diff --git a/compiler/rustc_codegen_gcc/src/asm.rs b/compiler/rustc_codegen_gcc/src/asm.rs
index 9b679019e96ce..949df2a36fe71 100644
--- a/compiler/rustc_codegen_gcc/src/asm.rs
+++ b/compiler/rustc_codegen_gcc/src/asm.rs
@@ -541,7 +541,7 @@ impl<'a, 'gcc, 'tcx> AsmBuilderMethods<'tcx> for Builder<'a, 'gcc, 'tcx> {
             let builtin_unreachable: RValue<'gcc> = unsafe {
                 std::mem::transmute(builtin_unreachable)
             };
-            self.call(self.type_void(), None, None, builtin_unreachable, &[], None);
+            self.call(self.type_void(), None, None, builtin_unreachable, &[], None, false);
         }
 
         // Write results to outputs.
diff --git a/compiler/rustc_codegen_gcc/src/builder.rs b/compiler/rustc_codegen_gcc/src/builder.rs
index f5cda81f6ab86..7eca0e1bf94ff 100644
--- a/compiler/rustc_codegen_gcc/src/builder.rs
+++ b/compiler/rustc_codegen_gcc/src/builder.rs
@@ -592,12 +592,13 @@ impl<'a, 'gcc, 'tcx> BuilderMethods<'a, 'tcx> for Builder<'a, 'gcc, 'tcx> {
         then: Block<'gcc>,
         catch: Block<'gcc>,
         _funclet: Option<&Funclet>,
+        _is_drop: bool
     ) -> RValue<'gcc> {
         let try_block = self.current_func().new_block("try");
 
         let current_block = self.block.clone();
         self.block = try_block;
-        let call = self.call(typ, fn_attrs, None, func, args, None); // TODO(antoyo): use funclet here?
+        let call = self.call(typ, fn_attrs, None, func, args, None, false); // TODO(antoyo): use funclet here?
         self.block = current_block;
 
         let return_value =
@@ -629,8 +630,9 @@ impl<'a, 'gcc, 'tcx> BuilderMethods<'a, 'tcx> for Builder<'a, 'gcc, 'tcx> {
         then: Block<'gcc>,
         catch: Block<'gcc>,
         _funclet: Option<&Funclet>,
+        _is_drop: bool
     ) -> RValue<'gcc> {
-        let call_site = self.call(typ, fn_attrs, None, func, args, None);
+        let call_site = self.call(typ, fn_attrs, None, func, args, None, false);
         let condition = self.context.new_rvalue_from_int(self.bool_type, 1);
         self.llbb().end_with_conditional(self.location, condition, then, catch);
         if let Some(_fn_abi) = fn_abi {
@@ -1667,6 +1669,7 @@ impl<'a, 'gcc, 'tcx> BuilderMethods<'a, 'tcx> for Builder<'a, 'gcc, 'tcx> {
         func: RValue<'gcc>,
         args: &[RValue<'gcc>],
         funclet: Option<&Funclet>,
+        _is_drop: bool
     ) -> RValue<'gcc> {
         // FIXME(antoyo): remove when having a proper API.
         let gcc_func = unsafe { std::mem::transmute(func) };
diff --git a/compiler/rustc_codegen_gcc/src/intrinsic/mod.rs b/compiler/rustc_codegen_gcc/src/intrinsic/mod.rs
index a6c8b72e851b2..bef7d271cda46 100644
--- a/compiler/rustc_codegen_gcc/src/intrinsic/mod.rs
+++ b/compiler/rustc_codegen_gcc/src/intrinsic/mod.rs
@@ -133,6 +133,7 @@ impl<'a, 'gcc, 'tcx> IntrinsicCallMethods<'tcx> for Builder<'a, 'gcc, 'tcx> {
                     func,
                     &args.iter().map(|arg| arg.immediate()).collect::<Vec<_>>(),
                     None,
+                    false
                 )
             }
             sym::likely => self.expect(args[0].immediate(), true),
@@ -401,7 +402,7 @@ impl<'a, 'gcc, 'tcx> IntrinsicCallMethods<'tcx> for Builder<'a, 'gcc, 'tcx> {
     fn abort(&mut self) {
         let func = self.context.get_builtin_function("abort");
         let func: RValue<'gcc> = unsafe { std::mem::transmute(func) };
-        self.call(self.type_void(), None, None, func, &[], None);
+        self.call(self.type_void(), None, None, func, &[], None, false);
     }
 
     fn assume(&mut self, value: Self::Value) {
@@ -1103,7 +1104,7 @@ fn try_intrinsic<'a, 'b, 'gcc, 'tcx>(
     dest: RValue<'gcc>,
 ) {
     if bx.sess().panic_strategy() == PanicStrategy::Abort {
-        bx.call(bx.type_void(), None, None, try_func, &[data], None);
+        bx.call(bx.type_void(), None, None, try_func, &[data], None, false);
         // Return 0 unconditionally from the intrinsic call;
         // we can never unwind.
         let ret_align = bx.tcx.data_layout.i32_align.abi;
@@ -1177,21 +1178,21 @@ fn codegen_gnu_try<'gcc>(
         let zero = bx.cx.context.new_rvalue_zero(bx.int_type);
         let ptr = bx.cx.context.new_call(None, eh_pointer_builtin, &[zero]);
         let catch_ty = bx.type_func(&[bx.type_i8p(), bx.type_i8p()], bx.type_void());
-        bx.call(catch_ty, None, None, catch_func, &[data, ptr], None);
+        bx.call(catch_ty, None, None, catch_func, &[data, ptr], None, false);
         bx.ret(bx.const_i32(1));
 
