diff --git a/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAny1CharValue.cs b/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAny1CharValue.cs
index 762f1872cb64c..de7a8968b2d26 100644
--- a/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAny1CharValue.cs
+++ b/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAny1CharValue.cs
@@ -22,7 +22,7 @@ internal override bool ContainsCore(char value) =>
 
         [MethodImpl(MethodImplOptions.AggressiveInlining)]
         internal override int IndexOfAny(ReadOnlySpan<char> span) =>
-            TShouldUsePacked.Value
+            (PackedSpanHelpers.PackedIndexOfIsSupported && TShouldUsePacked.Value)
                 ? PackedSpanHelpers.IndexOf(ref MemoryMarshal.GetReference(span), _e0, span.Length)
                 : SpanHelpers.NonPackedIndexOfValueType<short, SpanHelpers.DontNegate<short>>(
                     ref Unsafe.As<char, short>(ref MemoryMarshal.GetReference(span)),
@@ -31,7 +31,7 @@ ref Unsafe.As<char, short>(ref MemoryMarshal.GetReference(span)),
 
         [MethodImpl(MethodImplOptions.AggressiveInlining)]
         internal override int IndexOfAnyExcept(ReadOnlySpan<char> span) =>
-            TShouldUsePacked.Value
+            (PackedSpanHelpers.PackedIndexOfIsSupported && TShouldUsePacked.Value)
                 ? PackedSpanHelpers.IndexOfAnyExcept(ref MemoryMarshal.GetReference(span), _e0, span.Length)
                 : SpanHelpers.NonPackedIndexOfValueType<short, SpanHelpers.Negate<short>>(
                     ref Unsafe.As<char, short>(ref MemoryMarshal.GetReference(span)),
diff --git a/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAny2CharValues.cs b/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAny2CharValues.cs
index f649ffc752657..8f5c0c2645623 100644
--- a/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAny2CharValues.cs
+++ b/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAny2CharValues.cs
@@ -22,7 +22,7 @@ internal override bool ContainsCore(char value) =>
 
         [MethodImpl(MethodImplOptions.AggressiveInlining)]
         internal override int IndexOfAny(ReadOnlySpan<char> span) =>
-            TShouldUsePacked.Value
+            (PackedSpanHelpers.PackedIndexOfIsSupported && TShouldUsePacked.Value)
                 ? PackedSpanHelpers.IndexOfAny(ref MemoryMarshal.GetReference(span), _e0, _e1, span.Length)
                 : SpanHelpers.NonPackedIndexOfAnyValueType<short, SpanHelpers.DontNegate<short>>(
                     ref Unsafe.As<char, short>(ref MemoryMarshal.GetReference(span)),
@@ -32,7 +32,7 @@ ref Unsafe.As<char, short>(ref MemoryMarshal.GetReference(span)),
 
         [MethodImpl(MethodImplOptions.AggressiveInlining)]
         internal override int IndexOfAnyExcept(ReadOnlySpan<char> span) =>
-            TShouldUsePacked.Value
+            (PackedSpanHelpers.PackedIndexOfIsSupported && TShouldUsePacked.Value)
                 ? PackedSpanHelpers.IndexOfAnyExcept(ref MemoryMarshal.GetReference(span), _e0, _e1, span.Length)
                 : SpanHelpers.NonPackedIndexOfAnyValueType<short, SpanHelpers.Negate<short>>(
                     ref Unsafe.As<char, short>(ref MemoryMarshal.GetReference(span)),
diff --git a/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAny3CharValues.cs b/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAny3CharValues.cs
index 5ae583b0f174b..b1f6cb048eda4 100644
--- a/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAny3CharValues.cs
+++ b/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAny3CharValues.cs
@@ -22,7 +22,7 @@ internal override bool ContainsCore(char value) =>
 
