diff --git a/pkgs/development/libraries/mesa/default.nix b/pkgs/development/libraries/mesa/default.nix
index 2225019d1d54eb2..a84f8ab254848dc 100644
--- a/pkgs/development/libraries/mesa/default.nix
+++ b/pkgs/development/libraries/mesa/default.nix
@@ -253,6 +253,10 @@ self = stdenv.mkDerivation {
   NIX_CFLAGS_COMPILE = lib.optionals stdenv.isDarwin [ "-fno-common" ] ++ lib.optionals enableOpenCL [
     "-UPIPE_SEARCH_DIR"
     "-DPIPE_SEARCH_DIR=\"${placeholder "opencl"}/lib/gallium-pipe\""
+
+    # Work around regression from https://github.com/NixOS/nixpkgs/pull/210004
+    # TODO(trofi): remove
+    "--sysroot=/"
   ];
 
   passthru = {