphase switch.
@@ -178,7 +194,7 @@Originally published in Cell Reports.
Microtubule depolymerization in scd1Δ cells leads to PORTLI growth.
@@ -186,7 +202,7 @@Originally published in the Journal of Cell Science.
Essential genes for quiescence to cell cycle switching.
@@ -194,7 +210,7 @@Originally published in Science Advances.
Genome-wide phenotypic analysis of chromate toxicity.
@@ -202,7 +218,7 @@Originally published in PLoS Genetics.
wtf genes in poison–antidote meiotic drive and its suppression.
@@ -210,7 +226,7 @@Originally published in PLoS Genetics.
RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not.
@@ -218,7 +234,7 @@Originally published in eLife. Image from eLife 2019;8:e40670, used under CC-BY license terms.
Cryo-EM structure of kinesin-5-microtubule complex reveals a distinct binding footprint and mechanism of drug resistance.
@@ -226,7 +242,7 @@Originally published in JMB.
Centromere DNA destabilizes H3 nucleosomes to promote CENP-A deposition during the cell cycle.
@@ -234,7 +250,7 @@Originally published in Current Biology.
DNA topoisomerase II phosphorylation in fission yeast reveals anticancer mechanism.
@@ -242,7 +258,7 @@Originally published in Journal of Biological Chemistry.
Zinc transporters belonging to the Cation Diffusion Facilitator (CDF) family have complementary roles in transporting zinc out of the cytosol.
@@ -250,7 +266,7 @@Originally published in PLoS Genetics.
Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
@@ -258,7 +274,7 @@Originally published in Nature Communications.
Swi5-Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation.
@@ -266,7 +282,7 @@Originally published in PNAS.
Specific primary septum detection reveals septum and cleavage furrow ingression during early anaphase independent of mitosis completion.
@@ -274,7 +290,7 @@Originally published in PLoS Genetics.
Paxillin-mediated recruitment of calcineurin to the contractile ring is required for cytokinesis.
@@ -282,127 +298,127 @@Originally published in Cell Reports.
Taf12 phosphorylation inhibits sexual differentiation downstream of TORC2.
Originally published in EMBO reports.
Unexpected insertion of carrier DNA during CRISPR-Cas9, and “unknowns” remain “unknown”
Originally published in BMC Research Notes.
NDR Kinase Sid2 Drives Anillin-like Mid1 from the Membrane to Promote Cytokinesis.
Originally published in Current Biology.
Set7, a histone methyltransferase for the uncharted histone H3-37 mark.
Originally published in Structure.
Fission yeast contains separate CC- and A-adding tRNA nucleotidyltransferases.
Originally published in Biochemical and Biophysical Research Communications.
Distinct roles of myosin-II isoforms in cytokinesis under normal and stressed conditions.
Originally published in iScience.
Previously uncharacterized protein, Ync13, has a role during late stages of cytokinesis.
Originally published in Molecular Biology of the Cell.
Simple procedure for the generation of temperature-sensitive mutations with error-prone PCR.
Originally published in Bioscience, Biotechnology, and Biochemistry.
Isolation of single amino acid t-s mutants in condensin hinge domain.
Originally published in G3: Genes, Genomes, Genetics.
Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin.
Originally published in PNAS.
Sequencing of suppressor DNA mixtures identifies pathways that compensate for chromosome segregation defects.
Originally published in G3: Genes, Genomes, Genetics.
A. Prevailing ring model vs. B. hold and release model; Suppressor mutation analysis combined with 3D modeling proposes a different mechanism for cohesin.
Originally published in PNAS.
Fission yeast TRP channel Pkd2p localizes to the cleavage furrow during cytokinesis.
Originally published in Molecular Biology of the Cell.
The J-domain co-chaperone Rsp1 interacts with Mto1 to organize non-centrosomal microtubule assembly.
Originally published in Molecular Biology of the Cell.
The PCNA unloader Elg1 promotes recombination at collapsed replication forks.
Originally published in eLife. Image from eLife 2019;8:e47277, used under CC-BY license terms.
MAPs and Microtubule Dynamics Balance with the Cut7/Kinesin-5 Motor for Mitotic Spindle Assembly.
Originally published in G3: Genes, Genomes, Genetics.