         // NOTE: the blocks must be filled before adding the try/catch, otherwise gcc will not
         // generate a try/catch.
         // FIXME(antoyo): add a check in the libgccjit API to prevent this.
         bx.switch_to_block(current_block);
-        bx.invoke(try_func_ty, None, None, try_func, &[data], then, catch, None);
+        bx.invoke(try_func_ty, None, None, try_func, &[data], then, catch, None, false);
     });
 
     let func = unsafe { std::mem::transmute(func) };
 
     // Note that no invoke is used here because by definition this function
     // can't panic (that's what it's catching).
-    let ret = bx.call(llty, None, None, func, &[try_func, data, catch_func], None);
+    let ret = bx.call(llty, None, None, func, &[try_func, data, catch_func], None, false);
     let i32_align = bx.tcx().data_layout.i32_align.abi;
     bx.store(ret, dest, i32_align);
 }
diff --git a/compiler/rustc_codegen_llvm/src/asm.rs b/compiler/rustc_codegen_llvm/src/asm.rs
index 74539d4d49570..681fb37e0855f 100644
--- a/compiler/rustc_codegen_llvm/src/asm.rs
+++ b/compiler/rustc_codegen_llvm/src/asm.rs
@@ -466,11 +466,11 @@ pub(crate) fn inline_asm_call<'ll>(
 
             let call = if !labels.is_empty() {
                 assert!(catch_funclet.is_none());
-                bx.callbr(fty, None, None, v, inputs, dest.unwrap(), labels, None)
+                bx.callbr(fty, None, None, v, inputs, dest.unwrap(), labels, None, false)
             } else if let Some((catch, funclet)) = catch_funclet {
-                bx.invoke(fty, None, None, v, inputs, dest.unwrap(), catch, funclet)
+                bx.invoke(fty, None, None, v, inputs, dest.unwrap(), catch, funclet, false)
             } else {
-                bx.call(fty, None, None, v, inputs, None)
+                bx.call(fty, None, None, v, inputs, None, false)
             };
 
             // Store mark in a metadata node so we can map LLVM errors
diff --git a/compiler/rustc_codegen_llvm/src/builder.rs b/compiler/rustc_codegen_llvm/src/builder.rs
index 63e59ea13fc35..7efa8319e0fae 100644
--- a/compiler/rustc_codegen_llvm/src/builder.rs
+++ b/compiler/rustc_codegen_llvm/src/builder.rs
@@ -21,7 +21,10 @@ use rustc_middle::ty::layout::{
 };
 use rustc_middle::ty::{self, Ty, TyCtxt};
 use rustc_span::Span;
-use rustc_symbol_mangling::typeid::{kcfi_typeid_for_fnabi, typeid_for_fnabi, TypeIdOptions};
+use rustc_symbol_mangling::typeid::{
+    kcfi_typeid_for_drop_fnabi, kcfi_typeid_for_fnabi, typeid_for_drop_fnabi, typeid_for_fnabi,
+    TypeIdOptions,
+};
 use rustc_target::abi::{self, call::FnAbi, Align, Size, WrappingRange};
 use rustc_target::spec::{HasTargetSpec, SanitizerSet, Target};
 use smallvec::SmallVec;
@@ -221,6 +224,7 @@ impl<'a, 'll, 'tcx> BuilderMethods<'a, 'tcx> for Builder<'a, 'll, 'tcx> {
         then: &'ll BasicBlock,
         catch: &'ll BasicBlock,
         funclet: Option<&Funclet<'ll>>,
+        is_drop: bool,
     ) -> &'ll Value {
         debug!("invoke {:?} with args ({:?})", llfn, args);
 
@@ -233,10 +237,10 @@ impl<'a, 'll, 'tcx> BuilderMethods<'a, 'tcx> for Builder<'a, 'll, 'tcx> {
         }
 
         // Emit CFI pointer type membership test
-        self.cfi_type_test(fn_attrs, fn_abi, llfn);
+        self.cfi_type_test(fn_attrs, fn_abi, llfn, is_drop);
 
         // Emit KCFI operand bundle
-        let kcfi_bundle = self.kcfi_operand_bundle(fn_attrs, fn_abi, llfn);
+        let kcfi_bundle = self.kcfi_operand_bundle(fn_attrs, fn_abi, llfn, is_drop);
         let kcfi_bundle = kcfi_bundle.as_ref().map(|b| &*b.raw);
         if let Some(kcfi_bundle) = kcfi_bundle {
             bundles.push(kcfi_bundle);
@@ -1231,6 +1235,7 @@ impl<'a, 'll, 'tcx> BuilderMethods<'a, 'tcx> for Builder<'a, 'll, 'tcx> {
         llfn: &'ll Value,
         args: &[&'ll Value],
         funclet: Option<&Funclet<'ll>>,
+        is_drop: bool,
     ) -> &'ll Value {
         debug!("call {:?} with args ({:?})", llfn, args);
 
