diff --git a/src/lock_file/satisfiability.rs b/src/lock_file/satisfiability.rs
index 87e794c87..7100fb69e 100644
--- a/src/lock_file/satisfiability.rs
+++ b/src/lock_file/satisfiability.rs
@@ -258,9 +258,14 @@ pub fn verify_environment_satisfiability(
         let indexes = rattler_lock::PypiIndexes::from(grouped_env.pypi_options());
         match locked_environment.pypi_indexes() {
             None => {
+                // Mismatch when there should be an index but there is not
                 if locked_environment
                     .version()
                     .should_pypi_indexes_be_present()
+                    && locked_environment
+                        .pypi_packages()
+                        .iter()
+                        .any(|(_platform, packages)| !packages.is_empty())
                 {
                     return Err(IndexesMismatch {
                         current: indexes,
diff --git a/tests/add_tests.rs b/tests/add_tests.rs
index 7ced7f6a1..409f4c30e 100644
--- a/tests/add_tests.rs
+++ b/tests/add_tests.rs
@@ -2,6 +2,11 @@ mod common;
 
 use std::str::FromStr;
 
+use crate::common::{
+    builders::{HasDependencyConfig, HasPrefixUpdateConfig},
+    package_database::{Package, PackageDatabase},
+    LockFileExt, PixiControl,
+};
 use pixi::{DependencyType, Project};
 use pixi_consts::consts;
 use pixi_manifest::{pypi::PyPiPackageName, FeaturesExt, SpecType};
@@ -10,12 +15,6 @@ use serial_test::serial;
 use tempfile::TempDir;
 use uv_normalize::ExtraName;
 