Nuclear “blebbing” in Lem2 mutants from “Nuclear membrane protein Lem2 regulates nuclear size through membrane flow”.
Originally published in Nature Communications.
Coordinated Roles of the Putative Ceramide-Conjugation Protein, Cwh43, and a Mn 2+ -Transporting, P-Type ATPase, Pmr1.
Originally published in G3: Genes, Genomes, Genetics.
Epe1 associates with the SAGA complex to promote transcription of repeats for heterochromatin assembly.
Originally published in Genes & Development.
The F-BAR Domain of Rga7 Relies on a Cooperative Mechanism of Membrane Binding with Rng10.
Originally published in Cell Reports.
The fitness landscape of the fission yeast genome.
@@ -414,337 +430,337 @@A Cdc42 GEF, Gef1, organizes F-BAR Cdc15 along the actomyosin ring.
Originally published in Journal of Cell Science.
Abrogation of glucosidase I-mediated glycoprotein deglucosylation results in a sick phenotype in fission yeasts: Model for the human MOGS-CDG disorder.
Originally published in Journal of Biological Chemistry.
Factors affecting template switch recombination associated with restarted DNA replication.
Originally published in eLife. Image from eLife 2019;8:e41697, used under CC-BY license terms.
Asc1 stabilizes the interaction between eIF3a and Rps0A/uS2 for protein synthesis.
Originally published in Molecular and Cellular Biology.
H3K14 ubiquitylation promotes H3K9 methylation for heterochromatin assembly.
Originally published in EMBO reports.
Lem2 is retained at the nuclear envelope through its interaction with Bqt4 in fission yeast. LEM domain directly binds to DNA.
Originally published in Genes Cells.
A new TF binding site (Loz1 response element) for zinc repression.
Originally published in Molecular Microbiology.
Kinetochore-mediated outward force promotes spindle pole separation.
Originally published in Molecular Biology of the Cell.
Capping Protein Insulates Arp2/3-Assembled Actin Patches from Formins.
Originally published in Current Biology.
Microtubules and Alp7-Alp14 (TACC-TOG) reposition meiotic chromosomes.
Originally published in Nature Cell Biology.
F-BAR Cdc15 Promotes Cdc42 Activation During Cytokinesis and Cell Polarization in Schizosaccharomyces pombe.
Originally published in Genetics.
Tel2-Tti1-Tti2 complex destabilization eliminates Rad3-ATR kinase signaling in the DNA replication checkpoint and leads to telomere shortening.
Originally published in Molecular and Cell Biology.
CLASP promotes microtubule bundling in metaphase spindle independently of Ase1.
Originally published in Biology Open.
The Bub1-TPR domain interacts directly with Mad3 to generate robust spindle checkpoint arrest.
Originally published in Current Biology.
Effects of the microtubule nucleator Mto1 on chromosome movement, DNA repair and sister chromatid cohesion.
Originally published in Molecular Biology of the Cell.
Association of mitochondria with microtubules inhibits mitochondrial fission.
Originally published in Journal of Biological Chemistry.
A highly modular toolbox to introduce heterologous sequences and includes antibiotic resistance markers, promoters, fluorescent tags, and terminators.
Originally published in Journal of Cell Science.
Role for cleavage and polyadenylation factor (CPF) in RNAi-independent heterochromatin domain assembly.
Originally published in Cell Reports.
Gcn5-mediated acetylation at MBF-regulated promoters induces the G1/S transcriptional wave.
Originally published in Nucleic Acids Research.
Mkt1 is required for RNAi-mediated silencing and establishment of heterochromatin in fission yeast.
Originally published in Nucleic Acids Research.
Physical basis for long-distance communication along meiotic chromosomes.
Originally published in PNAS.
A novel interplay between GEFs orchestrates Cdc42 activity during cell polarity and cytokinesis in fission yeast.
Originally published in Journal of Cell Science.
Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Originally published in Cell Reports.
Structures of the Mitochondrial CDP-DAG Synthase Tam41 Suggest a Potential Lipid Substrate Pathway from Membrane to the Active Site.
Originally published in Structure.
Atg38-Atg8 Interaction in Fission Yeast Establishes a Positive Feedback Loop to Promote Autophagy
Originally published in Autophagy.
