diff --git a/Cargo.lock b/Cargo.lock
index 20bec05e..31588edc 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -31,7 +31,7 @@ dependencies = [
  "actix-utils",
  "ahash",
  "base64",
- "bitflags 2.4.0",
+ "bitflags 2.4.1",
  "brotli",
  "bytes",
  "bytestring",
@@ -232,12 +232,6 @@ dependencies = [
  "alloc-no-stdlib",
 ]
 
-[[package]]
-name = "allocator-api2"
-version = "0.2.16"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "0942ffc6dcaadf03badf6e6a2d0228460359d5e34b57ccdc720b7382dfbd5ec5"
-
 [[package]]
 name = "android-tzdata"
 version = "0.1.1"
@@ -260,22 +254,22 @@ dependencies = [
  "actix-web",
  "anyhow",
  "bgzip",
+ "biocommons-bioutils",
  "boolvec",
  "byteorder",
  "chrono",
  "clap",
  "clap-verbosity-flag",
  "csv",
- "enum-map 2.6.3",
+ "enum-map",
  "env_logger",
  "flate2",
- "hgvs",
  "indexmap 2.0.2",
  "indicatif",
  "insta",
  "log",
  "noodles-bed",
- "noodles-bgzf 0.25.0",
+ "noodles-bgzf",
  "noodles-core",
  "noodles-csi",
  "noodles-tabix",
@@ -351,26 +345,6 @@ version = "1.0.75"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "a4668cab20f66d8d020e1fbc0ebe47217433c1b6c8f2040faf858554e394ace6"
 
-[[package]]
-name = "approx"
-version = "0.5.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "cab112f0a86d568ea0e627cc1d6be74a1e9cd55214684db5561995f6dad897c6"
-dependencies = [
- "num-traits",
-]
-
-[[package]]
-name = "async-trait"
-version = "0.1.73"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "bc00ceb34980c03614e35a3a4e218276a0a824e911d07651cd0d858a51e8c0f0"
-dependencies = [
- "proc-macro2",
- "quote",
- "syn 2.0.38",
-]
-
 [[package]]
 name = "autocfg"
 version = "1.1.0"
@@ -392,12 +366,6 @@ dependencies = [
  "rustc-demangle",
 ]
 
-[[package]]
-name = "base16ct"
-version = "0.2.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "4c7f02d4ea65f2c1853089ffd8d2787bdbc63de2f0d29dedbcf8ccdfa0ccd4cf"
-
 [[package]]
 name = "base64"
 version = "0.21.4"
@@ -438,65 +406,17 @@ dependencies = [
 ]
 
 [[package]]
-name = "bio"
-version = "1.4.0"
+name = "biocommons-bioutils"
+version = "0.1.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ea643e25059ce02b94e8f6eb4e902d160baa6d0beb91834ed971dd5a880c02ba"
+checksum = "82c91bd0b62cec4b6317445506ed4947a53c320942a681c5a086f4d576aa4c99"
 dependencies = [
- "anyhow",
- "approx",
- "bio-types",
- "bit-set",
- "bv",
- "bytecount",
- "csv",
- "custom_derive",
- "editdistancek",
- "enum-map 1.1.1",
- "fxhash",
- "getset",
- "itertools",
- "itertools-num",
+ "enum-map",
+ "flate2",
+ "indexmap 2.0.2",
  "lazy_static",
- "multimap",
- "ndarray",
- "newtype_derive",
- "num-integer",
- "num-traits",
- "ordered-float",
- "petgraph",
- "rand",
- "regex",
  "serde",
- "serde_derive",
- "statrs",
- "strum",
- "strum_macros",
- "thiserror",
- "triple_accel",
- "vec_map",
-]
-
-[[package]]
-name = "bio-types"
-version = "1.0.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "9d45749b87f21808051025e9bf714d14ff4627f9d8ca967eade6946ea769aa4a"
-dependencies = [
- "derive-new",
- "lazy_static",
- "regex",
- "strum_macros",
- "thiserror",
-]
-
-[[package]]
-name = "bit-set"
-version = "0.5.3"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "0700ddab506f33b20a03b13996eccd309a48e5ff77d0d95926aa0210fb4e95f1"
-dependencies = [
- "bit-vec",
+ "serde_json",
 ]
 
 [[package]]
@@ -513,9 +433,9 @@ checksum = "bef38d45163c2f1dde094a7dfd33ccf595c92905c8f8f4fdc18d06fb1037718a"
 