@@ -1243,10 +1248,10 @@ impl<'a, 'll, 'tcx> BuilderMethods<'a, 'tcx> for Builder<'a, 'll, 'tcx> {
         }
 
         // Emit CFI pointer type membership test
-        self.cfi_type_test(fn_attrs, fn_abi, llfn);
+        self.cfi_type_test(fn_attrs, fn_abi, llfn, is_drop);
 
         // Emit KCFI operand bundle
-        let kcfi_bundle = self.kcfi_operand_bundle(fn_attrs, fn_abi, llfn);
+        let kcfi_bundle = self.kcfi_operand_bundle(fn_attrs, fn_abi, llfn, is_drop);
         let kcfi_bundle = kcfi_bundle.as_ref().map(|b| &*b.raw);
         if let Some(kcfi_bundle) = kcfi_bundle {
             bundles.push(kcfi_bundle);
@@ -1468,7 +1473,7 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
 
     pub(crate) fn call_intrinsic(&mut self, intrinsic: &str, args: &[&'ll Value]) -> &'ll Value {
         let (ty, f) = self.cx.get_intrinsic(intrinsic);
-        self.call(ty, None, None, f, args, None)
+        self.call(ty, None, None, f, args, None, false)
     }
 
     fn call_lifetime_intrinsic(&mut self, intrinsic: &str, ptr: &'ll Value, size: Size) {
@@ -1526,7 +1531,7 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
             format!("llvm.{instr}.sat.i{int_width}.f{float_width}")
         };
         let f = self.declare_cfn(&name, llvm::UnnamedAddr::No, self.type_func(&[src_ty], dest_ty));
-        self.call(self.type_func(&[src_ty], dest_ty), None, None, f, &[val], None)
+        self.call(self.type_func(&[src_ty], dest_ty), None, None, f, &[val], None, false)
     }
 
     pub(crate) fn landing_pad(
@@ -1554,6 +1559,7 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
         default_dest: &'ll BasicBlock,
         indirect_dest: &[&'ll BasicBlock],
         funclet: Option<&Funclet<'ll>>,
+        is_drop: bool,
     ) -> &'ll Value {
         debug!("invoke {:?} with args ({:?})", llfn, args);
 
@@ -1566,10 +1572,10 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
         }
 
         // Emit CFI pointer type membership test
-        self.cfi_type_test(fn_attrs, fn_abi, llfn);
+        self.cfi_type_test(fn_attrs, fn_abi, llfn, is_drop);
 
         // Emit KCFI operand bundle
-        let kcfi_bundle = self.kcfi_operand_bundle(fn_attrs, fn_abi, llfn);
+        let kcfi_bundle = self.kcfi_operand_bundle(fn_attrs, fn_abi, llfn, is_drop);
         let kcfi_bundle = kcfi_bundle.as_ref().map(|b| &*b.raw);
         if let Some(kcfi_bundle) = kcfi_bundle {
             bundles.push(kcfi_bundle);
@@ -1602,6 +1608,7 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
         fn_attrs: Option<&CodegenFnAttrs>,
         fn_abi: Option<&FnAbi<'tcx, Ty<'tcx>>>,
         llfn: &'ll Value,
+        is_drop: bool,
     ) {
         let is_indirect_call = unsafe { llvm::LLVMRustIsNonGVFunctionPointerTy(llfn) };
         if self.tcx.sess.is_sanitizer_cfi_enabled()
@@ -1622,7 +1629,11 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
                 options.insert(TypeIdOptions::NORMALIZE_INTEGERS);
             }
 
-            let typeid = typeid_for_fnabi(self.tcx, fn_abi, options);
+            let typeid = if is_drop {
+                typeid_for_drop_fnabi(self.tcx, fn_abi, options)
+            } else {
+                typeid_for_fnabi(self.tcx, fn_abi, options)
+            };
             let typeid_metadata = self.cx.typeid_metadata(typeid).unwrap();
 
             // Test whether the function pointer is associated with the type identifier.
@@ -1645,6 +1656,7 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
         fn_attrs: Option<&CodegenFnAttrs>,
         fn_abi: Option<&FnAbi<'tcx, Ty<'tcx>>>,
         llfn: &'ll Value,
+        is_drop: bool,
     ) -> Option<llvm::OperandBundleDef<'ll>> {
         let is_indirect_call = unsafe { llvm::LLVMRustIsNonGVFunctionPointerTy(llfn) };
         let kcfi_bundle = if self.tcx.sess.is_sanitizer_kcfi_enabled()
@@ -1665,7 +1677,11 @@ impl<'a, 'll, 'tcx> Builder<'a, 'll, 'tcx> {
                 options.insert(TypeIdOptions::NORMALIZE_INTEGERS);
             }
 