Plasma Membrane Furrows Control Plasticity of ER-PM Contacts.
Originally published in Cell Reports.
Chromatin remodeler Fft3 plays a dual role at blocked DNA replication forks.
Originally published in Life Science Alliance.
Cortical tethering of mitochondria by the anchor protein Mcp5 enables uniparental inheritance.
Originally published in Journal of Cell Biology.
Casein kinase 2 regulates telomere protein complex formation through Rap1 phosphorylation.
Originally published in Nucleic Acids Research.
Checkpoint Regulation of Nuclear Tos4 Defines S Phase Arrest in Fission Yeast.
Originally published in G3: Genes, Genomes, Genetics.
The NuA4 acetyltransferase and histone H4 acetylation promote replication recovery after topoisomerase I-poisoning.
Originally published in Epigenetics & Chromatin.
Dramatically diverse ’Schizosaccharomyces pombe wtf* meiotic drivers all display high gamete-killing efficiency.
Originally published in PLoS Genetics.
Genetic investigation of formaldehyde-induced DNA damage response in Schizosaccharomyces pombe.
Originally published in Current Genetics.
Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan.
Originally published in Aging Cell.
Cooperative interactions facilitate stimulation of Rad51 by the Swi5-Sfr1 auxiliary factor complex.
Originally published in eLife. Image: left panel from eLife 2020;9:52566, used under CC-BY license terms; right panel B. Argunhan pers. comm.
Chaperone-Facilitated Aggregation of Thermo-Sensitive Proteins Shields Them from Degradation during Heat Stress.
Originally published in Cell Reports.
Ctp1 protein-DNA filaments promote DNA bridging and DNA double-strand break repair.
Originally published in Journal of Biological Chemistry.
Chromosome-associated RNA-protein complexes promote pairing of homologous chromosomes during meiosis.
Originally published in Nature Communications.
Mutations in a single signaling pathway allow cell growth in heavy water.
Image reprinted with permission from ACS Synthetic Biology 2020 9 (4), 733-748. Copyright 2020 American Chemical Society.
Pyruvate kinase variant of fission yeast tunes carbon metabolism, cell regulation, growth and stress resistance.
Originally published in Molecular Systems Biology.
Conserved roles of chromatin remodellers in cohesin loading onto chromatin.
Originally published in Current Genetics.
Different Functionality of Cdc20 Binding Sites within the Mitotic Checkpoint Complex.
Originally published in Curr.Biol.
Active replication checkpoint drives genome instability in fission yeast mcm4 mutant.
Originally published in Molecular and Cellular Biology.
Spt5 phosphorylation and the Rtf1 Plus3 domain promote Rtf1 function through distinct mechanisms.
Originally published in Molecular and Cellular Biology.
Glucose limitation and pka1 deletion rescue aberrant mitotic spindle formation induced by Mal3 overexpression in Schizosaccharomyces pombe.
Originally published in Bioscience, Biotechnology, and Biochemistry.
Two Auxiliary Factors Promote Dmc1-driven DNA Strand Exchange via Stepwise Mechanisms .
Originally published in PNAS.
DYRK kinase Pom1 drives F-BAR protein Cdc15 from the membrane to promote medial division.
Originally published in Molecular Biology of the Cell.
Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylation.
Originally published in Genes & Development.
DNA replication machinery prevents Rad52-dependent single-strand annealing that leads to gross chromosomal rearrangements at centromeres.
Originally published in Communications Biology.
Nuclear Envelope Attachment of Telomeres Limits TERRA and Telomeric Rearrangements in Quiescent Fission Yeast Cells.
Originally published in Nucleic Acids Research.
Cdk9 and H2Bub1 signal to Clr6-CII/Rpd3S to suppress aberrant antisense transcription.
Originally published in Nucleic Acids Research.
The phosphatase inhibitor Sds23 regulates cell division symmetry in fission yeast.
Originally published in Molecular Biology of the Cell.
A role of the Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6.
Originally published in Scientific Reports.
Sterol biosensor reveals LAM-family Ltc1-dependent sterol flow to endosomes upon Arp2/3 inhibition.
Originally published in Journal of Cell Biology.
A UPR-Induced Soluble ER-Phagy Receptor Acts with VAPs to Confer ER Stress Resistance.
Originally published in Molecular Cell.
