diff --git a/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/NoContentResponseTest.java b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/NoContentResponseTest.java
new file mode 100644
index 0000000000000..3010ea959cee5
--- /dev/null
+++ b/extensions/resteasy-reactive/rest-client-reactive/deployment/src/test/java/io/quarkus/rest/client/reactive/NoContentResponseTest.java
@@ -0,0 +1,65 @@
+package io.quarkus.rest.client.reactive;
+
+import static io.quarkus.rest.client.reactive.RestClientTestUtil.setUrlForClass;
+import static org.junit.jupiter.api.Assertions.assertFalse;
+import static org.junit.jupiter.api.Assertions.assertNull;
+
+import java.io.InputStream;
+
+import jakarta.ws.rs.GET;
+import jakarta.ws.rs.Path;
+import jakarta.ws.rs.Produces;
+import jakarta.ws.rs.core.MediaType;
+import jakarta.ws.rs.core.Response;
+
+import org.eclipse.microprofile.rest.client.inject.RegisterRestClient;
+import org.eclipse.microprofile.rest.client.inject.RestClient;
+import org.jboss.shrinkwrap.api.asset.StringAsset;
+import org.junit.jupiter.api.Test;
+import org.junit.jupiter.api.extension.RegisterExtension;
+
+import io.quarkus.test.QuarkusUnitTest;
+
+public class NoContentResponseTest {
+    @RegisterExtension
+    static final QuarkusUnitTest config = new QuarkusUnitTest()
+            .withApplicationRoot((jar) -> jar
+                    .addClasses(Client.class, Resource.class)
+                    .addAsResource(
+                            new StringAsset(setUrlForClass(Client.class)),
+                            "application.properties"));
+
+    @RestClient
+    Client client;
+
+    @Test
+    public void testGetStreamNoContent() {
+        assertNull(client.getStream());
+    }
+
+    @Test
+    public void testGetResponseNoContent() {
+        Response response = client.getResponse();
+        assertFalse(response.hasEntity());
+        assertNull(response.getEntity());
+    }
+
+    @Path("/test")
+    @RegisterRestClient
+    @Produces(MediaType.TEXT_PLAIN)
+    interface Client {
+        @GET
+        InputStream getStream();
+
+        @GET
+        Response getResponse();
+    }
+
+    @Path("/test")
+    static class Resource {
+        @GET
+        public Response get() {
+            return Response.noContent().build();
+        }
+    }
+}
diff --git a/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/handlers/ClientSetResponseEntityRestHandler.java b/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/handlers/ClientSetResponseEntityRestHandler.java
index 4e4f5745ad57e..546971f68b664 100644
--- a/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/handlers/ClientSetResponseEntityRestHandler.java
+++ b/independent-projects/resteasy-reactive/client/runtime/src/main/java/org/jboss/resteasy/reactive/client/handlers/ClientSetResponseEntityRestHandler.java
@@ -9,6 +9,7 @@
 import jakarta.ws.rs.core.Response;
 import jakarta.ws.rs.core.Response.StatusType;
 
+import org.jboss.resteasy.reactive.RestResponse;
 import org.jboss.resteasy.reactive.client.api.WebClientApplicationException;
 import org.jboss.resteasy.reactive.client.impl.ClientRequestContextImpl;
 import org.jboss.resteasy.reactive.client.impl.ClientResponseContextImpl;
@@ -36,6 +37,12 @@ public void handle(RestClientRequestContext context) throws Exception {
         // so we have to write it, but without filters/interceptors
         if (isAbortedWith(requestContext)) {
             propagateAbortedWithEntityToResponse(context);
+        } else {
+            StatusType effectiveResponseStatus = determineEffectiveResponseStatus(context, requestContext);
+            if ((effectiveResponseStatus.getStatusCode() == RestResponse.Status.NO_CONTENT.getStatusCode())
+                    && !requestContext.hasEntity()) {
+                context.setResponseEntityStream(null);
+            }
         }
     }