         [MethodImpl(MethodImplOptions.AggressiveInlining)]
         internal override int IndexOfAny(ReadOnlySpan<char> span) =>
-            TShouldUsePacked.Value
+            (PackedSpanHelpers.PackedIndexOfIsSupported && TShouldUsePacked.Value)
                 ? PackedSpanHelpers.IndexOfAny(ref MemoryMarshal.GetReference(span), _e0, _e1, _e2, span.Length)
                 : SpanHelpers.NonPackedIndexOfAnyValueType<short, SpanHelpers.DontNegate<short>>(
                     ref Unsafe.As<char, short>(ref MemoryMarshal.GetReference(span)),
@@ -33,7 +33,7 @@ ref Unsafe.As<char, short>(ref MemoryMarshal.GetReference(span)),
 
         [MethodImpl(MethodImplOptions.AggressiveInlining)]
         internal override int IndexOfAnyExcept(ReadOnlySpan<char> span) =>
-            TShouldUsePacked.Value
+            (PackedSpanHelpers.PackedIndexOfIsSupported && TShouldUsePacked.Value)
                 ? PackedSpanHelpers.IndexOfAnyExcept(ref MemoryMarshal.GetReference(span), _e0, _e1, _e2, span.Length)
                 : SpanHelpers.NonPackedIndexOfAnyValueType<short, SpanHelpers.Negate<short>>(
                     ref Unsafe.As<char, short>(ref MemoryMarshal.GetReference(span)),
diff --git a/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAnyCharValuesInRange.cs b/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAnyCharValuesInRange.cs
index 018ef273b4839..0cde365d4e3a1 100644
--- a/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAnyCharValuesInRange.cs
+++ b/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAnyCharValuesInRange.cs
@@ -38,7 +38,7 @@ internal override bool ContainsCore(char value) =>
 
         [MethodImpl(MethodImplOptions.AggressiveInlining)]
         internal override int IndexOfAny(ReadOnlySpan<char> span) =>
-            TShouldUsePacked.Value
+            (PackedSpanHelpers.PackedIndexOfIsSupported && TShouldUsePacked.Value)
                 ? PackedSpanHelpers.IndexOfAnyInRange(ref MemoryMarshal.GetReference(span), _lowInclusive, _rangeInclusive, span.Length)
                 : SpanHelpers.NonPackedIndexOfAnyInRangeUnsignedNumber<ushort, SpanHelpers.DontNegate<ushort>>(
                     ref Unsafe.As<char, ushort>(ref MemoryMarshal.GetReference(span)),
@@ -48,7 +48,7 @@ ref Unsafe.As<char, ushort>(ref MemoryMarshal.GetReference(span)),
 
         [MethodImpl(MethodImplOptions.AggressiveInlining)]
         internal override int IndexOfAnyExcept(ReadOnlySpan<char> span) =>
-            TShouldUsePacked.Value
+            (PackedSpanHelpers.PackedIndexOfIsSupported && TShouldUsePacked.Value)
                 ? PackedSpanHelpers.IndexOfAnyExceptInRange(ref MemoryMarshal.GetReference(span), _lowInclusive, _rangeInclusive, span.Length)
                 : SpanHelpers.NonPackedIndexOfAnyInRangeUnsignedNumber<ushort, SpanHelpers.Negate<ushort>>(
                     ref Unsafe.As<char, ushort>(ref MemoryMarshal.GetReference(span)),
diff --git a/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAnyValues.cs b/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAnyValues.cs
index 24c62bd92b969..cf39598f2e847 100644
--- a/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAnyValues.cs
+++ b/src/libraries/System.Private.CoreLib/src/System/IndexOfAnyValues/IndexOfAnyValues.cs
@@ -80,7 +80,7 @@ public static IndexOfAnyValues<char> Create(ReadOnlySpan<char> values)
             if (values.Length == 1)
             {
                 char value = values[0];
-                return PackedSpanHelpers.CanUsePackedIndexOf(value)
+                return PackedSpanHelpers.PackedIndexOfIsSupported && PackedSpanHelpers.CanUsePackedIndexOf(value)
                     ? new IndexOfAny1CharValue<TrueConst>(value)
                     : new IndexOfAny1CharValue<FalseConst>(value);
             }
@@ -95,7 +95,7 @@ public static IndexOfAnyValues<char> Create(ReadOnlySpan<char> values)
             {
                 char value0 = values[0];
                 char value1 = values[1];
-                return PackedSpanHelpers.CanUsePackedIndexOf(value0) && PackedSpanHelpers.CanUsePackedIndexOf(value1)
+                return PackedSpanHelpers.PackedIndexOfIsSupported && PackedSpanHelpers.CanUsePackedIndexOf(value0) && PackedSpanHelpers.CanUsePackedIndexOf(value1)
                     ? new IndexOfAny2CharValue<TrueConst>(value0, value1)
                     : new IndexOfAny2CharValue<FalseConst>(value0, value1);
             }
@@ -105,7 +105,7 @@ public static IndexOfAnyValues<char> Create(ReadOnlySpan<char> values)
                 char value0 = values[0];
                 char value1 = values[1];
                 char value2 = values[2];
-                return PackedSpanHelpers.CanUsePackedIndexOf(value0) && PackedSpanHelpers.CanUsePackedIndexOf(value1) && PackedSpanHelpers.CanUsePackedIndexOf(value2)
+                return PackedSpanHelpers.PackedIndexOfIsSupported && PackedSpanHelpers.PackedIndexOfIsSupported && PackedSpanHelpers.CanUsePackedIndexOf(value0) && PackedSpanHelpers.CanUsePackedIndexOf(value1) && PackedSpanHelpers.CanUsePackedIndexOf(value2)
                     ? new IndexOfAny3CharValue<TrueConst>(value0, value1, value2)
                     : new IndexOfAny3CharValue<FalseConst>(value0, value1, value2);
             }
@@ -185,7 +185,7 @@ ref Unsafe.As<char, short>(ref MemoryMarshal.GetReference(values)),
             }
 