 [[package]]
 name = "bitflags"
-version = "2.4.0"
+version = "2.4.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "b4682ae6287fcf752ecaabbfcc7b6f9b72aa33933dc23a554d853aea8eea8635"
+checksum = "327762f6e5a765692301e5bb513e0d9fef63be86bbc14528052b1cd3e6f03e07"
 
 [[package]]
 name = "block-buffer"
@@ -559,28 +479,6 @@ version = "3.14.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "7f30e7476521f6f8af1a1c4c0b8cc94f0bee37d91763d0ca2665f299b6cd8aec"
 
-[[package]]
-name = "bv"
-version = "0.11.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "8834bb1d8ee5dc048ee3124f2c7c1afcc6bc9aed03f11e9dfd8c69470a5db340"
-dependencies = [
- "feature-probe",
- "serde",
-]
-
-[[package]]
-name = "bytecount"
-version = "0.6.4"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ad152d03a2c813c80bb94fedbf3a3f02b28f793e39e7c214c8a0bcc196343de7"
-
-[[package]]
-name = "bytemuck"
-version = "1.14.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "374d28ec25809ee0e23827c2ab573d729e293f281dfe393500e7ad618baa61c6"
-
 [[package]]
 name = "byteorder"
 version = "1.5.0"
@@ -758,9 +656,9 @@ checksum = "e496a50fda8aacccc86d7529e2c1e0892dbd0f898a6b5645b5561b89c3210efa"
 
 [[package]]
 name = "cpufeatures"
-version = "0.2.9"
+version = "0.2.10"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "a17b76ff3a4162b0b27f354a0c87015ddad39d35f9c0c36607a3bdd175dde1f1"
+checksum = "3fbc60abd742b35f2492f808e1abbb83d45f72db402e14c55057edc9c7b1e9e4"
 dependencies = [
  "libc",
 ]
@@ -848,12 +746,6 @@ dependencies = [
  "memchr",
 ]
 
-[[package]]
-name = "custom_derive"
-version = "0.1.7"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ef8ae57c4978a2acd8b869ce6b9ca1dfe817bff704c220209fdef2c0b75a01b9"
-
 [[package]]
 name = "darling"
 version = "0.20.3"
@@ -891,24 +783,14 @@ dependencies = [
 
 [[package]]
 name = "deranged"
-version = "0.3.8"
+version = "0.3.9"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f2696e8a945f658fd14dc3b87242e6b80cd0f36ff04ea560fa39082368847946"
+checksum = "0f32d04922c60427da6f9fef14d042d9edddef64cb9d4ce0d64d0685fbeb1fd3"
 dependencies = [
+ "powerfmt",
  "serde",
 ]
 
-[[package]]
-name = "derive-new"
-version = "0.5.9"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "3418329ca0ad70234b9735dc4ceed10af4df60eff9c8e7b06cb5e520d92c3535"
-dependencies = [
- "proc-macro2",
- "quote",
- "syn 1.0.109",
-]
-
 [[package]]
 name = "derive_more"
 version = "0.99.17"
@@ -918,7 +800,7 @@ dependencies = [
  "convert_case",
  "proc-macro2",
  "quote",
- "rustc_version 0.4.0",
+ "rustc_version",
  "syn 1.0.109",
 ]
 
@@ -936,15 +818,8 @@ checksum = "9ed9a281f7bc9b7576e61468ba615a66a5c8cfdff42420a70aa82701a3b1e292"
 dependencies = [
  "block-buffer",
  "crypto-common",
- "subtle",
 ]
 
-[[package]]
-name = "editdistancek"
-version = "1.0.2"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "3e02df23d5b1c6f9e69fa603b890378123b93073df998a21e6e33b9db0a32613"
-
 [[package]]
 name = "either"
 version = "1.9.0"
@@ -968,34 +843,14 @@ dependencies = [
 
 [[package]]
 name = "enum-map"
-version = "1.1.1"
+version = "2.7.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e893a7ba6116821058dec84a6fb14fb2a97cd8ce5fd0f85d5a4e760ecd7329d9"
+checksum = "53337c2dbf26a3c31eccc73a37b10c1614e8d4ae99b6a50d553e8936423c1f16"
 dependencies = [
- "enum-map-derive 0.6.0",
-]
-
-[[package]]
-name = "enum-map"
-version = "2.6.3"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "c188012f8542dee7b3996e44dd89461d64aa471b0a7c71a1ae2f595d259e96e5"
-dependencies = [
- "enum-map-derive 0.14.0",
+ "enum-map-derive",
  "serde",
 ]
 
