diff --git a/platform/broadcom/sonic-platform-modules-dell/s6100/scripts/s6100_platform.sh b/platform/broadcom/sonic-platform-modules-dell/s6100/scripts/s6100_platform.sh
index 34dc0daa4ff0..1f65045bd315 100755
--- a/platform/broadcom/sonic-platform-modules-dell/s6100/scripts/s6100_platform.sh
+++ b/platform/broadcom/sonic-platform-modules-dell/s6100/scripts/s6100_platform.sh
@@ -18,6 +18,8 @@ remove_python_api_package() {
 
 
 if [[ "$1" == "init" ]]; then
+
+    pericom="/sys/bus/pci/devices/0000:08:00.0"
     modprobe i2c-dev
     modprobe i2c-mux-pca954x force_deselect_on_exit=1
     modprobe dell_ich
@@ -26,6 +28,10 @@ if [[ "$1" == "init" ]]; then
     modprobe nvram
     systemctl start s6100-reboot-cause.service
 
+    # Disable pericom/xilinx
+    echo 1 > /sys/bus/pci/devices/0000:02:00.0/remove
+    [ -d $pericom ] &&  echo 1 > $pericom/remove
+
     # Disable Watchdog Timer
     if [[ -e /usr/local/bin/platform_watchdog_disable.sh ]]; then
         /usr/local/bin/platform_watchdog_disable.sh