CRL4Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation.
@@ -752,859 +768,859 @@Originally published in PLoS Genetics.
Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.
Originally published in Cell Reports.
Closed mitosis requires local disassembly of the nuclear envelope.
Originally published in Nature.
Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant.
Originally published in iScience.
Atypical meiosis can be adaptive in outcrossed Schizosaccharomyces pombe due to wtf meiotic drivers.
Originally published in eLife. Image from eLife 2020;9:e57936, used under CC-BY license terms.
Time-lapse single-cell transcriptomics reveals modulation of histone H3 for dormancy breaking in fission yeast.
Originally published in Nature Communications.
Condensin locates at transcriptional termination sites in mitosis, possibly releasing mitotic transcripts.
Originally published in Open Biology.
Atg1 kinase in fission yeast is activated by Atg11-mediated dimerization and cis-autophosphorylation.
Originally published in eLife. Image from eLife 2020;9:e58073, used under CC-BY license terms.
The Catalytic-Dependent and -Independent Roles of Lsd1 and Lsd2 Lysine Demethylases in Heterochromatin Formation in Schizosaccharomyces pombe.
Originally published in Cells.
Removal of centrosomal PP1 by NIMA kinase unlocks the MPF feedback loop to promote mitotic commitment in S. pombe.
Originally published in Current Biology.
Requirement of PP2A-B56 Par1 for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/C Ste9 during Pre-Start G1 in S. pombe.
Originally published in iScience.
A Redox-Sensitive Thiol in Wis1 Modulates the Fission Yeast Mitogen-Activated Protein Kinase Response to H2O2 and Is the Target of a Small Molecule.
Originally published in Molecular and Cellular Biology.
RNA-Binding Protein Rnc1 Regulates Cell Length at Division and Acute Stress Response in Fission Yeast through Negative Feedback Modulation of the Stress-Activated Mitogen-Activated Protein Kinase Pathway.
Originally published in mBio.
Golgi localization of glycosyltransferases requires Gpp74p in Schizosaccharomyces pombe.
Originally published in Applied Microbiology and Biotechnology.
Stress-activated MAPK signalling controls fission yeast actomyosin ring integrity by modulating formin For3 levels.
Originally published in eLife. Image from eLife 2020;9:e57951, used under CC-BY license terms.
The CDK Pef1 and PP4 (Ppe2) oppose each other for regulating cohesin binding to chromosomes.
Originally published in eLife. Image from eLife 2020;9:e50556, used under CC-BY license terms.
A review of genes involved in extension of chronological lifespan, and the identification of 4 new CLS genes.
Originally published in Molecular Microbiology.
Fission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage.
Originally published in Genome Biology.
Elongation/Termination Factor Exchange Mediated by PP1 Phosphatase Orchestrates Transcription Termination.
Originally published in Cell Reports.
Molecular Mechanism for the Actin-Binding Domain of α-Actinin Ain1 Elucidated by Molecular Dynamics Simulations and Mutagenesis Experiments.
Originally published in The Journal of Physical Chemistry.
The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal.
Originally published in Nature Communications.
Selective Nuclear Pore Complex Removal Drives Nuclear Envelope Division in Fission Yeast.
Originally published in Current Biology.
High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Originally published in International Journal of Molecular Sciences.
Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast.
Originally published in EMBO Reports.
Systematic Target Screening Revealed That Tif302 Could Be an Off-Target of the Antifungal Terbinafine in Fission Yeast.
Originally published in Biomolecules & Therapeutics.
Serine catabolism produces ROS, sensitizes cells to actin dysfunction, and suppresses cell growth in fission yeast.
Originally published in The Journal of Antibiotics.
Phosphoproteomics Reveals Novel Targets and Phosphoprotein Networks in Cell Cycle Mediated by Dsk1.
Originally published in Journal of Proteome Research.
Opposite Surfaces of the Cdc15 F-BAR Domain Create a Membrane Platform That Coordinates Cytoskeletal and Signaling Components for Cytokinesis.
Originally published in Cell Reports.
Atg43 tethers isolation membranes to mitochondria to promote starvation-induced mitophagy in fission yeast.
Originally published in eLife. Image from eLife 2020;9:e61245, used under CC-BY license terms.
The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation.
