diff --git a/Include/cpython/abstract.h b/Include/cpython/abstract.h
index 77e2cfa02ed074..161e2cb30fde3e 100644
--- a/Include/cpython/abstract.h
+++ b/Include/cpython/abstract.h
@@ -103,8 +103,8 @@ PyAPI_FUNC(PyObject *) PyObject_VectorcallMethod(
 static inline PyObject *
 PyObject_CallMethodNoArgs(PyObject *self, PyObject *name)
 {
-    return PyObject_VectorcallMethod(name, &self,
-           1 | PY_VECTORCALL_ARGUMENTS_OFFSET, NULL);
+    size_t nargsf = 1 | PY_VECTORCALL_ARGUMENTS_OFFSET;
+    return PyObject_VectorcallMethod(name, &self, nargsf, _Py_NULL);
 }
 
 static inline PyObject *
@@ -113,8 +113,8 @@ PyObject_CallMethodOneArg(PyObject *self, PyObject *name, PyObject *arg)
     PyObject *args[2] = {self, arg};
 
     assert(arg != NULL);
-    return PyObject_VectorcallMethod(name, args,
-           2 | PY_VECTORCALL_ARGUMENTS_OFFSET, NULL);
+    size_t nargsf = 2 | PY_VECTORCALL_ARGUMENTS_OFFSET;
+    return PyObject_VectorcallMethod(name, args, nargsf, _Py_NULL);
 }
 
 PyAPI_FUNC(PyObject *) _PyObject_CallMethod(PyObject *obj,
@@ -144,7 +144,7 @@ _PyObject_VectorcallMethodId(
 {
     PyObject *oname = _PyUnicode_FromId(name); /* borrowed */
     if (!oname) {
-        return NULL;
+        return _Py_NULL;
     }
     return PyObject_VectorcallMethod(oname, args, nargsf, kwnames);
 }
@@ -152,8 +152,8 @@ _PyObject_VectorcallMethodId(
 static inline PyObject *
 _PyObject_CallMethodIdNoArgs(PyObject *self, _Py_Identifier *name)
 {
-    return _PyObject_VectorcallMethodId(name, &self,
-           1 | PY_VECTORCALL_ARGUMENTS_OFFSET, NULL);
+    size_t nargsf = 1 | PY_VECTORCALL_ARGUMENTS_OFFSET;
+    return _PyObject_VectorcallMethodId(name, &self, nargsf, _Py_NULL);
 }
 
 static inline PyObject *
@@ -162,8 +162,8 @@ _PyObject_CallMethodIdOneArg(PyObject *self, _Py_Identifier *name, PyObject *arg
     PyObject *args[2] = {self, arg};
 
     assert(arg != NULL);
-    return _PyObject_VectorcallMethodId(name, args,
-           2 | PY_VECTORCALL_ARGUMENTS_OFFSET, NULL);
+    size_t nargsf = 2 | PY_VECTORCALL_ARGUMENTS_OFFSET;
+    return _PyObject_VectorcallMethodId(name, args, nargsf, _Py_NULL);
 }
 
 PyAPI_FUNC(int) _PyObject_HasLen(PyObject *o);
diff --git a/Include/cpython/unicodeobject.h b/Include/cpython/unicodeobject.h
index 96bfaaf4d2badd..8e182d0fbf7999 100644
--- a/Include/cpython/unicodeobject.h
+++ b/Include/cpython/unicodeobject.h
@@ -642,9 +642,9 @@ static inline Py_ssize_t PyUnicode_GET_SIZE(PyObject *op)
 {
     _Py_COMP_DIAG_PUSH
     _Py_COMP_DIAG_IGNORE_DEPR_DECLS
-    if (_PyASCIIObject_CAST(op)->wstr == NULL) {
+    if (_PyASCIIObject_CAST(op)->wstr == _Py_NULL) {
         (void)PyUnicode_AsUnicode(op);
-        assert(_PyASCIIObject_CAST(op)->wstr != NULL);
+        assert(_PyASCIIObject_CAST(op)->wstr != _Py_NULL);
     }
     return PyUnicode_WSTR_LENGTH(op);
     _Py_COMP_DIAG_POP
@@ -674,7 +674,7 @@ Py_DEPRECATED(3.3)
 static inline Py_UNICODE* PyUnicode_AS_UNICODE(PyObject *op)
 {
     wchar_t *wstr = _PyASCIIObject_CAST(op)->wstr;
-    if (wstr != NULL) {
+    if (wstr != _Py_NULL) {
         return wstr;
     }
 