-[[package]]
-name = "enum-map-derive"
-version = "0.6.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "84278eae0af6e34ff6c1db44c11634a694aafac559ff3080e4db4e4ac35907aa"
-dependencies = [
- "proc-macro2",
- "quote",
- "syn 1.0.109",
-]
-
 [[package]]
 name = "enum-map-derive"
 version = "0.14.0"
@@ -1036,36 +891,12 @@ dependencies = [
  "windows-sys 0.48.0",
 ]
 
-[[package]]
-name = "fallible-iterator"
-version = "0.2.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "4443176a9f2c162692bd3d352d745ef9413eec5782a80d8fd6f8a1ac692a07f7"
-
-[[package]]
-name = "fallible-streaming-iterator"
-version = "0.1.9"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7360491ce676a36bf9bb3c56c1aa791658183a54d2744120f27285738d90465a"
-
 [[package]]
 name = "fastrand"
 version = "2.0.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "25cbce373ec4653f1a01a31e8a5e5ec0c622dc27ff9c4e6606eefef5cbbed4a5"
 
-[[package]]
-name = "feature-probe"
-version = "0.1.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "835a3dc7d1ec9e75e2b5fb4ba75396837112d2060b03f7d43bc1897c7f7211da"
-
-[[package]]
-name = "finl_unicode"
-version = "1.2.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "8fcfdc7a0362c9f4444381a9e697c79d435fe65b52a37466fc2c1184cee9edc6"
-
 [[package]]
 name = "fixedbitset"
 version = "0.4.2"
@@ -1097,33 +928,12 @@ dependencies = [
  "percent-encoding",
 ]
 
-[[package]]
-name = "futures-channel"
-version = "0.3.28"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "955518d47e09b25bbebc7a18df10b81f0c766eaf4c4f1cccef2fca5f2a4fb5f2"
-dependencies = [
- "futures-core",
- "futures-sink",
-]
-
 [[package]]
 name = "futures-core"
 version = "0.3.28"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "4bca583b7e26f571124fe5b7561d49cb2868d79116cfa0eefce955557c6fee8c"
 
-[[package]]
-name = "futures-macro"
-version = "0.3.28"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "89ca545a94061b6365f2c7355b4b32bd20df3ff95f02da9329b34ccc3bd6ee72"
-dependencies = [
- "proc-macro2",
- "quote",
- "syn 2.0.38",
-]
-
 [[package]]
 name = "futures-sink"
 version = "0.3.28"
@@ -1143,21 +953,9 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "26b01e40b772d54cf6c6d721c1d1abd0647a0106a12ecaa1c186273392a69533"
 dependencies = [
  "futures-core",
- "futures-macro",
- "futures-sink",
  "futures-task",
  "pin-project-lite",
  "pin-utils",
- "slab",
-]
-
-[[package]]
-name = "fxhash"
-version = "0.2.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "c31b6d751ae2c7f11320402d34e41349dd1016f8d5d45e48c4312bc8625af50c"
-dependencies = [
- "byteorder",
 ]
 
 [[package]]
@@ -1181,18 +979,6 @@ dependencies = [
  "wasi",
 ]
 
-[[package]]
-name = "getset"
-version = "0.1.2"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e45727250e75cc04ff2846a66397da8ef2b3db8e40e0cef4df67950a07621eb9"
-dependencies = [
- "proc-macro-error",
- "proc-macro2",
- "quote",
- "syn 1.0.109",
-]
-
 [[package]]
 name = "gimli"
 version = "0.28.0"
@@ -1232,22 +1018,9 @@ checksum = "8a9ee70c43aaf417c914396645a0fa852624801b24ebb7ae78fe8272889ac888"
 
 [[package]]
 name = "hashbrown"
-version = "0.14.1"
+version = "0.14.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7dfda62a12f55daeae5015f81b0baea145391cb4520f86c248fc615d72640d12"
-dependencies = [
- "ahash",
- "allocator-api2",
-]
-
-[[package]]
-name = "hashlink"
-version = "0.8.4"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e8094feaf31ff591f651a2664fb9cfd92bba7a60ce3197265e9482ebe753c8f7"
-dependencies = [
- "hashbrown 0.14.1",
-]
+checksum = "f93e7192158dbcda357bdec5fb5788eebf8bbac027f3f33e719d29135ae84156"
 