Originally published in PLoS Genetics.
The Fission Yeast RNA-Binding Protein Meu5 Is Involved in Outer Forespore Membrane Breakdown during Spore Formation.
Originally published in Journal of Fungi.
Formation of S. pombe Erh1 homodimer mediates gametogenic gene silencing and meiosis progression.
Originally published in Scientific Reports.
Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences.
Originally published in PLoS Genetics.
The Hsp40 Mas5 Connects Protein Quality Control and the General Stress Response through the Thermo-sensitive Pyp1.
Originally published in iScience.
The fission yeast Pin1 peptidyl-prolyl isomerase promotes dissociation of Sty1 MAPK from RNA polymerase II and recruits Ssu72 phosphatase to facilitate oxidative stress induced transcription.
Originally published in Nucleic Acids Research.
Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT..
Originally published in Journal of Proteomics.
Comparison of loop extrusion and diffusion capture as mitotic chromosome formation pathways in fission yeast.
Originally published in Nucleic Acids Research.
Escape from mitotic catastrophe by actin-dependent nuclear displacement in fission yeast..
Originally published in iScience.
RNA interference is essential for cellular quiescence.
Originally published in Science.
Integrity of a heterochromatic domain ensured by its boundary elements.
Originally published in PNAS.
Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast..
Originally published in Nucleic Acids Research.
Abo1 is required for the H3K9me2 to H3K9me3 transition in heterochromatin.
Originally published in Scientific Reports.
Repression of a large number of genes requires interplay between homologous recombination and HIRA.
Originally published in Nucleic Acids Research.
The Hydrophobic Patch Directs Cyclin B to Centrosomes to Promote Global CDK Phosphorylation at Mitosis.
Originally published in Current Biology.
Replication dynamics of recombination-dependent replication forks.
Originally published in Nature Communications.
TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.
Originally published in Nature Cell Biology.
Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex.
Originally published in Epigenetics & Chromatin.
Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction..
Originally published in Journal of Cell Biology.
Size-Dependent Increase in RNA Polymerase II Initiation Rates Mediates Gene Expression Scaling with Cell Size.
Originally published in Current Biology.
Schizosaccharomyces pombe KAT5 contributes to resection and repair of a DNA double strand break.
Originally published in Genetics.
Epigenetic gene silencing by heterochromatin primes fungal resistance.
Originally published in Nature.
Identification and structural analysis of the Schizosaccharomyces pombe SMN complex.
Originally published in Nucleic Acids Research.
The Role of Non-Catalytic Domains of Hrp3 in Nucleosome Remodeling.
Originally published in International Journal of Molecular Sciences.
Analysis of the SNARE Stx8 recycling reveals that the retromer-sorting motif has undergone evolutionary divergence.
Originally published in PLoS Genetics.
TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast.
Originally published in PLoS Genetics.
Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex.
Originally published in Nature Communications.
Multiple nutritional phenotypes of fission yeast mutants defective in genes encoding essential mitochondrial proteins.
Originally published in Open Biology.
Acute Heat Stress Leads to Reversible Aggregation of Nuclear Proteins into Nucleolar Rings in Fission Yeast.
Originally published in Cell Reports.
RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes.
Originally published in Life Science Alliance.
Meikin synergizes with shugoshin to protect cohesin Rec8 during meiosis I.
Originally published in Genes & Development.
The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death.
Originally published in eLife. Image from eLife 2020;9:e55694, used under CC-BY license terms.
Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Originally published in Scientific Reports.
Dri1 mediates heterochromatin assembly via RNAi and histone deacetylation.
Originally published in Genetics.
Deletion of the non-essential Rpb9 subunit of RNA polymerase II results in pleiotropic phenotypes in Schizosaccharomyces pombe.
Originally published in Biochimica et Biophysica Acta.
Substrate specificities of α1,2- and α1,3-galactosyltransferases and characterization of Gmh1p and Otg1p in Schizosaccharomyces pombe.
Originally published in Glycobiology.
Increased expression of Polδ does not alter the canonical replication program in vivo.
Originally published in Wellcome Open Research.
Dual Impact of a Benzimidazole Resistant β-Tubulin on Microtubule Behavior in Fission Yeast.
Originally published in Cells.
The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin.
