diff --git a/tests/drivers/uart/uart_async_api/boards/mimxrt1010_evk.overlay b/tests/drivers/uart/uart_async_api/boards/mimxrt1010_evk.overlay
index 02c9390abbc296..4dc4c119d905f7 100644
--- a/tests/drivers/uart/uart_async_api/boards/mimxrt1010_evk.overlay
+++ b/tests/drivers/uart/uart_async_api/boards/mimxrt1010_evk.overlay
@@ -1,11 +1,5 @@
 /* SPDX-License-Identifier: Apache-2.0 */
 
-/ {
-	chosen {
-		zephyr,sram = &dtcm;
-	};
-};
-
 dut: &lpuart4 {
 	status = "okay";
 	current-speed = <115200>;
diff --git a/tests/drivers/uart/uart_async_api/boards/mimxrt1015_evk.overlay b/tests/drivers/uart/uart_async_api/boards/mimxrt1015_evk.overlay
index da52ae8d9d12c2..f82d4c29082ffd 100644
--- a/tests/drivers/uart/uart_async_api/boards/mimxrt1015_evk.overlay
+++ b/tests/drivers/uart/uart_async_api/boards/mimxrt1015_evk.overlay
@@ -1,11 +1,5 @@
 /* SPDX-License-Identifier: Apache-2.0 */
 
-/ {
-	chosen {
-		zephyr,sram = &dtcm;
-	};
-};
-
 dut: &lpuart4 {
 	status = "okay";
 	current-speed = <115200>;
diff --git a/tests/drivers/uart/uart_async_api/boards/mimxrt1020_evk.overlay b/tests/drivers/uart/uart_async_api/boards/mimxrt1020_evk.overlay
index cceca9150179ec..4f031193d15229 100644
--- a/tests/drivers/uart/uart_async_api/boards/mimxrt1020_evk.overlay
+++ b/tests/drivers/uart/uart_async_api/boards/mimxrt1020_evk.overlay
@@ -1,11 +1,5 @@
 /* SPDX-License-Identifier: Apache-2.0 */
 
-/ {
-	chosen {
-		zephyr,sram = &dtcm;
-	};
-};
-
 dut: &lpuart2 {
 	status = "okay";
 	current-speed = <115200>;
diff --git a/tests/drivers/uart/uart_async_api/boards/mimxrt1024_evk.overlay b/tests/drivers/uart/uart_async_api/boards/mimxrt1024_evk.overlay
index b8b4e96bc15d84..3349704181a00d 100644
--- a/tests/drivers/uart/uart_async_api/boards/mimxrt1024_evk.overlay
+++ b/tests/drivers/uart/uart_async_api/boards/mimxrt1024_evk.overlay
@@ -1,11 +1,5 @@
 /* SPDX-License-Identifier: Apache-2.0 */
 
-/ {
-	chosen {
-		zephyr,sram = &dtcm;
-	};
-};
-
 dut: &lpuart2 {
 	status = "okay";
 	current-speed = <115200>;
diff --git a/tests/drivers/uart/uart_async_api/boards/mimxrt1050_evk.overlay b/tests/drivers/uart/uart_async_api/boards/mimxrt1050_evk.overlay
index 1a0c35e198aa76..22ecfdfa712aea 100644
--- a/tests/drivers/uart/uart_async_api/boards/mimxrt1050_evk.overlay
+++ b/tests/drivers/uart/uart_async_api/boards/mimxrt1050_evk.overlay
@@ -1,11 +1,5 @@
 /* SPDX-License-Identifier: Apache-2.0 */
 
-/ {
-	chosen {
-		zephyr,sram = &dtcm;
-	};
-};
-
 dut: &lpuart3 {
 	status = "okay";
 	current-speed = <115200>;
diff --git a/tests/drivers/uart/uart_async_api/boards/mimxrt1060_evk.overlay b/tests/drivers/uart/uart_async_api/boards/mimxrt1060_evk.overlay
index 1a0c35e198aa76..22ecfdfa712aea 100644
--- a/tests/drivers/uart/uart_async_api/boards/mimxrt1060_evk.overlay
+++ b/tests/drivers/uart/uart_async_api/boards/mimxrt1060_evk.overlay
@@ -1,11 +1,5 @@
 /* SPDX-License-Identifier: Apache-2.0 */
 