 [[package]]
 name = "heck"
@@ -1267,41 +1040,6 @@ version = "0.4.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "7f24254aa9a54b5c858eaee2f5bccdb46aaf0e486a595ed5fd8f86ba55232a70"
 
-[[package]]
-name = "hgvs"
-version = "0.11.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d2c8237412c585364c6d56a985ea67f550a2e8fd55c6b8f949e732a89d2274a7"
-dependencies = [
- "base16ct",
- "bio",
- "chrono",
- "enum-map 2.6.3",
- "flate2",
- "indexmap 2.0.2",
- "lazy_static",
- "log",
- "md-5",
- "nom",
- "postgres",
- "quick_cache",
- "regex",
- "rustc-hash",
- "seqrepo",
- "serde",
- "serde_json",
- "thiserror",
-]
-
-[[package]]
-name = "hmac"
-version = "0.12.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "6c49c37c09c17a53d937dfbb742eb3a961d65a994e6bcdcf37e7399d0cc8ab5e"
-dependencies = [
- "digest",
-]
-
 [[package]]
 name = "home"
 version = "0.5.5"
@@ -1342,16 +1080,16 @@ checksum = "9a3a5bfb195931eeb336b2a7b4d761daec841b97f947d34394601737a7bba5e4"
 
 [[package]]
 name = "iana-time-zone"
-version = "0.1.57"
+version = "0.1.58"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "2fad5b825842d2b38bd206f3e81d6957625fd7f0a361e345c30e01a0ae2dd613"
+checksum = "8326b86b6cff230b97d0d312a6c40a60726df3332e721f72a1b035f451663b20"
 dependencies = [
  "android_system_properties",
  "core-foundation-sys",
  "iana-time-zone-haiku",
  "js-sys",
  "wasm-bindgen",
- "windows",
+ "windows-core",
 ]
 
 [[package]]
@@ -1397,7 +1135,7 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "8adf3ddd720272c6ea8bf59463c04e0f93d0bbf7c5439b691bca2987e0270897"
 dependencies = [
  "equivalent",
- "hashbrown 0.14.1",
+ "hashbrown 0.14.2",
  "serde",
 ]
 
@@ -1458,15 +1196,6 @@ dependencies = [
  "either",
 ]
 
-[[package]]
-name = "itertools-num"
-version = "0.1.3"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "a872a22f9e6f7521ca557660adb96dd830e54f0f490fa115bb55dd69d38b27e7"
-dependencies = [
- "num-traits",
-]
-
 [[package]]
 name = "itoa"
 version = "1.0.9"
@@ -1525,12 +1254,6 @@ dependencies = [
  "winapi",
 ]
 
-[[package]]
-name = "libm"
-version = "0.2.8"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "4ec2a862134d2a7d32d7983ddcdd1c4923530833c9f2ea1a44fc5fa473989058"
-
 [[package]]
 name = "librocksdb-sys"
 version = "0.11.0+8.1.1"
@@ -1547,16 +1270,6 @@ dependencies = [
  "zstd-sys",
 ]
 
-[[package]]
-name = "libsqlite3-sys"
-version = "0.26.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "afc22eff61b133b115c6e8c74e818c628d6d5e7a502afea6f64dee076dd94326"
-dependencies = [
- "pkg-config",
- "vcpkg",
-]
-
 [[package]]
 name = "libz-sys"
 version = "1.1.12"
@@ -1599,9 +1312,9 @@ checksum = "e34f76eb3611940e0e7d53a9aaa4e6a3151f69541a282fd0dad5571420c53ff1"
 
 [[package]]
 name = "lock_api"
-version = "0.4.10"
+version = "0.4.11"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "c1cc9717a20b1bb222f333e6a92fd32f7d8a18ddc5a3191a11af45dcbf4dcd16"
+checksum = "3c168f8615b12bc01f9c17e2eb0cc07dcae1940121185446edc3744920e8ef45"
 dependencies = [
  "autocfg",
  "scopeguard",
@@ -1623,26 +1336,6 @@ dependencies = [
  "libc",
 ]
 