diff --git a/Include/object.h b/Include/object.h
index f93ecce13b4099..a0dba697569c43 100644
--- a/Include/object.h
+++ b/Include/object.h
@@ -587,7 +587,7 @@ static inline void Py_DECREF(PyObject *op)
 /* Function to use in case the object pointer can be NULL: */
 static inline void Py_XINCREF(PyObject *op)
 {
-    if (op != NULL) {
+    if (op != _Py_NULL) {
         Py_INCREF(op);
     }
 }
@@ -597,7 +597,7 @@ static inline void Py_XINCREF(PyObject *op)
 
 static inline void Py_XDECREF(PyObject *op)
 {
-    if (op != NULL) {
+    if (op != _Py_NULL) {
         Py_DECREF(op);
     }
 }
diff --git a/Include/pyport.h b/Include/pyport.h
index f6270be0ce5c0e..614a2789fb0781 100644
--- a/Include/pyport.h
+++ b/Include/pyport.h
@@ -33,6 +33,14 @@
 #  define _Py_CAST(type, expr) ((type)(expr))
 #endif
 
+// Static inline functions should use _Py_NULL rather than using directly NULL
+// to prevent C++ compiler warnings. In C++, _Py_NULL uses nullptr.
+#ifdef __cplusplus
+#  define _Py_NULL nullptr
+#else
+#  define _Py_NULL NULL
+#endif
+
 
 /* Defines to build Python and its standard library:
  *
diff --git a/Lib/test/_testcppext.cpp b/Lib/test/_testcppext.cpp
index 257843bfc7726d..dc40f0ee9eb1cb 100644
--- a/Lib/test/_testcppext.cpp
+++ b/Lib/test/_testcppext.cpp
@@ -52,7 +52,7 @@ test_api_casts(PyObject *Py_UNUSED(module), PyObject *Py_UNUSED(args))
 
 static PyMethodDef _testcppext_methods[] = {
     {"add", _testcppext_add, METH_VARARGS, _testcppext_add_doc},
-    {"test_api_casts", test_api_casts, METH_NOARGS, NULL},
+    {"test_api_casts", test_api_casts, METH_NOARGS, nullptr},
     {nullptr, nullptr, 0, nullptr}  /* sentinel */
 };
 
@@ -68,7 +68,7 @@ _testcppext_exec(PyObject *module)
 
 static PyModuleDef_Slot _testcppext_slots[] = {
     {Py_mod_exec, reinterpret_cast<void*>(_testcppext_exec)},
-    {0, NULL}
+    {0, nullptr}
 };
 
 
@@ -81,8 +81,8 @@ static struct PyModuleDef _testcppext_module = {
     0,  // m_size
     _testcppext_methods,  // m_methods
     _testcppext_slots,  // m_slots
-    NULL,  // m_traverse
-    NULL,  // m_clear
+    nullptr,  // m_traverse
+    nullptr,  // m_clear
     nullptr,  // m_free
 };
 
diff --git a/Lib/test/test_cppext.py b/Lib/test/test_cppext.py
index fbb79bb8ac3ed1..e056410456630e 100644
--- a/Lib/test/test_cppext.py
+++ b/Lib/test/test_cppext.py
@@ -29,6 +29,8 @@
         '-Werror',
         # Warn on old-style cast (C cast) like: (PyObject*)op
         '-Wold-style-cast',
+        # Warn when using NULL rather than _Py_NULL in static inline functions
+        '-Wzero-as-null-pointer-constant',
     ]
 else:
     # Don't pass any compiler flag to MSVC