-            let kcfi_typeid = kcfi_typeid_for_fnabi(self.tcx, fn_abi, options);
+            let kcfi_typeid = if is_drop {
+                kcfi_typeid_for_drop_fnabi(self.tcx, fn_abi, options)
+            } else {
+                kcfi_typeid_for_fnabi(self.tcx, fn_abi, options)
+            };
             Some(llvm::OperandBundleDef::new("kcfi", &[self.const_u32(kcfi_typeid)]))
         } else {
             None
diff --git a/compiler/rustc_codegen_llvm/src/intrinsic.rs b/compiler/rustc_codegen_llvm/src/intrinsic.rs
index 71b69a94e99e7..f62d0644be802 100644
--- a/compiler/rustc_codegen_llvm/src/intrinsic.rs
+++ b/compiler/rustc_codegen_llvm/src/intrinsic.rs
@@ -181,6 +181,7 @@ impl<'ll, 'tcx> IntrinsicCallMethods<'tcx> for Builder<'_, 'll, 'tcx> {
                     simple_fn,
                     &args.iter().map(|arg| arg.immediate()).collect::<Vec<_>>(),
                     None,
+                    false,
                 )
             }
             sym::likely => {
@@ -539,7 +540,7 @@ fn catch_unwind_intrinsic<'ll>(
 ) {
     if bx.sess().panic_strategy() == PanicStrategy::Abort {
         let try_func_ty = bx.type_func(&[bx.type_ptr()], bx.type_void());
-        bx.call(try_func_ty, None, None, try_func, &[data], None);
+        bx.call(try_func_ty, None, None, try_func, &[data], None, false);
         // Return 0 unconditionally from the intrinsic call;
         // we can never unwind.
         let ret_align = bx.tcx().data_layout.i32_align.abi;
@@ -640,7 +641,7 @@ fn codegen_msvc_try<'ll>(
         let ptr_align = bx.tcx().data_layout.pointer_align.abi;
         let slot = bx.alloca(bx.type_ptr(), ptr_align);
         let try_func_ty = bx.type_func(&[bx.type_ptr()], bx.type_void());
-        bx.invoke(try_func_ty, None, None, try_func, &[data], normal, catchswitch, None);
+        bx.invoke(try_func_ty, None, None, try_func, &[data], normal, catchswitch, None, false);
 
         bx.switch_to_block(normal);
         bx.ret(bx.const_i32(0));
@@ -684,7 +685,7 @@ fn codegen_msvc_try<'ll>(
         let funclet = bx.catch_pad(cs, &[tydesc, flags, slot]);
         let ptr = bx.load(bx.type_ptr(), slot, ptr_align);
         let catch_ty = bx.type_func(&[bx.type_ptr(), bx.type_ptr()], bx.type_void());
-        bx.call(catch_ty, None, None, catch_func, &[data, ptr], Some(&funclet));
+        bx.call(catch_ty, None, None, catch_func, &[data, ptr], Some(&funclet), false);
         bx.catch_ret(&funclet, caught);
 
         // The flag value of 64 indicates a "catch-all".
@@ -692,7 +693,7 @@ fn codegen_msvc_try<'ll>(
         let flags = bx.const_i32(64);
         let null = bx.const_null(bx.type_ptr());
         let funclet = bx.catch_pad(cs, &[null, flags, null]);
-        bx.call(catch_ty, None, None, catch_func, &[data, null], Some(&funclet));
+        bx.call(catch_ty, None, None, catch_func, &[data, null], Some(&funclet), false);
         bx.catch_ret(&funclet, caught);
 
         bx.switch_to_block(caught);
@@ -701,7 +702,7 @@ fn codegen_msvc_try<'ll>(
 
     // Note that no invoke is used here because by definition this function
     // can't panic (that's what it's catching).
-    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None);
+    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None, false);
     let i32_align = bx.tcx().data_layout.i32_align.abi;
     bx.store(ret, dest, i32_align);
 }
@@ -750,7 +751,7 @@ fn codegen_wasm_try<'ll>(
         //   }
         //
         let try_func_ty = bx.type_func(&[bx.type_ptr()], bx.type_void());
-        bx.invoke(try_func_ty, None, None, try_func, &[data], normal, catchswitch, None);
+        bx.invoke(try_func_ty, None, None, try_func, &[data], normal, catchswitch, None, false);
 
         bx.switch_to_block(normal);
         bx.ret(bx.const_i32(0));
@@ -766,7 +767,7 @@ fn codegen_wasm_try<'ll>(
         let _sel = bx.call_intrinsic("llvm.wasm.get.ehselector", &[funclet.cleanuppad()]);
 
         let catch_ty = bx.type_func(&[bx.type_ptr(), bx.type_ptr()], bx.type_void());
-        bx.call(catch_ty, None, None, catch_func, &[data, ptr], Some(&funclet));
+        bx.call(catch_ty, None, None, catch_func, &[data, ptr], Some(&funclet), false);
         bx.catch_ret(&funclet, caught);
 