-use crate::common::{
-    builders::{HasDependencyConfig, HasPrefixUpdateConfig},
-    package_database::{Package, PackageDatabase},
-    LockFileExt, PixiControl,
-};
-
 /// Test add functionality for different types of packages.
 /// Run, dev, build
 #[tokio::test]
diff --git a/tests/satisfiability/pypi-deps-not-in-lock/pixi.lock b/tests/satisfiability/pypi-deps-not-in-lock/pixi.lock
new file mode 100644
index 000000000..319fa955e
--- /dev/null
+++ b/tests/satisfiability/pypi-deps-not-in-lock/pixi.lock
@@ -0,0 +1,432 @@
+version: 5
+environments:
+  default:
+    channels:
+      - url: https://fast.prefix.dev/conda-forge/
+    packages:
+      linux-64:
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/_libgcc_mutex-0.1-conda_forge.tar.bz2
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/_openmp_mutex-4.5-2_gnu.tar.bz2
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/bzip2-1.0.8-h4bc722e_7.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/ca-certificates-2024.7.4-hbcca054_0.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/ld_impl_linux-64-2.40-hf3520f5_7.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/libexpat-2.6.2-h59595ed_0.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/libffi-3.4.2-h7f98852_5.tar.bz2
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/libgcc-ng-14.1.0-h77fa898_0.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/libgomp-14.1.0-h77fa898_0.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/libnsl-2.0.1-hd590300_0.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/libsqlite-3.46.0-hde9e2c9_0.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/libstdcxx-ng-14.1.0-hc0a3c3a_0.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/libuuid-2.38.1-h0b41bf4_0.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/libxcrypt-4.4.36-hd590300_1.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/libzlib-1.3.1-h4ab18f5_1.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/ncurses-6.5-h59595ed_0.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/openssl-3.3.1-h4bc722e_2.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/python-3.12.5-h2ad013b_0_cpython.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/python_abi-3.12-4_cp312.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/readline-8.2-h8228510_1.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/ruff-0.5.7-py312hbe4c86d_0.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/tk-8.6.13-noxft_h4845f30_101.conda
+        - conda: https://conda.anaconda.org/conda-forge/noarch/tzdata-2024a-h0c530f3_0.conda
+        - conda: https://conda.anaconda.org/conda-forge/linux-64/xz-5.2.6-h166bdaf_0.tar.bz2
+packages:
+  - kind: conda
+    name: _libgcc_mutex
+    version: '0.1'
+    build: conda_forge
+    subdir: linux-64
+    url: https://conda.anaconda.org/conda-forge/linux-64/_libgcc_mutex-0.1-conda_forge.tar.bz2
+    sha256: fe51de6107f9edc7aa4f786a70f4a883943bc9d39b3bb7307c04c41410990726
+    md5: d7c89558ba9fa0495403155b64376d81
+    license: None
+    purls: []
+    size: 2562
+    timestamp: 1578324546067
+  - kind: conda
+    name: _openmp_mutex
+    version: '4.5'
+    build: 2_gnu
+    build_number: 16
+    subdir: linux-64
+    url: https://conda.anaconda.org/conda-forge/linux-64/_openmp_mutex-4.5-2_gnu.tar.bz2
+    sha256: fbe2c5e56a653bebb982eda4876a9178aedfc2b545f25d0ce9c4c0b508253d22
+    md5: 73aaf86a425cc6e73fcf236a5a46396d
+    depends:
+      - _libgcc_mutex 0.1 conda_forge
+      - libgomp >=7.5.0
+    constrains:
+      - openmp_impl 9999
+    license: BSD-3-Clause
+    license_family: BSD
+    purls: []
+    size: 23621
+    timestamp: 1650670423406
+  - kind: conda
+    name: bzip2
+    version: 1.0.8
+    build: h4bc722e_7
+    build_number: 7
+    subdir: linux-64
+    url: https://conda.anaconda.org/conda-forge/linux-64/bzip2-1.0.8-h4bc722e_7.conda
+    sha256: 5ced96500d945fb286c9c838e54fa759aa04a7129c59800f0846b4335cee770d
+    md5: 62ee74e96c5ebb0af99386de58cf9553
+    depends:
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+      - libgcc-ng >=12
+    license: bzip2-1.0.6
+    license_family: BSD
+    purls: []
+    size: 252783
+    timestamp: 1720974456583
+  - kind: conda
+    name: ca-certificates
+    version: 2024.7.4
+    build: hbcca054_0
+    subdir: linux-64
+    url: https://conda.anaconda.org/conda-forge/linux-64/ca-certificates-2024.7.4-hbcca054_0.conda
+    sha256: c1548a3235376f464f9931850b64b02492f379b2f2bb98bc786055329b080446
+    md5: 23ab7665c5f63cfb9f1f6195256daac6
+    license: ISC
+    purls: []
+    size: 154853
+    timestamp: 1720077432978
+  - kind: conda
+    name: ld_impl_linux-64
+    version: '2.40'
+    build: hf3520f5_7
+    build_number: 7
+    subdir: linux-64
+    url: https://conda.anaconda.org/conda-forge/linux-64/ld_impl_linux-64-2.40-hf3520f5_7.conda
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+    md5: b80f2f396ca2c28b8c14c437a4ed1e74
+    constrains:
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+    license: GPL-3.0-only
+    license_family: GPL
+    purls: []
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+    timestamp: 1718625640445
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+    version: 2.6.2
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+    subdir: linux-64
+    url: https://conda.anaconda.org/conda-forge/linux-64/libexpat-2.6.2-h59595ed_0.conda
+    sha256: 331bb7c7c05025343ebd79f86ae612b9e1e74d2687b8f3179faec234f986ce19
+    md5: e7ba12deb7020dd080c6c70e7b6f6a3d
+    depends:
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+    constrains:
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+    license: MIT
+    license_family: MIT
+    purls: []
+    size: 73730
+    timestamp: 1710362120304
+  - kind: conda
+    name: libffi
+    version: 3.4.2
+    build: h7f98852_5
+    build_number: 5
+    subdir: linux-64
+    url: https://conda.anaconda.org/conda-forge/linux-64/libffi-3.4.2-h7f98852_5.tar.bz2
+    sha256: ab6e9856c21709b7b517e940ae7028ae0737546122f83c2aa5d692860c3b149e
+    md5: d645c6d2ac96843a2bfaccd2d62b3ac3
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+    license: MIT
+    license_family: MIT
+    purls: []
+    size: 58292
+    timestamp: 1636488182923
+  - kind: conda
+    name: libgcc-ng
+    version: 14.1.0
+    build: h77fa898_0
+    subdir: linux-64
+    url: https://conda.anaconda.org/conda-forge/linux-64/libgcc-ng-14.1.0-h77fa898_0.conda
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+    depends:
+      - _libgcc_mutex 0.1 conda_forge
+      - _openmp_mutex >=4.5
+    constrains:
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+    license: GPL-3.0-only WITH GCC-exception-3.1
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+    purls: []
+    size: 842109
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+    url: https://conda.anaconda.org/conda-forge/linux-64/xz-5.2.6-h166bdaf_0.tar.bz2
+    sha256: 03a6d28ded42af8a347345f82f3eebdd6807a08526d47899a42d62d319609162
+    md5: 2161070d867d1b1204ea749c8eec4ef0
+    depends:
+      - libgcc-ng >=12
+    license: LGPL-2.1 and GPL-2.0
+    purls: []
+    size: 418368
+    timestamp: 1660346797927
diff --git a/tests/satisfiability/pypi-deps-not-in-lock/pixi.toml b/tests/satisfiability/pypi-deps-not-in-lock/pixi.toml
new file mode 100644
index 000000000..10ae4b6fb
--- /dev/null
+++ b/tests/satisfiability/pypi-deps-not-in-lock/pixi.toml
@@ -0,0 +1,8 @@
+[project]
+channels = ["https://fast.prefix.dev/conda-forge"]
+name = "ruff"
+platforms = ["linux-64"]
+[dependencies]
+ruff = "*"
+[pypi-dependencies]
+ruff = "*"