diff --git a/changelog/change_string_include_handle_not_match.md b/changelog/change_string_include_handle_not_match.md
new file mode 100644
index 0000000000..11cf0c2eae
--- /dev/null
+++ b/changelog/change_string_include_handle_not_match.md
@@ -0,0 +1 @@
+* [#318](https://github.com/rubocop/rubocop-performance/issues/318): Extend `Performance/StringInclude` to handle `!~`. ([@fatkodima][])
diff --git a/lib/rubocop/cop/performance/string_include.rb b/lib/rubocop/cop/performance/string_include.rb
index c3d8dcf30a..162708c172 100644
--- a/lib/rubocop/cop/performance/string_include.rb
+++ b/lib/rubocop/cop/performance/string_include.rb
@@ -22,11 +22,11 @@ module Performance
       class StringInclude < Base
         extend AutoCorrector
 
-        MSG = 'Use `String#include?` instead of a regex match with literal-only pattern.'
-        RESTRICT_ON_SEND = %i[match =~ match?].freeze
+        MSG = 'Use `%<negation>sString#include?` instead of a regex match with literal-only pattern.'
+        RESTRICT_ON_SEND = %i[match =~ !~ match?].freeze
 
         def_node_matcher :redundant_regex?, <<~PATTERN
-          {(send $!nil? {:match :=~ :match?} (regexp (str $#literal?) (regopt)))
+          {(send $!nil? {:match :=~ :!~ :match?} (regexp (str $#literal?) (regopt)))
            (send (regexp (str $#literal?) (regopt)) {:match :match?} $str)
            (match-with-lvasgn (regexp (str $#literal?) (regopt)) $_)}
         PATTERN
@@ -34,11 +34,14 @@ class StringInclude < Base
         def on_send(node)
           return unless (receiver, regex_str = redundant_regex?(node))
 
-          add_offense(node) do |corrector|
+          negation = node.send_type? && node.method?(:!~)
+          message = format(MSG, negation: ('!' if negation))
+
+          add_offense(node, message: message) do |corrector|
             receiver, regex_str = regex_str, receiver if receiver.is_a?(String)
             regex_str = interpret_string_escapes(regex_str)
 
-            new_source = "#{receiver.source}.include?(#{to_string_literal(regex_str)})"
+            new_source = "#{'!' if negation}#{receiver.source}.include?(#{to_string_literal(regex_str)})"
 
             corrector.replace(node.source_range, new_source)
           end
diff --git a/spec/rubocop/cop/performance/string_include_spec.rb b/spec/rubocop/cop/performance/string_include_spec.rb
index 1ca5ada505..f3c5946452 100644
--- a/spec/rubocop/cop/performance/string_include_spec.rb
+++ b/spec/rubocop/cop/performance/string_include_spec.rb
@@ -157,4 +157,15 @@
   it 'allows argument of `match?` is not a string literal' do
     expect_no_offenses('/ /.match?(content_as_symbol)')
   end
+
+  it 'registers an offense and corrects when using `!~`' do
+    expect_offense(<<~RUBY)
+      str !~ /abc/
+      ^^^^^^^^^^^^ Use `!String#include?` instead of a regex match with literal-only pattern.
+    RUBY
+
+    expect_correction(<<~RUBY)
+      !str.include?('abc')
+    RUBY
+  end
 end