         bx.switch_to_block(caught);
@@ -775,7 +776,7 @@ fn codegen_wasm_try<'ll>(
 
     // Note that no invoke is used here because by definition this function
     // can't panic (that's what it's catching).
-    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None);
+    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None, false);
     let i32_align = bx.tcx().data_layout.i32_align.abi;
     bx.store(ret, dest, i32_align);
 }
@@ -818,7 +819,7 @@ fn codegen_gnu_try<'ll>(
         let data = llvm::get_param(bx.llfn(), 1);
         let catch_func = llvm::get_param(bx.llfn(), 2);
         let try_func_ty = bx.type_func(&[bx.type_ptr()], bx.type_void());
-        bx.invoke(try_func_ty, None, None, try_func, &[data], then, catch, None);
+        bx.invoke(try_func_ty, None, None, try_func, &[data], then, catch, None, false);
 
         bx.switch_to_block(then);
         bx.ret(bx.const_i32(0));
@@ -836,13 +837,13 @@ fn codegen_gnu_try<'ll>(
         bx.add_clause(vals, tydesc);
         let ptr = bx.extract_value(vals, 0);
         let catch_ty = bx.type_func(&[bx.type_ptr(), bx.type_ptr()], bx.type_void());
-        bx.call(catch_ty, None, None, catch_func, &[data, ptr], None);
+        bx.call(catch_ty, None, None, catch_func, &[data, ptr], None, false);
         bx.ret(bx.const_i32(1));
     });
 
     // Note that no invoke is used here because by definition this function
     // can't panic (that's what it's catching).
-    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None);
+    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None, false);
     let i32_align = bx.tcx().data_layout.i32_align.abi;
     bx.store(ret, dest, i32_align);
 }
@@ -882,7 +883,7 @@ fn codegen_emcc_try<'ll>(
         let data = llvm::get_param(bx.llfn(), 1);
         let catch_func = llvm::get_param(bx.llfn(), 2);
         let try_func_ty = bx.type_func(&[bx.type_ptr()], bx.type_void());
-        bx.invoke(try_func_ty, None, None, try_func, &[data], then, catch, None);
+        bx.invoke(try_func_ty, None, None, try_func, &[data], then, catch, None, false);
 
         bx.switch_to_block(then);
         bx.ret(bx.const_i32(0));
@@ -920,13 +921,13 @@ fn codegen_emcc_try<'ll>(
         bx.store(is_rust_panic, catch_data_1, i8_align);
 
         let catch_ty = bx.type_func(&[bx.type_ptr(), bx.type_ptr()], bx.type_void());
-        bx.call(catch_ty, None, None, catch_func, &[data, catch_data], None);
+        bx.call(catch_ty, None, None, catch_func, &[data, catch_data], None, false);
         bx.ret(bx.const_i32(1));
     });
 
     // Note that no invoke is used here because by definition this function
     // can't panic (that's what it's catching).
-    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None);
+    let ret = bx.call(llty, None, None, llfn, &[try_func, data, catch_func], None, false);
     let i32_align = bx.tcx().data_layout.i32_align.abi;
     bx.store(ret, dest, i32_align);
 }
@@ -1439,6 +1440,7 @@ fn generic_simd_intrinsic<'ll, 'tcx>(
             f,
             &args.iter().map(|arg| arg.immediate()).collect::<Vec<_>>(),
             None,
+            false,
         );
         Ok(c)
     }
@@ -1607,6 +1609,7 @@ fn generic_simd_intrinsic<'ll, 'tcx>(
             f,
             &[args[1].immediate(), alignment, mask, args[0].immediate()],
             None,
+            false,
         );
         return Ok(v);
     }
@@ -1706,6 +1709,7 @@ fn generic_simd_intrinsic<'ll, 'tcx>(
             f,
             &[args[1].immediate(), alignment, mask, args[2].immediate()],
             None,
+            false,
         );
         return Ok(v);
     }
@@ -1799,6 +1803,7 @@ fn generic_simd_intrinsic<'ll, 'tcx>(
             f,
             &[args[2].immediate(), args[1].immediate(), alignment, mask],
             None,
+            false,
         );
         return Ok(v);
     }
@@ -1904,6 +1909,7 @@ fn generic_simd_intrinsic<'ll, 'tcx>(
             f,
             &[args[0].immediate(), args[1].immediate(), alignment, mask],
             None,
+            false,
         );
         return Ok(v);
     }
@@ -2352,11 +2358,12 @@ fn generic_simd_intrinsic<'ll, 'tcx>(
                 f,
                 &[args[0].immediate(), bx.const_int(bx.type_i1(), 0)],
                 None,
+                false,
             ))
         } else {
             let fn_ty = bx.type_func(&[vec_ty], vec_ty);
             let f = bx.declare_cfn(llvm_intrinsic, llvm::UnnamedAddr::No, fn_ty);
-            Ok(bx.call(fn_ty, None, None, f, &[args[0].immediate()], None))
+            Ok(bx.call(fn_ty, None, None, f, &[args[0].immediate()], None, false))
         };
     }
 