             Debug.Assert(typeof(T) == typeof(char));
-            return (IndexOfAnyValues<T>)(object)(PackedSpanHelpers.CanUsePackedIndexOf(min) && PackedSpanHelpers.CanUsePackedIndexOf(max)
+            return (IndexOfAnyValues<T>)(object)(PackedSpanHelpers.PackedIndexOfIsSupported && PackedSpanHelpers.PackedIndexOfIsSupported && PackedSpanHelpers.CanUsePackedIndexOf(min) && PackedSpanHelpers.CanUsePackedIndexOf(max)
                 ? new IndexOfAnyCharValuesInRange<TrueConst>(*(char*)&min, *(char*)&max)
                 : new IndexOfAnyCharValuesInRange<FalseConst>(*(char*)&min, *(char*)&max));
         }
diff --git a/src/libraries/System.Private.CoreLib/src/System/SpanHelpers.T.cs b/src/libraries/System.Private.CoreLib/src/System/SpanHelpers.T.cs
index d3d643f13ee64..9e0fc123ffc8c 100644
--- a/src/libraries/System.Private.CoreLib/src/System/SpanHelpers.T.cs
+++ b/src/libraries/System.Private.CoreLib/src/System/SpanHelpers.T.cs
@@ -1306,7 +1306,7 @@ public static int SequenceCompareTo<T>(ref T first, int firstLength, ref T secon
         [MethodImpl(MethodImplOptions.AggressiveInlining)]
         internal static unsafe bool ContainsValueType<T>(ref T searchSpace, T value, int length) where T : struct, INumber<T>
         {
-            if (PackedSpanHelpers.CanUsePackedIndexOf(value))
+            if (PackedSpanHelpers.PackedIndexOfIsSupported && PackedSpanHelpers.CanUsePackedIndexOf(value))
             {
                 return PackedSpanHelpers.Contains(ref Unsafe.As<T, short>(ref searchSpace), *(short*)&value, length);
             }
@@ -1448,7 +1448,7 @@ private static unsafe int IndexOfValueType<TValue, TNegator>(ref TValue searchSp
             where TValue : struct, INumber<TValue>
             where TNegator : struct, INegator<TValue>
         {
-            if (PackedSpanHelpers.CanUsePackedIndexOf(value))
+            if (PackedSpanHelpers.PackedIndexOfIsSupported && PackedSpanHelpers.CanUsePackedIndexOf(value))
             {
                 return typeof(TNegator) == typeof(DontNegate<short>)
                     ? PackedSpanHelpers.IndexOf(ref Unsafe.As<TValue, char>(ref searchSpace), *(char*)&value, length)
@@ -1605,7 +1605,7 @@ private static unsafe int IndexOfAnyValueType<TValue, TNegator>(ref TValue searc
             where TValue : struct, INumber<TValue>
             where TNegator : struct, INegator<TValue>
         {
-            if (PackedSpanHelpers.CanUsePackedIndexOf(value0) && PackedSpanHelpers.CanUsePackedIndexOf(value1))
+            if (PackedSpanHelpers.PackedIndexOfIsSupported && PackedSpanHelpers.CanUsePackedIndexOf(value0) && PackedSpanHelpers.CanUsePackedIndexOf(value1))
             {
                 return typeof(TNegator) == typeof(DontNegate<short>)