-/ {
-	chosen {
-		zephyr,sram = &dtcm;
-	};
-};
-
 dut: &lpuart3 {
 	status = "okay";
 	current-speed = <115200>;
diff --git a/tests/drivers/uart/uart_async_api/boards/mimxrt1060_evkb.overlay b/tests/drivers/uart/uart_async_api/boards/mimxrt1060_evkb.overlay
index 1a0c35e198aa76..22ecfdfa712aea 100644
--- a/tests/drivers/uart/uart_async_api/boards/mimxrt1060_evkb.overlay
+++ b/tests/drivers/uart/uart_async_api/boards/mimxrt1060_evkb.overlay
@@ -1,11 +1,5 @@
 /* SPDX-License-Identifier: Apache-2.0 */
 
-/ {
-	chosen {
-		zephyr,sram = &dtcm;
-	};
-};
-
 dut: &lpuart3 {
 	status = "okay";
 	current-speed = <115200>;
diff --git a/tests/drivers/uart/uart_async_api/boards/mimxrt1064_evk.overlay b/tests/drivers/uart/uart_async_api/boards/mimxrt1064_evk.overlay
index 1a0c35e198aa76..22ecfdfa712aea 100644
--- a/tests/drivers/uart/uart_async_api/boards/mimxrt1064_evk.overlay
+++ b/tests/drivers/uart/uart_async_api/boards/mimxrt1064_evk.overlay
@@ -1,11 +1,5 @@
 /* SPDX-License-Identifier: Apache-2.0 */
 
-/ {
-	chosen {
-		zephyr,sram = &dtcm;
-	};
-};
-
 dut: &lpuart3 {
 	status = "okay";
 	current-speed = <115200>;
diff --git a/tests/drivers/uart/uart_async_api/boards/mimxrt1160_evk_mimxrt1166_cm7.overlay b/tests/drivers/uart/uart_async_api/boards/mimxrt1160_evk_mimxrt1166_cm7.overlay
index cceca9150179ec..4f031193d15229 100644
--- a/tests/drivers/uart/uart_async_api/boards/mimxrt1160_evk_mimxrt1166_cm7.overlay
+++ b/tests/drivers/uart/uart_async_api/boards/mimxrt1160_evk_mimxrt1166_cm7.overlay
@@ -1,11 +1,5 @@
 /* SPDX-License-Identifier: Apache-2.0 */
 
-/ {
-	chosen {
-		zephyr,sram = &dtcm;
-	};
-};
-
 dut: &lpuart2 {
 	status = "okay";
 	current-speed = <115200>;
diff --git a/tests/drivers/uart/uart_async_api/boards/mimxrt1170_evk_mimxrt1176_cm7_A.overlay b/tests/drivers/uart/uart_async_api/boards/mimxrt1170_evk_mimxrt1176_cm7_A.overlay
index cceca9150179ec..4f031193d15229 100644
--- a/tests/drivers/uart/uart_async_api/boards/mimxrt1170_evk_mimxrt1176_cm7_A.overlay
+++ b/tests/drivers/uart/uart_async_api/boards/mimxrt1170_evk_mimxrt1176_cm7_A.overlay
@@ -1,11 +1,5 @@
 /* SPDX-License-Identifier: Apache-2.0 */
 
-/ {
-	chosen {
-		zephyr,sram = &dtcm;
-	};
-};
-
 dut: &lpuart2 {
 	status = "okay";
 	current-speed = <115200>;
diff --git a/tests/drivers/uart/uart_async_api/testcase.yaml b/tests/drivers/uart/uart_async_api/testcase.yaml
index e7a970d4a58abe..91ef347af34250 100644
--- a/tests/drivers/uart/uart_async_api/testcase.yaml
+++ b/tests/drivers/uart/uart_async_api/testcase.yaml
@@ -58,9 +58,17 @@ tests:
     integration_platforms:
       - qemu_cortex_m0
   drivers.uart.async_api.lpuart:
-    filter: CONFIG_SERIAL_SUPPORT_ASYNC and CONFIG_UART_MCUX_LPUART
+    filter: CONFIG_SERIAL_SUPPORT_ASYNC and CONFIG_UART_MCUX_LPUART and not CONFIG_CPU_HAS_DCACHE
     harness: ztest
     depends_on: dma
+  drivers.uart.async_api.lpuart.rt_nocache:
+    filter: CONFIG_SERIAL_SUPPORT_ASYNC and CONFIG_UART_MCUX_LPUART and CONFIG_CPU_HAS_DCACHE
+    harness: ztest
+    depends_on: dma
+    extra_configs:
+      - CONFIG_DCACHE=y
+      - CONFIG_NOCACHE_MEMORY=y
+      - CONFIG_USERSPACE=n
   drivers.uart.async_api.sam0:
     filter: CONFIG_SERIAL_SUPPORT_ASYNC and CONFIG_SOC_FAMILY_ATMEL_SAM0
     platform_allow: