diff --git a/compiler/rustc_target/src/asm/avr.rs b/compiler/rustc_target/src/asm/avr.rs
index 276f376b297e6..55d393c81d3ec 100644
--- a/compiler/rustc_target/src/asm/avr.rs
+++ b/compiler/rustc_target/src/asm/avr.rs
@@ -105,7 +105,12 @@ def_regs! {
         #error = ["SP", "SPL", "SPH"] =>
             "the stack pointer cannot be used as an operand for inline asm",
         #error = ["r0", "r1", "r1r0"] =>
-            "r0 and r1 are not available due to an issue in LLVM",
+            "LLVM reserves r0 (scratch register) and r1 (zero register)",
+            // If this changes within LLVM, the compiler might use the registers
+            // in the future. This must be reflected in the set of clobbered
+            // registers, else the clobber ABI implementation is *unsound*, as
+            // this generates invalid code (register is not marked as clobbered
+            // but may change the register content).
     }
 }
 
diff --git a/compiler/rustc_target/src/asm/mod.rs b/compiler/rustc_target/src/asm/mod.rs
index 9fe733e063cf5..204d5d5336102 100644
--- a/compiler/rustc_target/src/asm/mod.rs
+++ b/compiler/rustc_target/src/asm/mod.rs
@@ -928,6 +928,7 @@ pub enum InlineAsmClobberAbi {
     AArch64,
     AArch64NoX18,
     Arm64EC,
+    Avr,
     RiscV,
     RiscVE,
     LoongArch,
@@ -986,6 +987,10 @@ impl InlineAsmClobberAbi {
                 }),
                 _ => Err(&["C", "system", "efiapi"]),
             },
+            InlineAsmArch::Avr => match name {
+                "C" | "system" => Ok(InlineAsmClobberAbi::Avr),
+                _ => Err(&["C", "system"]),
+            },
             InlineAsmArch::LoongArch64 => match name {
                 "C" | "system" => Ok(InlineAsmClobberAbi::LoongArch),
                 _ => Err(&["C", "system"]),
@@ -1133,6 +1138,23 @@ impl InlineAsmClobberAbi {
                     d24, d25, d26, d27, d28, d29, d30, d31,
                 }
             },
+            InlineAsmClobberAbi::Avr => clobbered_regs! {
+                Avr AvrInlineAsmReg {
+                    // The list of "Call-Used Registers" according to
+                    // https://gcc.gnu.org/wiki/avr-gcc#Call-Used_Registers
+
+                    // Clobbered registers available in inline assembly
+                    r18, r19, r20, r21, r22, r23, r24, r25, r26, r27, r30, r31,
+                    // As per the AVR-GCC-ABI documentation linked above, the R0
+                    // register is a clobbered register as well. Since we don't
+                    // allow the usage of R0 in inline assembly, nothing has to
+                    // be done here.
+                    // Likewise, the T-flag in the SREG should be clobbered, but
+                    // this is not necessary to be listed here, since the SREG
+                    // is considered clobbered anyways unless `preserve_flags`
+                    // is used.
+                }
+            },
             InlineAsmClobberAbi::RiscV => clobbered_regs! {
                 RiscV RiscVInlineAsmReg {
                     // ra
diff --git a/tests/codegen/asm/avr-clobbers.rs b/tests/codegen/asm/avr-clobbers.rs
new file mode 100644
index 0000000000000..6e0c75368e23f
--- /dev/null
+++ b/tests/codegen/asm/avr-clobbers.rs
@@ -0,0 +1,43 @@
+//@ assembly-output: emit-asm
+//@ compile-flags: --target avr-unknown-gnu-atmega328
+//@ needs-llvm-components: avr
+
+#![crate_type = "rlib"]
+#![feature(no_core, rustc_attrs, lang_items, asm_experimental_arch)]
+#![no_core]
+
+#[lang = "sized"]
+trait Sized {}
+
+#[rustc_builtin_macro]
+macro_rules! asm {
+    () => {};
+}
+
+// CHECK-LABEL: @sreg_is_clobbered
+// CHECK: void asm sideeffect "", "~{sreg}"()
+#[no_mangle]
+pub unsafe fn sreg_is_clobbered() {
+    asm!("", options(nostack, nomem));
+}
+
+// CHECK-LABEL: @sreg_is_not_clobbered_if_preserve_flags_is_used
+// CHECK: void asm sideeffect "", ""()
+#[no_mangle]
+pub unsafe fn sreg_is_not_clobbered_if_preserve_flags_is_used() {
+    asm!("", options(nostack, nomem, preserves_flags));
+}
+
+// CHECK-LABEL: @clobber_abi
+// CHECK: asm sideeffect "", "={r18},={r19},={r20},={r21},={r22},={r23},={r24},={r25},={r26},={r27},={r30},={r31},~{sreg}"()
+#[no_mangle]
+pub unsafe fn clobber_abi() {
+    asm!("", clobber_abi("C"), options(nostack, nomem));
+}
+
+// CHECK-LABEL: @clobber_abi_with_preserved_flags
+// CHECK: asm sideeffect "", "={r18},={r19},={r20},={r21},={r22},={r23},={r24},={r25},={r26},={r27},={r30},={r31}"()
+#[no_mangle]
+pub unsafe fn clobber_abi_with_preserved_flags() {
+    asm!("", clobber_abi("C"), options(nostack, nomem, preserves_flags));
+}