                     ? PackedSpanHelpers.IndexOfAny(ref Unsafe.As<TValue, char>(ref searchSpace), *(char*)&value0, *(char*)&value1, length)
@@ -1782,7 +1782,7 @@ private static unsafe int IndexOfAnyValueType<TValue, TNegator>(ref TValue searc
             where TValue : struct, INumber<TValue>
             where TNegator : struct, INegator<TValue>
         {
-            if (PackedSpanHelpers.CanUsePackedIndexOf(value0) && PackedSpanHelpers.CanUsePackedIndexOf(value1) && PackedSpanHelpers.CanUsePackedIndexOf(value2))
+            if (PackedSpanHelpers.PackedIndexOfIsSupported && PackedSpanHelpers.CanUsePackedIndexOf(value0) && PackedSpanHelpers.CanUsePackedIndexOf(value1) && PackedSpanHelpers.CanUsePackedIndexOf(value2))
             {
                 return typeof(TNegator) == typeof(DontNegate<short>)
                     ? PackedSpanHelpers.IndexOfAny(ref Unsafe.As<TValue, char>(ref searchSpace), *(char*)&value0, *(char*)&value1, *(char*)&value2, length)
@@ -3085,7 +3085,7 @@ private static unsafe int IndexOfAnyInRangeUnsignedNumber<T, TNegator>(ref T sea
             where T : struct, IUnsignedNumber<T>, IComparisonOperators<T, T, bool>
             where TNegator : struct, INegator<T>
         {
-            if (PackedSpanHelpers.CanUsePackedIndexOf(lowInclusive) && PackedSpanHelpers.CanUsePackedIndexOf(highInclusive) && highInclusive >= lowInclusive)
+            if (PackedSpanHelpers.PackedIndexOfIsSupported && PackedSpanHelpers.CanUsePackedIndexOf(lowInclusive) && PackedSpanHelpers.CanUsePackedIndexOf(highInclusive) && highInclusive >= lowInclusive)
             {
                 ref char charSearchSpace = ref Unsafe.As<T, char>(ref searchSpace);
                 char charLowInclusive = *(char*)&lowInclusive;
diff --git a/src/mono/wasm/build/ILLink.Substitutions.NoWasmIntrinsics.xml b/src/mono/wasm/build/ILLink.Substitutions.NoWasmIntrinsics.xml
index 5e2282cae353c..98b58c5bb4904 100644
--- a/src/mono/wasm/build/ILLink.Substitutions.NoWasmIntrinsics.xml
+++ b/src/mono/wasm/build/ILLink.Substitutions.NoWasmIntrinsics.xml
@@ -9,5 +9,14 @@
     <type fullname="System.Runtime.Intrinsics.Wasm.PackedSimd">
       <method signature="System.Boolean get_IsSupported()" body="stub" value="false" />
     </type>
+    <type fullname="System.Runtime.Intrinsics.X86.X86Base">
+      <method signature="System.Boolean get_IsSupported()" body="stub" value="false" />
+    </type>
+    <type fullname="System.Runtime.Intrinsics.X86.Sse">
+      <method signature="System.Boolean get_IsSupported()" body="stub" value="false" />
+    </type>
+    <type fullname="System.Runtime.Intrinsics.X86.Sse2">
+      <method signature="System.Boolean get_IsSupported()" body="stub" value="false" />
+    </type>
   </assembly>
 </linker>