Originally published in Cell Reports.
Magnesium depletion extends fission yeast lifespan via general amino acid control activation.
Originally published in MicrobiologyOpen.
The Putative RNA-Binding Protein Dri1 Promotes the Loading of Kinesin-14/Klp2 to the Mitotic Spindle and Is Sequestered into Heat-Induced Protein Aggregates in Fission Yeast.
Originally published in International Journal of Molecular Sciences.
Linear elements are stable structures along the chromosome axis in fission yeast meiosis.
Originally published in Chromosoma.
Identification of sur2 mutation affecting the lifespan of fission yeast.
Originally published in FEMS Microbiology Letters.
A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity.
Originally published in PNAS.
Expression of Mug14 is regulated by the transcription factor Rst2 through the cAMP-dependent protein kinase pathway in Schizosaccharomyces pombe.
Originally published in Current Genetics.
The intra-S phase checkpoint directly regulates replication elongation to preserve the integrity of stalled replisomes.
Originally published in PNAS.
TORC2 inhibition of α-arrestin Aly3 mediates cell surface persistence of S. pombe Ght5 glucose transporter in low glucose.
Originally published in Journal of Cell Science.
Single-Molecule Imaging Reveals the Mechanism Underlying Histone Loading of Schizosaccharomyces pombe AAA+ ATPase Abo1. (Image from Cho et al. 2019).
Originally published in Molecules and Cells.
Spatial sequestration of misfolded proteins as an active chaperone-mediated process during heat stress.
Originally published in Current Genetics.
Regulation of inorganic polyphosphate is required for proper vacuolar proteolysis in fission yeast.
Originally published in Journal of Biological Chemistry.
Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase.
Originally published in eLife. Image from eLife 2021;10:e60969, used under CC-BY license terms.
Mapping and Analysis of Swi5 and Sfr1 Phosphorylation Sites.
Originally published in Genes.
Molecular and structural mechanisms of ZZ domain-mediated cargo selection by Nbr1.
Originally published in The EMBO Journal.
Molecular organization of cytokinesis node predicts the constriction rate of the contractile ring..
Originally published in Journal of Cell Biology.
Phosphorylation in the intrinsically disordered region of F-BAR protein Imp2 regulates its contractile ring recruitment.
Originally published in Journal of Cell Science.
Identification of Nrl1 Domains Responsible for Interactions with RNA-Processing Factors and Regulation of Nrl1 Function by Phosphorylation.
Originally published in International Journal of Molecular Sciences.
The INO80 Complex Regulates Epigenetic Inheritance of Heterochromatin.
Originally published in Cell Reports.
The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.
Originally published in Nucleic Acids Research.
Fission yeast Rad8/HLTF facilitates Rad52-dependent chromosomal rearrangements through PCNA lysine 107 ubiquitination.
Originally published in PLoS Genetics.
Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.
Originally published in PLoS Genetics.
Identification of ksg1 mutation showing long-lived phenotype in fission yeast.
Originally published in Genes to Cells.
Fission yeast TOR complex 1 phosphorylates Psk1 through evolutionarily conserved interaction mediated by the TOS motif.
Originally published in Journal of Cell Science.
Loss of kinesin-8 improves the robustness of the self-assembled spindle in Schizosaccharomyces pombe.
Originally published in Journal of Cell Science.
Visual detection of binary, ternary and quaternary protein interactions in fission yeast using a Pil1 co-tethering assay.
Originally published in Journal of Cell Science.
The TOR-dependent phosphoproteome and regulation of cellular protein synthesis..
Originally published in EMBO Journal.
Co-transcriptional RNA cleavage by Drosha homolog Pac1 triggers transcription termination in fission yeast.
SUV39 SET domains mediate crosstalk of heterochromatic histone marks.
Originally published in eLife. Image from eLife 2021;10:e62682, used under CC-BY license terms.
Quality-Control Mechanism for Telomerase RNA Folding in the Cell.
Originally published in Cell Reports.
Counting actin in contractile rings reveals novel contributions of cofilin and type II myosins to fission yeast cytokinesis..
Originally published in Mol Biol Cell.
The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states.
Originally published in Cell Rep.
Transcription-wide mapping of dihydrouridine reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation.
Originally published in Mol Cell..
