diff --git a/icu4c/source/test/intltest/loctest.cpp b/icu4c/source/test/intltest/loctest.cpp
index 3131286abc89..f3e16d3fa0dc 100644
--- a/icu4c/source/test/intltest/loctest.cpp
+++ b/icu4c/source/test/intltest/loctest.cpp
@@ -5923,6 +5923,11 @@ testLikelySubtagsLineFn(void *context,
         return;
     }
 
+    if ((uprv_strcmp(source.c_str(), "und-Latn-RS") == 0 )
+        && THIS->logKnownIssue("ICU-22976", "unexpected likely subtags for und-Latn-RS")) {
+      return;
+    }
+
     Locale actualMax(l);
     actualMax.addLikelySubtags(*pErrorCode);
     if (addLikely == "FAIL") {