@@ -2409,7 +2416,7 @@ fn generic_simd_intrinsic<'ll, 'tcx>(
 
         let fn_ty = bx.type_func(&[vec_ty, vec_ty], vec_ty);
         let f = bx.declare_cfn(llvm_intrinsic, llvm::UnnamedAddr::No, fn_ty);
-        let v = bx.call(fn_ty, None, None, f, &[lhs, rhs], None);
+        let v = bx.call(fn_ty, None, None, f, &[lhs, rhs], None, false);
         return Ok(v);
     }
 
diff --git a/compiler/rustc_codegen_ssa/src/base.rs b/compiler/rustc_codegen_ssa/src/base.rs
index c316d19e04119..656c29d044f15 100644
--- a/compiler/rustc_codegen_ssa/src/base.rs
+++ b/compiler/rustc_codegen_ssa/src/base.rs
@@ -482,7 +482,7 @@ pub fn maybe_create_entry_wrapper<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>>(
             (rust_main, start_ty, vec![arg_argc, arg_argv])
         };
 
-        let result = bx.call(start_ty, None, None, start_fn, &args, None);
+        let result = bx.call(start_ty, None, None, start_fn, &args, None, false);
         if cx.sess().target.os.contains("uefi") {
             bx.ret(result);
         } else {
diff --git a/compiler/rustc_codegen_ssa/src/mir/block.rs b/compiler/rustc_codegen_ssa/src/mir/block.rs
index 02e7bb05b7709..b77a4594a136c 100644
--- a/compiler/rustc_codegen_ssa/src/mir/block.rs
+++ b/compiler/rustc_codegen_ssa/src/mir/block.rs
@@ -157,6 +157,7 @@ impl<'a, 'tcx> TerminatorCodegenHelper<'tcx> {
         destination: Option<(ReturnDest<'tcx, Bx::Value>, mir::BasicBlock)>,
         mut unwind: mir::UnwindAction,
         copied_constant_arguments: &[PlaceRef<'tcx, <Bx as BackendTypes>::Value>],
+        is_drop: bool,
         mergeable_succ: bool,
     ) -> MergingSucc {
         // If there is a cleanup block and the function we're calling can unwind, then
@@ -210,6 +211,7 @@ impl<'a, 'tcx> TerminatorCodegenHelper<'tcx> {
                 ret_llbb,
                 unwind_block,
                 self.funclet(fx),
+                is_drop,
             );
             if fx.mir[self.bb].is_cleanup {
                 bx.apply_attrs_to_cleanup_callsite(invokeret);
@@ -225,7 +227,8 @@ impl<'a, 'tcx> TerminatorCodegenHelper<'tcx> {
             }
             MergingSucc::False
         } else {
-            let llret = bx.call(fn_ty, fn_attrs, Some(fn_abi), fn_ptr, llargs, self.funclet(fx));
+            let llret =
+                bx.call(fn_ty, fn_attrs, Some(fn_abi), fn_ptr, llargs, self.funclet(fx), false);
             if fx.mir[self.bb].is_cleanup {
                 bx.apply_attrs_to_cleanup_callsite(llret);
             }
@@ -582,6 +585,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
             Some((ReturnDest::Nothing, target)),
             unwind,
             &[],
+            true,
             mergeable_succ,
         )
     }
@@ -661,7 +665,8 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
         let (fn_abi, llfn) = common::build_langcall(bx, Some(span), lang_item);
 
         // Codegen the actual panic invoke/call.
-        let merging_succ = helper.do_call(self, bx, fn_abi, llfn, &args, None, unwind, &[], false);
+        let merging_succ =
+            helper.do_call(self, bx, fn_abi, llfn, &args, None, unwind, &[], false, false);
         assert_eq!(merging_succ, MergingSucc::False);
         MergingSucc::False
     }
@@ -690,6 +695,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
             mir::UnwindAction::Unreachable,
             &[],
             false,
+            false,
         );
         assert_eq!(merging_succ, MergingSucc::False);
     }
@@ -751,6 +757,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
                     target.as_ref().map(|bb| (ReturnDest::Nothing, *bb)),
                     unwind,
                     &[],
+                    false,
                     mergeable_succ,
                 )
             } else {
@@ -1106,6 +1113,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
             destination,
             unwind,
             &copied_constant_arguments,
+            false,
             mergeable_succ,
         )
     }
@@ -1667,7 +1675,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
         let (fn_abi, fn_ptr) = common::build_langcall(&bx, None, reason.lang_item());
         let fn_ty = bx.fn_decl_backend_type(fn_abi);
 
-        let llret = bx.call(fn_ty, None, Some(fn_abi), fn_ptr, &[], funclet.as_ref());
+        let llret = bx.call(fn_ty, None, Some(fn_abi), fn_ptr, &[], funclet.as_ref(), false);
         bx.apply_attrs_to_cleanup_callsite(llret);
 
         bx.unreachable();
diff --git a/compiler/rustc_codegen_ssa/src/mir/rvalue.rs b/compiler/rustc_codegen_ssa/src/mir/rvalue.rs
index 8159f76b421b3..2b35b362c3964 100644
--- a/compiler/rustc_codegen_ssa/src/mir/rvalue.rs
+++ b/compiler/rustc_codegen_ssa/src/mir/rvalue.rs
@@ -715,7 +715,7 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
                     } else {
                         None
                     };
-                    bx.call(fn_ty, fn_attrs, Some(fn_abi), fn_ptr, &[], None)
+                    bx.call(fn_ty, fn_attrs, Some(fn_abi), fn_ptr, &[], None, false)
                 } else {
                     bx.get_static(def_id)
                 };
diff --git a/compiler/rustc_codegen_ssa/src/size_of_val.rs b/compiler/rustc_codegen_ssa/src/size_of_val.rs
index 087836ca37de0..8c131f077dc41 100644
--- a/compiler/rustc_codegen_ssa/src/size_of_val.rs
+++ b/compiler/rustc_codegen_ssa/src/size_of_val.rs
@@ -69,7 +69,15 @@ pub fn size_and_align_of_dst<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>>(
             // (But we are in good company, this code is duplicated plenty of times.)
             let fn_ty = bx.fn_decl_backend_type(fn_abi);
 