-[[package]]
-name = "matrixmultiply"
-version = "0.3.8"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7574c1cf36da4798ab73da5b215bbf444f50718207754cb522201d78d1cd0ff2"
-dependencies = [
- "autocfg",
- "rawpointer",
-]
-
-[[package]]
-name = "md-5"
-version = "0.10.6"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d89e7ee0cfbedfc4da3340218492196241d89eefb6dab27de5df917a6d2e78cf"
-dependencies = [
- "cfg-if",
- "digest",
-]
-
 [[package]]
 name = "memchr"
 version = "2.6.4"
@@ -1696,60 +1389,6 @@ name = "multimap"
 version = "0.8.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "e5ce46fe64a9d73be07dcbe690a38ce1b293be448fd8ce1e6c1b8062c9f72c6a"
-dependencies = [
- "serde",
-]
-
-[[package]]
-name = "nalgebra"
-version = "0.29.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d506eb7e08d6329505faa8a3a00a5dcc6de9f76e0c77e4b75763ae3c770831ff"
-dependencies = [
- "approx",
- "matrixmultiply",
- "nalgebra-macros",
- "num-complex",
- "num-rational",
- "num-traits",
- "rand",
- "rand_distr",
- "simba",
- "typenum",
-]
-
-[[package]]
-name = "nalgebra-macros"
-version = "0.1.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "01fcc0b8149b4632adc89ac3b7b31a12fb6099a0317a4eb2ebff574ef7de7218"
-dependencies = [
- "proc-macro2",
- "quote",
- "syn 1.0.109",
-]
-
-[[package]]
-name = "ndarray"
-version = "0.15.6"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "adb12d4e967ec485a5f71c6311fe28158e9d6f4bc4a447b474184d0f91a8fa32"
-dependencies = [
- "matrixmultiply",
- "num-complex",
- "num-integer",
- "num-traits",
- "rawpointer",
-]
-
-[[package]]
-name = "newtype_derive"
-version = "0.1.6"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ac8cd24d9f185bb7223958d8c1ff7a961b74b1953fd05dba7cc568a63b3861ec"
-dependencies = [
- "rustc_version 0.1.7",
-]
 
 [[package]]
 name = "nom"
@@ -1770,18 +1409,6 @@ dependencies = [
  "noodles-core",
 ]
 
-[[package]]
-name = "noodles-bgzf"
-version = "0.24.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "8f4c43ff0879c542c1d8fd570c03e368f629587721d10267f2619e36afc9c9b0"
-dependencies = [
- "byteorder",
- "bytes",
- "crossbeam-channel",
- "flate2",
-]
-
 [[package]]
 name = "noodles-bgzf"
 version = "0.25.0"
@@ -1802,26 +1429,14 @@ checksum = "94fbe3192fe33acacabaedd387657f39b0fc606f1996d546db0dfe14703b843a"
 
 [[package]]
 name = "noodles-csi"
-version = "0.25.0"
+version = "0.25.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f327250086b20edade50756b6aee1851d656a3a5967cf94cbe4d4e10a5ef85d7"
+checksum = "39d86e55b4784ba7c38b4ffbfc24e122bc05ce971b0a664e8e1a15ffd9de68a7"
 dependencies = [
  "bit-vec",
  "byteorder",
  "indexmap 2.0.2",
- "noodles-bgzf 0.25.0",
- "noodles-core",
-]
-
-[[package]]
-name = "noodles-fasta"
-version = "0.29.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1012431f881aad1912f9650a8d33e7f7493c6202bc2e889949ec1bc26a55f26d"
-dependencies = [
- "bytes",
- "memchr",
- "noodles-bgzf 0.24.0",
+ "noodles-bgzf",
  "noodles-core",
 ]
 
@@ -1833,7 +1448,7 @@ checksum = "f69786c5eaa25460ae5ea61215f8869edd7eb1728c043f314420cea0bbe59ed3"
 dependencies = [
  "bit-vec",
  "byteorder",
- "noodles-bgzf 0.25.0",
+ "noodles-bgzf",
  "noodles-core",
  "noodles-csi",
 ]
@@ -1846,7 +1461,7 @@ checksum = "a0c31d3f5fd3bef22fcca702e2a85ab93f1c076a9e34cb94bc0c21874d2f4e02"
 dependencies = [
  "indexmap 2.0.2",
  "memchr",
- "noodles-bgzf 0.25.0",
+ "noodles-bgzf",
  "noodles-core",
  "noodles-csi",
  "noodles-tabix",
@@ -1863,36 +1478,6 @@ dependencies = [
  "winapi",
 ]
 
