diff --git a/.taskcluster.yml b/.taskcluster.yml
index 1c80e40..839cf32 100644
--- a/.taskcluster.yml
+++ b/.taskcluster.yml
@@ -14,18 +14,28 @@ tasks:
     environments:
       - image: node:6
         description: Run tests with node v6
+        command: npm test
       - image: node:8
         description: Run tests with node v8
+        command: npm test
       - image: node:10
         description: Run tests with node v10
+        command: npm test
       - image: node:12
         description: Run tests with node v12
+        command: npm test
       - image: node:14
         description: Run tests with node v14
+        command: npm test
       - image: node:16
         description: Run tests with node v16
+        command: npm test
       - image: node:latest
         description: Run tests with latest node
+        command: npm test
+      - image: node:latest
+        description: Run tests with latest node without Buffer
+        command: npm run test-nobuffer
   in:
     $if: tasks_for == "github-pull-request" && event["action"] in ["opened","reopened","synchronize"]
     then:
@@ -57,4 +67,4 @@ tasks:
               git config advice.detachedHead false &&
               git checkout --no-progress ${head_rev} &&
               npm install --no-progress . &&
-              npm test
+              ${env.command}
diff --git a/package.json b/package.json
index ac10519..b1683a7 100644
--- a/package.json
+++ b/package.json
@@ -5,7 +5,8 @@
   "description": "URL-safe base64 UUID encoder for generating 22 character slugs",
   "license": "MIT",
   "scripts": {
-    "test": "nodeunit slugid_test.js"
+    "test": "nodeunit slugid_test.js",
+    "test-nobuffer": "NO_BUFFER=1 npm test"
   },
   "repository": {
     "type": "git",
diff --git a/slugid.js b/slugid.js
index 5d1d69f..e90ceee 100644
--- a/slugid.js
+++ b/slugid.js
@@ -22,13 +22,29 @@
 
 var uuid = require('uuid');
 
+/** @type {(bytes: Uint8Array) => string} */
+var toBase64 = (() => {
+  if (typeof Buffer !== 'undefined') {
+    return (bytes) => Buffer.from(bytes).toString('base64');
+  }
+  return (bytes) => btoa(String.fromCharCode(...bytes));
+})();
+
+/** @type {(base64: string) => Uint8Array | Buffer} */
+var fromBase64 = (() => {
+  if (typeof Buffer !== 'undefined') {
+    return (base64) => Buffer.from(base64, 'base64');
+  }
+  return (base64) => Uint8Array.from(atob(base64), c => c.charCodeAt(0));
+})();
+
 /**
  * Returns the given uuid as a 22 character slug. This can be a regular v4
  * slug or a "nice" slug.
  */
 exports.encode = function(uuid_) {
   var bytes   = uuid.parse(uuid_);
-  var base64  = Buffer.from(bytes).toString('base64');
+  var base64 = toBase64(bytes);
   var slug = base64
               .replace(/\+/g, '-')  // Replace + with - (see RFC 4648, sec. 5)
               .replace(/\//g, '_')  // Replace / with _ (see RFC 4648, sec. 5)
@@ -44,15 +60,15 @@ exports.decode = function(slug) {
                   .replace(/-/g, '+')
                   .replace(/_/g, '/')
                   + '==';
-  return uuid.stringify(Buffer.from(base64, 'base64'));
+  return uuid.stringify(fromBase64(base64));
 };
 
 /**
  * Returns a randomly generated uuid v4 compliant slug
  */
 exports.v4 = function() {
-  var bytes   = uuid.v4(null, Buffer.alloc(16));
-  var base64  = bytes.toString('base64');
+  var bytes   = uuid.v4(null, new Uint8Array(16));
+  var base64 = toBase64(bytes);
   var slug = base64
               .replace(/\+/g, '-')  // Replace + with - (see RFC 4648, sec. 5)
               .replace(/\//g, '_')  // Replace / with _ (see RFC 4648, sec. 5)
@@ -72,9 +88,9 @@ exports.v4 = function() {
  * restrict the range of potential uuids that may be generated.
  */
 exports.nice = function() {
-  var bytes   = uuid.v4(null, Buffer.alloc(16));
+  var bytes   = uuid.v4(null, new Uint8Array(16));
   bytes[0] = bytes[0] & 0x7f;  // unset first bit to ensure [A-Za-f] first char
-  var base64  = bytes.toString('base64');
+  var base64 = toBase64(bytes);
   var slug = base64
               .replace(/\+/g, '-')  // Replace + with - (see RFC 4648, sec. 5)
               .replace(/\//g, '_')  // Replace / with _ (see RFC 4648, sec. 5)
diff --git a/slugid_test.js b/slugid_test.js
index 00ae745..c555af7 100644
--- a/slugid_test.js
+++ b/slugid_test.js
@@ -20,6 +20,12 @@
 // OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
 // THE SOFTWARE.
 
+// Allows the tests to be run in environments with and without `Buffer`.
+if (process.env.NO_BUFFER === "1") {
+  delete global.Buffer;
+  console.log('\x1b[33m' + 'Removed `Buffer` from globalThis.' + '\x1b[0m');
+}
+
 var slugid = require('./slugid');
 var uuidv4 = require('uuid').v4;