-            bx.call(fn_ty, /* fn_attrs */ None, Some(fn_abi), llfn, &[msg.0, msg.1], None);
+            bx.call(
+                fn_ty,
+                /* fn_attrs */ None,
+                Some(fn_abi),
+                llfn,
+                &[msg.0, msg.1],
+                None,
+                false,
+            );
 
             // This function does not return so we can now return whatever we want.
             let size = bx.const_usize(layout.size.bytes());
diff --git a/compiler/rustc_codegen_ssa/src/traits/builder.rs b/compiler/rustc_codegen_ssa/src/traits/builder.rs
index 36f37e3791bc5..2f140ea363f02 100644
--- a/compiler/rustc_codegen_ssa/src/traits/builder.rs
+++ b/compiler/rustc_codegen_ssa/src/traits/builder.rs
@@ -80,6 +80,7 @@ pub trait BuilderMethods<'a, 'tcx>:
         then: Self::BasicBlock,
         catch: Self::BasicBlock,
         funclet: Option<&Self::Funclet>,
+        is_drop: bool,
     ) -> Self::Value;
     fn unreachable(&mut self);
 
@@ -339,6 +340,7 @@ pub trait BuilderMethods<'a, 'tcx>:
         llfn: Self::Value,
         args: &[Self::Value],
         funclet: Option<&Self::Funclet>,
+        is_drop: bool,
     ) -> Self::Value;
     fn zext(&mut self, val: Self::Value, dest_ty: Self::Type) -> Self::Value;
 
diff --git a/compiler/rustc_symbol_mangling/src/typeid.rs b/compiler/rustc_symbol_mangling/src/typeid.rs
index 31efeb44c2c25..ab49403568465 100644
--- a/compiler/rustc_symbol_mangling/src/typeid.rs
+++ b/compiler/rustc_symbol_mangling/src/typeid.rs
@@ -21,6 +21,15 @@ bitflags! {
 
 mod typeid_itanium_cxx_abi;
 
+/// Returns a type metadata identifier for the specified drop FnAbi.
+pub fn typeid_for_drop_fnabi<'tcx>(
+    tcx: TyCtxt<'tcx>,
+    fn_abi: &FnAbi<'tcx, Ty<'tcx>>,
+    options: TypeIdOptions,
+) -> String {
+    typeid_itanium_cxx_abi::typeid_for_drop_fnabi(tcx, fn_abi, options)
+}
+
 /// Returns a type metadata identifier for the specified FnAbi.
 pub fn typeid_for_fnabi<'tcx>(
     tcx: TyCtxt<'tcx>,
@@ -52,6 +61,19 @@ pub fn typeid_for_instance<'tcx>(
     )
 }
 
