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Ensure it is trivial to do GSEM with umxRAM #146

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tbates opened this issue Dec 23, 2020 · 1 comment
Open

Ensure it is trivial to do GSEM with umxRAM #146

tbates opened this issue Dec 23, 2020 · 1 comment

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@tbates
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tbates commented Dec 23, 2020

Consider wrappers for the GWAS pipeline also.
https://github.com/MichelNivard/GenomicSEM/wiki

@mcneale
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mcneale commented Dec 23, 2020

Yes, there are some weirdnesses with Lavaan or OpenMx WLS(MV) implementations that make them disagree. Others have reported inconsistencies between Lavaan and MPlus. At least we can triangulate a bit - and with two of them being open source we can actually figure out WHY they differ if they do.

For more complicated modeling, OpenMx will be faster than Lavaan due to using C++ instead of R for computation & optimization. However, for WLS, where the weight matrix has to be inverted only once, most of the heavy lifting has already been done, with WLS model-fitting proceeding very rapidly.

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