-[[package]]
-name = "num-complex"
-version = "0.4.4"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1ba157ca0885411de85d6ca030ba7e2a83a28636056c7c699b07c8b6f7383214"
-dependencies = [
- "num-traits",
-]
-
-[[package]]
-name = "num-integer"
-version = "0.1.45"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "225d3389fb3509a24c93f5c29eb6bde2586b98d9f016636dff58d7c6f7569cd9"
-dependencies = [
- "autocfg",
- "num-traits",
-]
-
-[[package]]
-name = "num-rational"
-version = "0.4.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "0638a1c9d0a3c0914158145bc76cff373a75a627e6ecbfb71cbe6f453a5a19b0"
-dependencies = [
- "autocfg",
- "num-integer",
- "num-traits",
-]
-
 [[package]]
 name = "num-traits"
 version = "0.2.17"
@@ -1900,7 +1485,6 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "39e3200413f237f41ab11ad6d161bc7239c84dcb631773ccd7de3dfe4b5c267c"
 dependencies = [
  "autocfg",
- "libm",
 ]
 
 [[package]]
@@ -1924,15 +1508,6 @@ version = "1.18.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "dd8b5dd2ae5ed71462c540258bedcb51965123ad7e7ccf4b9a8cafaa4a63576d"
 
-[[package]]
-name = "ordered-float"
-version = "3.9.2"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f1e1c390732d15f1d48471625cd92d154e66db2c56645e29a9cd26f4699f72dc"
-dependencies = [
- "num-traits",
-]
-
 [[package]]
 name = "overload"
 version = "0.1.1"
@@ -1951,13 +1526,13 @@ dependencies = [
 
 [[package]]
 name = "parking_lot_core"
-version = "0.9.8"
+version = "0.9.9"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "93f00c865fe7cabf650081affecd3871070f26767e7b2070a3ffae14c654b447"
+checksum = "4c42a9226546d68acdd9c0a280d17ce19bfe27a46bf68784e4066115788d008e"
 dependencies = [
  "cfg-if",
  "libc",
- "redox_syscall",
+ "redox_syscall 0.4.1",
  "smallvec",
  "windows-targets 0.48.5",
 ]
@@ -1990,24 +1565,6 @@ dependencies = [
  "indexmap 2.0.2",
 ]
 
-[[package]]
-name = "phf"
-version = "0.11.2"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ade2d8b8f33c7333b51bcf0428d37e217e9f32192ae4772156f65063b8ce03dc"
-dependencies = [
- "phf_shared",
-]
-
-[[package]]
-name = "phf_shared"
-version = "0.11.2"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "90fcb95eef784c2ac79119d1dd819e162b5da872ce6f3c3abe1e8ca1c082f72b"
-dependencies = [
- "siphasher",
-]
-
 [[package]]
 name = "pin-project-lite"
 version = "0.2.13"
@@ -2033,48 +1590,10 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "31114a898e107c51bb1609ffaf55a0e011cf6a4d7f1170d0015a165082c0338b"
 
 [[package]]
-name = "postgres"
-version = "0.19.7"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7915b33ed60abc46040cbcaa25ffa1c7ec240668e0477c4f3070786f5916d451"
-dependencies = [
- "bytes",
- "fallible-iterator",
- "futures-util",
- "log",
- "tokio",
- "tokio-postgres",
-]
-
-[[package]]
-name = "postgres-protocol"
-version = "0.6.6"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "49b6c5ef183cd3ab4ba005f1ca64c21e8bd97ce4699cfea9e8d9a2c4958ca520"
-dependencies = [
- "base64",
- "byteorder",
- "bytes",
- "fallible-iterator",
- "hmac",
- "md-5",
- "memchr",
- "rand",
- "sha2",
- "stringprep",
-]
-
-[[package]]
-name = "postgres-types"
-version = "0.2.6"
+name = "powerfmt"
+version = "0.2.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "8d2234cdee9408b523530a9b6d2d6b373d1db34f6a8e51dc03ded1828d7fb67c"
-dependencies = [
- "bytes",
- "chrono",
- "fallible-iterator",
- "postgres-protocol",
-]
+checksum = "439ee305def115ba05938db6eb1644ff94165c5ab5e9420d1c1bcedbba909391"
 
 [[package]]
 name = "ppv-lite86"
@@ -2102,30 +1621,6 @@ dependencies = [
  "syn 2.0.38",
 ]
 