Activation of meiotic recombination by nuclear import of the DNA break hotspot-determining complex.
Originally published in J Cell Sci.
Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1.
Originally published in PNAS.
Structure of Fission Yeast Transcription Factor Pho7 Bound to pho1 Promoter DNA and Effect of Pho7 Mutations on DNA Binding and Phosphate Homeostasis.
Originally published in Mol. Cell. Biol..
The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.
Originally published in iScience.
The Ceramide Synthase Subunit Lac1 Regulates Cell Growth and Size in Fission Yeast.
Originally published in Int J Mol Sci.
R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements.
Originally published in PLoS Genet.
Size-Dependent Expression of the Mitotic Activator Cdc25 Suggests a Mechanism of Size Control in Fission Yeast.
Originally published in Curr. Biol..
A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Originally published in Open Biol.
TOR complex 2 contributes to regulation of gene expression via inhibiting Gcn5 recruitment to subtelomeric and DNA replication stress genes.
Originally published in PLoS Genet.
Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4.
Originally published in Nat Commun.
Involvement of Smi1 in cell wall integrity and glucan synthase Bgs4 localization during fission yeast cytokinesis..
Originally published in Mol Biol Cell .
Canavanine resistance mutation can1-1 in Schizosaccharomyces pombe is a missense mutation in the ubiquitin ligase adaptor gene any1.
Originally published in MicroPubl Biol .
Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase.
Originally published in Cell Rep..
Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination.
Originally published in Nucleic Acids Research.
Microtubule rescue at midzone edges promotes overlap stability and prevents spindle collapse during anaphase B.
Originally published in Elife.
The actin assembly requirements of the formin Fus1 to build the fusion focus.
Originally published in Journal of Cell Science.
The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme.
Originally published in Nature Communications.
Mitotic spindle formation in the absence of Polo kinase.
Originally published in PNAS.
Fission stories: using PomBase to understand Schizosaccharomyces pombe biology.
Originally published in Genetics.
Isolated THATCH domain of End4 is unable to bind F-actin independently in the fission yeast Schizosaccharomyces pombe.
Originally published in MicroPubl.
Characterization of canavanine-resistance of cat1 and vhc1 deletions and a dominant any1 mutation in fission yeast.
Originally published in PLoS One.
Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division..
Originally published in JCB.
Coordinated cortical ER remodeling facilitates actomyosin ring assembly.
Originally published in Current Biology.
Detection of surface forces by the cell-wall mechanosensor Wsc1 in yeast.
Originally published in Dev Cell.
Ccp1-Ndc80 switch at the N terminus of CENP-T regulates kinetochore assembly.
Originally published in Proc Natl Acad Sci.
Queuosine salvage in fission yeast by Qng1-mediated hydrolysis to queuine.
Originally published in Biochem Biophys Res Commun.
Queuine links translational control in eukaryotes to a micronutrient from bacteria.
Originally published in Nucleic Acids Res..
Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress.
Originally published in Mol. Cell. Biol..
The Mis6 inner kinetochore subcomplex maintains CENP-A nucleosomes against centromeric non-coding transcription during mitosis.
Originally published in Commun Biol.
Role of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase.
Originally published in Cell.
Inactivation of fission yeast Erh1 de-represses pho1 expression: evidence that Erh1 is a negative regulator of prt lncRNA termination
Originally published in RNA.
Fission yeast Duf89 and Duf8901 are cobalt/nickel-dependent phosphatase-pyrophosphatases that act via a covalent aspartyl-phosphate intermediate.
Originally published in J Biol Chem.
Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3’ processing and transcription termination.
Originally published in Nucleic Acids Research.
Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination.
Originally published in Nucleic Acids Research.
Transcriptional profiling of fission yeast RNA polymerase II CTD mutants.
Originally published in RNA.
Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3’ processing and transcription termination that functions via its effects on CTD phosphatase Ssu72.
Originally published in Nucleic Acids Res..
Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast..
Originally published in mBio.
Interactome of Spliceosome-Associated G-Patch Protein Gpl1 in the Fission Yeast Schizosaccharomyces pombe.
Originally published in Int J Mol Sci.
Recovery from spindle checkpoint-mediated arrest requires a novel Dnt1-dependent APC/C activation mechanism.
Originally published in