+/// Returns a KCFI type metadata identifier for the specified drop FnAbi.
+pub fn kcfi_typeid_for_drop_fnabi<'tcx>(
+    tcx: TyCtxt<'tcx>,
+    fn_abi: &FnAbi<'tcx, Ty<'tcx>>,
+    options: TypeIdOptions,
+) -> u32 {
+    // A KCFI type metadata identifier is a 32-bit constant produced by taking the lower half of the
+    // xxHash64 of the type metadata identifier. (See llvm/llvm-project@cff5bef.)
+    let mut hash: XxHash64 = Default::default();
+    hash.write(typeid_itanium_cxx_abi::typeid_for_drop_fnabi(tcx, fn_abi, options).as_bytes());
+    hash.finish() as u32
+}
+
 /// Returns a KCFI type metadata identifier for the specified FnAbi.
 pub fn kcfi_typeid_for_fnabi<'tcx>(
     tcx: TyCtxt<'tcx>,
diff --git a/compiler/rustc_symbol_mangling/src/typeid/typeid_itanium_cxx_abi.rs b/compiler/rustc_symbol_mangling/src/typeid/typeid_itanium_cxx_abi.rs
index c2b35acc3eafb..7be1b56fff1be 100644
--- a/compiler/rustc_symbol_mangling/src/typeid/typeid_itanium_cxx_abi.rs
+++ b/compiler/rustc_symbol_mangling/src/typeid/typeid_itanium_cxx_abi.rs
@@ -946,6 +946,7 @@ pub fn transform_fn_trait_fnabi<'tcx>(
 /// * Replaces the concrete self of trait default implementations and trait implementations by a
 ///   reference to a trait object (i.e., performs type erasure).
 /// * Adjusts the type ids of VTableShims.
+/// * Adjusts the type ids of DropGlues.
 /// * Adjusts the type ids of ClosureOnceShims.
 /// * Transforms closure FnAbis into funtion pointer FnAbis.
 /// * Transforms Fn trait FnAbis into function pointers FnAbis.
@@ -957,7 +958,7 @@ pub fn transform_fnabi<'tcx>(
     instance: Option<&Instance<'tcx>>,
 ) -> FnAbi<'tcx, Ty<'tcx>> {
     if let Some(instance) = instance
-        && matches!(instance.def, ty::InstanceDef::Item(..))
+        && matches!(instance.def, ty::InstanceDef::Item(..) | ty::InstanceDef::DropGlue(..))
         && let Some(impl_def_id) = tcx.impl_of_method(instance.def_id())
         && let Some(trait_ref) = tcx.impl_trait_ref(impl_def_id)
         && !fn_abi.args.is_empty()
@@ -1002,6 +1003,31 @@ pub fn transform_fnabi<'tcx>(
     {
         // Adjust the type ids of VTableShims
         return transform_closure_fnabi(tcx, fn_abi, options);
+    } else if let Some(instance) = instance
+        && matches!(instance.def, ty::InstanceDef::DropGlue(..))
+    {
+        // Adjust the type ids of DropGlues
+        if !fn_abi.args.is_empty() {
+            let self_ty = if fn_abi.args[0].layout.ty.is_mutable_ptr() {
+                Ty::new_mut_ref(
+                    tcx,
+                    tcx.lifetimes.re_erased,
+                    new_dynamic_trait(tcx, tcx.lang_items().drop_trait().unwrap(), List::empty()),
+                )
+            } else {
+                Ty::new_imm_ref(
+                    tcx,
+                    tcx.lifetimes.re_erased,
+                    new_dynamic_trait(tcx, tcx.lang_items().drop_trait().unwrap(), List::empty()),
+                )
+            };
+            let mut fn_abi = fn_abi.clone();
+            // HACK(rcvalle): It is okay to not replace or update the entire ArgAbi here because the
+            //   other fields are never used.
+            fn_abi.args[0].layout.ty = self_ty;
+            return fn_abi;
+        }
+        return fn_abi.clone();
     } else if let Some(instance) = instance
         && matches!(instance.def, ty::InstanceDef::ClosureOnceShim { .. })
     {
@@ -1346,6 +1372,37 @@ fn transform_ty<'tcx>(tcx: TyCtxt<'tcx>, ty: Ty<'tcx>, options: TransformTyOptio
     ty
 }
 
+/// Returns a type metadata identifier for the specified drop FnAbi using the Itanium C++ ABI with
+/// vendor extended type qualifiers and types for Rust types that are not used at the FFI boundary.
+pub fn typeid_for_drop_fnabi<'tcx>(
+    tcx: TyCtxt<'tcx>,
+    fn_abi: &FnAbi<'tcx, Ty<'tcx>>,
+    options: TypeIdOptions,
+) -> String {
+    // Transform self into a Drop trait object to match what the drop method's self is transformed
+    // into in transform_fnabi.
+    let self_ty = if fn_abi.args[0].layout.ty.is_mutable_ptr() {
+        Ty::new_mut_ref(
+            tcx,
+            tcx.lifetimes.re_erased,
+            new_dynamic_trait(tcx, tcx.lang_items().drop_trait().unwrap(), List::empty()),
+        )
+    } else {
+        Ty::new_imm_ref(
+            tcx,
+            tcx.lifetimes.re_erased,
+            new_dynamic_trait(tcx, tcx.lang_items().drop_trait().unwrap(), List::empty()),
+        )
+    };
+
+    let mut fn_abi = fn_abi.clone();
+    // HACK(rcvalle): It is okay to not replace or update the entire ArgAbi here because the
+    //   other fields are never used.
+    fn_abi.args[0].layout.ty = self_ty;
+
+    return typeid_for_fnabi(tcx, &fn_abi, options);
+}
+
 /// Returns a type metadata identifier for the specified FnAbi using the Itanium C++ ABI with vendor
 /// extended type qualifiers and types for Rust types that are not used at the FFI boundary.
 #[instrument(level = "trace", skip(tcx))]
diff --git a/tests/ui/sanitizer/cfi-drop-in-place.rs b/tests/ui/sanitizer/cfi-drop-in-place.rs
new file mode 100644
index 0000000000000..3c8428cfaeb35
--- /dev/null
+++ b/tests/ui/sanitizer/cfi-drop-in-place.rs
@@ -0,0 +1,14 @@
+// Verifies that custom drops can be called on arbitraty trait objects.
+//
+//@ needs-sanitizer-cfi
+//@ compile-flags: -Clto -Cprefer-dynamic=off -Ctarget-feature=-crt-static -Zsanitizer=cfi -Copt-level=0
+//@ run-pass
+
+struct CustomDrop;
+impl Drop for CustomDrop {
+    fn drop(&mut self) {}
+}
+
+fn main() {
+    let _ = Box::new(CustomDrop) as Box<dyn Send>;
+}