diff --git a/build/pkgs/gast/checksums.ini b/build/pkgs/gast/checksums.ini
index e4992447b2b..1aa653229f2 100644
--- a/build/pkgs/gast/checksums.ini
+++ b/build/pkgs/gast/checksums.ini
@@ -1,5 +1,5 @@
 tarball=gast-VERSION.tar.gz
-sha1=99491544f561ef76523e6f29a621ce633fc7a1c1
-md5=eb2489df0c85ae198e4740e5711c7299
-cksum=307283150
+sha1=a84811eedebc5bca94b4eae978aab5f2c805b106
+md5=fdff900805e03e9dd76d377eb4cbaed7
+cksum=387443419
 upstream_url=https://pypi.io/packages/source/g/gast/gast-VERSION.tar.gz
diff --git a/build/pkgs/gast/package-version.txt b/build/pkgs/gast/package-version.txt
index cb0c939a936..be14282b7ff 100644
--- a/build/pkgs/gast/package-version.txt
+++ b/build/pkgs/gast/package-version.txt
@@ -1 +1 @@
-0.5.2
+0.5.3
diff --git a/build/pkgs/networkx/checksums.ini b/build/pkgs/networkx/checksums.ini
index 075e0c74047..fd005a4d478 100644
--- a/build/pkgs/networkx/checksums.ini
+++ b/build/pkgs/networkx/checksums.ini
@@ -1,5 +1,5 @@
 tarball=networkx-VERSION.tar.gz
-sha1=659f640c03fe52c98fa7a1d03fe3a6f6bbce2015
-md5=407eb28c54e08725559754ca7ab185e0
-cksum=3378468789
+sha1=757ea87972243f1dab99687cd94ed51377efa34b
+md5=91fdb77298a54c6e7cfb2d5305d23d23
+cksum=2430190254
 upstream_url=https://pypi.io/packages/source/n/networkx/networkx-VERSION.tar.gz
diff --git a/build/pkgs/networkx/package-version.txt b/build/pkgs/networkx/package-version.txt
index ec1cf33c3f6..2701a226a2f 100644
--- a/build/pkgs/networkx/package-version.txt
+++ b/build/pkgs/networkx/package-version.txt
@@ -1 +1 @@
-2.6.3
+2.8.4
diff --git a/build/pkgs/numpy/checksums.ini b/build/pkgs/numpy/checksums.ini
index f4013779be9..c15b3d8db64 100644
--- a/build/pkgs/numpy/checksums.ini
+++ b/build/pkgs/numpy/checksums.ini
@@ -1,5 +1,5 @@
 tarball=numpy-VERSION.zip
-sha1=91a1faeb617601453ebf6e2855e5ce6bf94d3588
-md5=b3c4477a027d5b6fba5e1065064fd076
-cksum=1917168823
+sha1=3ac08064b2ec8db8fe4870c2545c9d154f46bb30
+md5=b44849506fbb54cdef9dbb435b2b1987
+cksum=735479084
 upstream_url=https://pypi.io/packages/source/n/numpy/numpy-VERSION.zip
diff --git a/build/pkgs/numpy/package-version.txt b/build/pkgs/numpy/package-version.txt
index 20a1265cf39..2a0ba77cc5e 100644
--- a/build/pkgs/numpy/package-version.txt
+++ b/build/pkgs/numpy/package-version.txt
@@ -1 +1 @@
-1.21.4
+1.22.4
diff --git a/build/pkgs/numpy/patches/21891.patch b/build/pkgs/numpy/patches/21891.patch
new file mode 100644
index 00000000000..095fa894ebb
--- /dev/null
+++ b/build/pkgs/numpy/patches/21891.patch
@@ -0,0 +1,31 @@
+From c7894260aaf36c447dd091bf622c7c2bcdb15a28 Mon Sep 17 00:00:00 2001
+From: Matthias Koeppe <mkoeppe@math.ucdavis.edu>
+Date: Thu, 30 Jun 2022 13:18:46 -0700
+Subject: [PATCH] setup.py: Remove check for SETUPTOOLS_USE_DISTUTILS
+
+---
+ setup.py | 11 -----------
+ 1 file changed, 11 deletions(-)
+
+diff --git a/setup.py b/setup.py
+index 353b6c09693..2bc70173eca 100755
+--- a/setup.py
++++ b/setup.py
+@@ -85,17 +85,6 @@
