diff --git a/stdlib/fcntl.pyi b/stdlib/fcntl.pyi
index 47766357c83f..69863bf580fa 100644
--- a/stdlib/fcntl.pyi
+++ b/stdlib/fcntl.pyi
@@ -6,80 +6,100 @@ from typing_extensions import Literal
 if sys.platform != "win32":
     FASYNC: int
     FD_CLOEXEC: int
-    DN_ACCESS: int
-    DN_ATTRIB: int
-    DN_CREATE: int
-    DN_DELETE: int
-    DN_MODIFY: int
-    DN_MULTISHOT: int
-    DN_RENAME: int
     F_DUPFD: int
     F_DUPFD_CLOEXEC: int
-    F_FULLFSYNC: int
-    F_EXLCK: int
     F_GETFD: int
     F_GETFL: int
-    F_GETLEASE: int
     F_GETLK: int
-    F_GETLK64: int
     F_GETOWN: int
-    F_NOCACHE: int
-    F_GETSIG: int
-    F_NOTIFY: int
     F_RDLCK: int
     F_SETFD: int
     F_SETFL: int
-    F_SETLEASE: int
     F_SETLK: int
-    F_SETLK64: int
     F_SETLKW: int
-    F_SETLKW64: int
-    if sys.version_info >= (3, 9) and sys.platform == "linux":
-        F_OFD_GETLK: int
-        F_OFD_SETLK: int
-        F_OFD_SETLKW: int
     F_SETOWN: int
-    F_SETSIG: int
-    F_SHLCK: int
     F_UNLCK: int
     F_WRLCK: int
-    I_ATMARK: int
-    I_CANPUT: int
-    I_CKBAND: int
-    I_FDINSERT: int
-    I_FIND: int
-    I_FLUSH: int
-    I_FLUSHBAND: int
-    I_GETBAND: int
-    I_GETCLTIME: int
-    I_GETSIG: int
-    I_GRDOPT: int
-    I_GWROPT: int
-    I_LINK: int
-    I_LIST: int
-    I_LOOK: int
-    I_NREAD: int
-    I_PEEK: int
-    I_PLINK: int
-    I_POP: int
-    I_PUNLINK: int
-    I_PUSH: int
-    I_RECVFD: int
-    I_SENDFD: int
-    I_SETCLTIME: int
-    I_SETSIG: int
-    I_SRDOPT: int
-    I_STR: int
-    I_SWROPT: int
-    I_UNLINK: int
+    if sys.platform == "darwin":
+        F_FULLFSYNC: int
+        F_NOCACHE: int
+        if sys.version_info >= (3, 9):
+            F_GETPATH: int
+    if sys.platform == "linux":
+        F_SETLKW64: int
+        F_SETSIG: int
+        F_SHLCK: int
+        F_SETLK64: int
+        F_SETLEASE: int
+        F_GETSIG: int
+        F_NOTIFY: int
+        F_EXLCK: int
+        F_GETLEASE: int
+        F_GETLK64: int
+        if sys.version_info >= (3, 8):
+            F_ADD_SEALS: int
+            F_GET_SEALS: int
+            F_SEAL_GROW: int
+            F_SEAL_SEAL: int
+            F_SEAL_SHRINK: int
+            F_SEAL_WRITE: int
+        if sys.version_info >= (3, 9):
+            F_OFD_GETLK: int
+            F_OFD_SETLK: int
+            F_OFD_SETLKW: int
+        if sys.version_info >= (3, 10):
+            F_GETPIPE_SZ: int
+            F_SETPIPE_SZ: int
+
+        DN_ACCESS: int
+        DN_ATTRIB: int
+        DN_CREATE: int
+        DN_DELETE: int
+        DN_MODIFY: int
+        DN_MULTISHOT: int
+        DN_RENAME: int
+
     LOCK_EX: int
-    LOCK_MAND: int
     LOCK_NB: int
-    LOCK_READ: int
-    LOCK_RW: int
     LOCK_SH: int
     LOCK_UN: int
-    LOCK_WRITE: int
+    if sys.platform == "linux":
+        LOCK_MAND: int
+        LOCK_READ: int
+        LOCK_RW: int
+        LOCK_WRITE: int
+
+    # These are highly problematic, they might be present or not, depends on the specific OS.
+    if sys.platform == "linux":
+        I_ATMARK: int
+        I_CANPUT: int
+        I_CKBAND: int
+        I_FDINSERT: int
+        I_FIND: int
+        I_FLUSH: int
+        I_FLUSHBAND: int
+        I_GETBAND: int
+        I_GETCLTIME: int
+        I_GETSIG: int
+        I_GRDOPT: int
+        I_GWROPT: int
+        I_LINK: int
+        I_LIST: int
+        I_LOOK: int
+        I_NREAD: int
+        I_PEEK: int
+        I_PLINK: int
+        I_POP: int
+        I_PUNLINK: int
+        I_PUSH: int
+        I_RECVFD: int
+        I_SENDFD: int
+        I_SETCLTIME: int
+        I_SETSIG: int
+        I_SRDOPT: int
+        I_STR: int
+        I_SWROPT: int
+        I_UNLINK: int
     @overload
     def fcntl(__fd: FileDescriptorLike, __cmd: int, __arg: int = ...) -> int: ...
     @overload
diff --git a/tests/stubtest_allowlists/darwin.txt b/tests/stubtest_allowlists/darwin.txt
index aa8a3342d1f7..f6d21d2854c2 100644
--- a/tests/stubtest_allowlists/darwin.txt
+++ b/tests/stubtest_allowlists/darwin.txt
@@ -33,7 +33,6 @@ ossaudiodev
 spwd
 
 # Platform differences that cannot be captured by the type system
-fcntl.[A-Z0-9_]+
 os.SCHED_[A-Z_]+
 posix.SCHED_[A-Z_]+
 
diff --git a/tests/stubtest_allowlists/linux.txt b/tests/stubtest_allowlists/linux.txt
index 1052a594f061..429cd4387570 100644
--- a/tests/stubtest_allowlists/linux.txt
+++ b/tests/stubtest_allowlists/linux.txt
@@ -36,7 +36,7 @@ posix.error.characters_written
 resource.error.characters_written
 
 # Platform differences that cannot be captured by the type system
-fcntl.[A-Z0-9_]+
+fcntl.I_[A-Z0-9_]+
 os.SCHED_[A-Z_]+
 posix.SCHED_[A-Z_]+