template-matching drug-repurposing bootstrapping-statistics hungarian-algorithm blob-detection permutation-test kolmogorov-smirnov-tests single-cell-analysis scale-space-filtering tubulin-inhibitors von-hippel-lindau-disease kidney-cancer retinal-pigment-epithelium intensity-histogram-thresholding difference-of-gaussians histone-deacetylase-inhibitor-trichostatin-a nocodazole paclitaxel cytoplasmic-linker-protein-170 glycogen-synthase-kinase-3-beta