+ # so that it is in sys.modules
+ import numpy.distutils.command.sdist
+ import setuptools
+-if int(setuptools.__version__.split('.')[0]) >= 60:
+-    # setuptools >= 60 switches to vendored distutils by default; this
+-    # may break the numpy build, so make sure the stdlib version is used
+-    try:
+-        setuptools_use_distutils = os.environ['SETUPTOOLS_USE_DISTUTILS']
+-    except KeyError:
+-        os.environ['SETUPTOOLS_USE_DISTUTILS'] = "stdlib"
+-    else:
+-        if setuptools_use_distutils != "stdlib":
+-            raise RuntimeError("setuptools versions >= '60.0.0' require "
+-                    "SETUPTOOLS_USE_DISTUTILS=stdlib in the environment")
+ 
+ # Initialize cmdclass from versioneer
+ from numpy.distutils.core import numpy_cmdclass
diff --git a/build/pkgs/numpy/spkg-install.in b/build/pkgs/numpy/spkg-install.in
index 1a2c77fb8a8..f66c6f56426 100644
--- a/build/pkgs/numpy/spkg-install.in
+++ b/build/pkgs/numpy/spkg-install.in
@@ -38,6 +38,16 @@ else
     export NUMPY_FCONFIG
 fi
 
+# Trac #32423: Fix 32-bit builds on x86_64
+ARCH=$($CC -dumpmachine 2>/dev/null || echo unknown)
+case "$ARCH" in
+    *x86_64*)
+        ;;
+    *)
+        export NPY_DISABLE_SVML=1
+        ;;
+esac
+
 ################################################
 
 # Trac #33138: numpy is a PEP 517 package, so the crucial "--build-option"s would be ignored.
diff --git a/build/pkgs/pybind11/checksums.ini b/build/pkgs/pybind11/checksums.ini
index f49c404fbc4..1a6fb10c749 100644
--- a/build/pkgs/pybind11/checksums.ini
+++ b/build/pkgs/pybind11/checksums.ini
@@ -1,5 +1,5 @@
 tarball=pybind11-VERSION.tar.gz
-sha1=2f15bd2037e91adc14fa1d648e6091acd114ed97
-md5=2fb29e67a2158f80d2038ba619847629
-cksum=2184277382
+sha1=cee2f3c7879783bb5f021c7db332f8a290fe3763
+md5=c232928479f398693bface2731387691
+cksum=3770559962
 upstream_url=https://pypi.io/packages/source/p/pybind11/pybind11-VERSION.tar.gz
diff --git a/build/pkgs/pybind11/package-version.txt b/build/pkgs/pybind11/package-version.txt
index dbe59006547..5d9ade10c60 100644
--- a/build/pkgs/pybind11/package-version.txt
+++ b/build/pkgs/pybind11/package-version.txt
@@ -1 +1 @@
-2.8.1
+2.9.2
diff --git a/build/pkgs/scipy/checksums.ini b/build/pkgs/scipy/checksums.ini
index 9db6d5aab7d..25b470f4624 100644
--- a/build/pkgs/scipy/checksums.ini
+++ b/build/pkgs/scipy/checksums.ini
@@ -1,5 +1,5 @@
 tarball=scipy-VERSION.tar.gz
-sha1=4667454b1ee5195b8c104a68e15ab7f9aa0570fd
-md5=daae4fedcd479738e54fd7035445be89
-cksum=2230241814
+sha1=6dfee9fe5f021409b4d294b0a7d9da05b810d207
+md5=df5ce79288fc457238aeef18e8f70dfc
+cksum=3909760197
 upstream_url=https://pypi.io/packages/source/s/scipy/scipy-VERSION.tar.gz
diff --git a/build/pkgs/scipy/package-version.txt b/build/pkgs/scipy/package-version.txt
index 661e7aeadf3..a8fdfda1c78 100644
--- a/build/pkgs/scipy/package-version.txt
+++ b/build/pkgs/scipy/package-version.txt
@@ -1 +1 @@
-1.7.3
+1.8.1