diff --git a/tokio/src/sync/mpsc/chan.rs b/tokio/src/sync/mpsc/chan.rs
index 6f87715dd34..f24bb03fb4f 100644
--- a/tokio/src/sync/mpsc/chan.rs
+++ b/tokio/src/sync/mpsc/chan.rs
@@ -6,6 +6,7 @@ use crate::runtime::park::CachedParkThread;
 use crate::sync::mpsc::error::TryRecvError;
 use crate::sync::mpsc::{bounded, list, unbounded};
 use crate::sync::notify::Notify;
+use crate::util::cacheline::CachePadded;
 
 use std::fmt;
 use std::process;
@@ -46,18 +47,18 @@ pub(crate) trait Semaphore {
 }
 
 pub(super) struct Chan<T, S> {
+    /// Handle to the push half of the lock-free list.
+    tx: CachePadded<list::Tx<T>>,
+
+    /// Receiver waker. Notified when a value is pushed into the channel.
+    rx_waker: CachePadded<AtomicWaker>,
+
     /// Notifies all tasks listening for the receiver being dropped.
     notify_rx_closed: Notify,
 
-    /// Handle to the push half of the lock-free list.
-    tx: list::Tx<T>,
-
     /// Coordinates access to channel's capacity.
     semaphore: S,
 
-    /// Receiver waker. Notified when a value is pushed into the channel.
-    rx_waker: AtomicWaker,
-
     /// Tracks the number of outstanding sender handles.
     ///
     /// When this drops to zero, the send half of the channel is closed.
@@ -73,9 +74,9 @@ where
 {
     fn fmt(&self, fmt: &mut fmt::Formatter<'_>) -> fmt::Result {
         fmt.debug_struct("Chan")
-            .field("tx", &self.tx)
+            .field("tx", &*self.tx)
             .field("semaphore", &self.semaphore)
-            .field("rx_waker", &self.rx_waker)
+            .field("rx_waker", &*self.rx_waker)
             .field("tx_count", &self.tx_count)
             .field("rx_fields", &"...")
             .finish()
@@ -108,9 +109,9 @@ pub(crate) fn channel<T, S: Semaphore>(semaphore: S) -> (Tx<T, S>, Rx<T, S>) {
 
     let chan = Arc::new(Chan {
         notify_rx_closed: Notify::new(),
-        tx,
+        tx: CachePadded::new(tx),
         semaphore,
-        rx_waker: AtomicWaker::new(),
+        rx_waker: CachePadded::new(AtomicWaker::new()),
         tx_count: AtomicUsize::new(1),
         rx_fields: UnsafeCell::new(RxFields {
             list: rx,
diff --git a/tokio/src/util/cacheline.rs b/tokio/src/util/cacheline.rs
new file mode 100644
index 00000000000..64fd5ccad33
--- /dev/null
+++ b/tokio/src/util/cacheline.rs
@@ -0,0 +1,95 @@
+#![cfg_attr(not(feature = "sync"), allow(dead_code, unreachable_pub))]
+use std::ops::{Deref, DerefMut};
+
+/// Pads and aligns a value to the length of a cache line.
+#[derive(Clone, Copy, Default, Hash, PartialEq, Eq)]
+// Starting from Intel's Sandy Bridge, spatial prefetcher is now pulling pairs of 64-byte cache
+// lines at a time, so we have to align to 128 bytes rather than 64.
+//
+// Sources:
+// - https://www.intel.com/content/dam/www/public/us/en/documents/manuals/64-ia-32-architectures-optimization-manual.pdf
+// - https://github.com/facebook/folly/blob/1b5288e6eea6df074758f877c849b6e73bbb9fbb/folly/lang/Align.h#L107
+//
+// ARM's big.LITTLE architecture has asymmetric cores and "big" cores have 128-byte cache line size.
+//
+// Sources:
+// - https://www.mono-project.com/news/2016/09/12/arm64-icache/
+//
+// powerpc64 has 128-byte cache line size.
+//
+// Sources:
+// - https://github.com/golang/go/blob/3dd58676054223962cd915bb0934d1f9f489d4d2/src/internal/cpu/cpu_ppc64x.go#L9
+#[cfg_attr(
+    any(
+        target_arch = "x86_64",
+        target_arch = "aarch64",
+        target_arch = "powerpc64",
+    ),
+    repr(align(128))
+)]
+// arm, mips, mips64, and riscv64 have 32-byte cache line size.
+//
+// Sources:
+// - https://github.com/golang/go/blob/3dd58676054223962cd915bb0934d1f9f489d4d2/src/internal/cpu/cpu_arm.go#L7
+// - https://github.com/golang/go/blob/3dd58676054223962cd915bb0934d1f9f489d4d2/src/internal/cpu/cpu_mips.go#L7
+// - https://github.com/golang/go/blob/3dd58676054223962cd915bb0934d1f9f489d4d2/src/internal/cpu/cpu_mipsle.go#L7
+// - https://github.com/golang/go/blob/3dd58676054223962cd915bb0934d1f9f489d4d2/src/internal/cpu/cpu_mips64x.go#L9
+// - https://github.com/golang/go/blob/3dd58676054223962cd915bb0934d1f9f489d4d2/src/internal/cpu/cpu_riscv64.go#L7
+#[cfg_attr(
+    any(
+        target_arch = "arm",
+        target_arch = "mips",
+        target_arch = "mips64",
+        target_arch = "riscv64",
+    ),
+    repr(align(32))
+)]
+// s390x has 256-byte cache line size.
+//
+// Sources:
+// - https://github.com/golang/go/blob/3dd58676054223962cd915bb0934d1f9f489d4d2/src/internal/cpu/cpu_s390x.go#L7
+#[cfg_attr(target_arch = "s390x", repr(align(256)))]
+// x86 and wasm have 64-byte cache line size.
+//
+// Sources:
+// - https://github.com/golang/go/blob/dda2991c2ea0c5914714469c4defc2562a907230/src/internal/cpu/cpu_x86.go#L9
+// - https://github.com/golang/go/blob/3dd58676054223962cd915bb0934d1f9f489d4d2/src/internal/cpu/cpu_wasm.go#L7
+//
+// All others are assumed to have 64-byte cache line size.
+#[cfg_attr(
+    not(any(
+        target_arch = "x86_64",
+        target_arch = "aarch64",
+        target_arch = "powerpc64",
+        target_arch = "arm",
+        target_arch = "mips",
+        target_arch = "mips64",
+        target_arch = "riscv64",
+        target_arch = "s390x",
+    )),
+    repr(align(64))
+)]
+pub(crate) struct CachePadded<T> {
+    value: T,
+}
+
+impl<T> CachePadded<T> {
+    /// Pads and aligns a value to the length of a cache line.
+    pub(crate) fn new(value: T) -> CachePadded<T> {
+        CachePadded::<T> { value }
+    }
+}
+
+impl<T> Deref for CachePadded<T> {
+    type Target = T;
+
+    fn deref(&self) -> &T {
+        &self.value
+    }
+}
+
+impl<T> DerefMut for CachePadded<T> {
+    fn deref_mut(&mut self) -> &mut T {
+        &mut self.value
+    }
+}
diff --git a/tokio/src/util/mod.rs b/tokio/src/util/mod.rs
index dc997f4e67a..7d4cd5f9c7c 100644
--- a/tokio/src/util/mod.rs
+++ b/tokio/src/util/mod.rs
@@ -75,3 +75,5 @@ pub(crate) mod error;
 pub(crate) mod memchr;
 
 pub(crate) mod markers;
+
+pub(crate) mod cacheline;