-[[package]]
-name = "proc-macro-error"
-version = "1.0.4"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "da25490ff9892aab3fcf7c36f08cfb902dd3e71ca0f9f9517bea02a73a5ce38c"
-dependencies = [
- "proc-macro-error-attr",
- "proc-macro2",
- "quote",
- "syn 1.0.109",
- "version_check",
-]
-
-[[package]]
-name = "proc-macro-error-attr"
-version = "1.0.4"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "a1be40180e52ecc98ad80b184934baf3d0d29f979574e439af5a55274b35f869"
-dependencies = [
- "proc-macro2",
- "quote",
- "version_check",
-]
-
 [[package]]
 name = "proc-macro2"
 version = "1.0.69"
@@ -2189,18 +1684,6 @@ dependencies = [
  "prost",
 ]
 
-[[package]]
-name = "quick_cache"
-version = "0.4.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f69f8d22fa3f34f3083d9a4375c038732c7a7e964de1beb81c544da92dfc40b8"
-dependencies = [
- "ahash",
- "equivalent",
- "hashbrown 0.14.1",
- "parking_lot",
-]
-
 [[package]]
 name = "quote"
 version = "1.0.33"
@@ -2240,22 +1723,6 @@ dependencies = [
  "getrandom",
 ]
 
-[[package]]
-name = "rand_distr"
-version = "0.4.3"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "32cb0b9bc82b0a0876c2dd994a7e7a2683d3e7390ca40e6886785ef0c7e3ee31"
-dependencies = [
- "num-traits",
- "rand",
-]
-
-[[package]]
-name = "rawpointer"
-version = "0.2.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "60a357793950651c4ed0f3f52338f53b2f809f32d83a07f72909fa13e4c6c1e3"
-
 [[package]]
 name = "rayon"
 version = "1.8.0"
@@ -2285,11 +1752,20 @@ dependencies = [
  "bitflags 1.3.2",
 ]
 
+[[package]]
+name = "redox_syscall"
+version = "0.4.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "4722d768eff46b75989dd134e5c353f0d6296e5aaa3132e776cbdb56be7731aa"
+dependencies = [
+ "bitflags 1.3.2",
+]
+
 [[package]]
 name = "regex"
-version = "1.10.0"
+version = "1.10.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d119d7c7ca818f8a53c300863d4f87566aac09943aef5b355bb83969dae75d87"
+checksum = "380b951a9c5e80ddfd6136919eef32310721aa4aacd4889a8d39124b026ab343"
 dependencies = [
  "aho-corasick",
  "memchr",
@@ -2299,9 +1775,9 @@ dependencies = [
 
 [[package]]
 name = "regex-automata"
-version = "0.4.1"
+version = "0.4.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "465c6fc0621e4abc4187a2bda0937bfd4f722c2730b29562e19689ea796c9a4b"
+checksum = "5f804c7828047e88b2d32e2d7fe5a105da8ee3264f01902f796c8e067dc2483f"
 dependencies = [
  "aho-corasick",
  "memchr",
@@ -2310,9 +1786,9 @@ dependencies = [
 
 [[package]]
 name = "regex-syntax"
-version = "0.8.1"
+version = "0.8.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "56d84fdd47036b038fc80dd333d10b6aab10d5d31f4a366e20014def75328d33"
+checksum = "c08c74e62047bb2de4ff487b251e4a92e24f48745648451635cec7d591162d9f"
 
 [[package]]
 name = "rocksdb"
@@ -2335,20 +1811,6 @@ dependencies = [
  "tracing",
 ]
 
-[[package]]
-name = "rusqlite"
-version = "0.29.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "549b9d036d571d42e6e85d1c1425e2ac83491075078ca9a15be021c56b1641f2"
-dependencies = [
- "bitflags 2.4.0",
- "fallible-iterator",
- "fallible-streaming-iterator",
- "hashlink",
- "libsqlite3-sys",
- "smallvec",
-]
-
 [[package]]
 name = "rustc-demangle"
 version = "0.1.23"
@@ -2361,31 +1823,22 @@ version = "1.1.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "08d43f7aa6b08d49f382cde6a7982047c3426db949b1424bc4b7ec9ae12c6ce2"
 
-[[package]]
-name = "rustc_version"
-version = "0.1.7"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "c5f5376ea5e30ce23c03eb77cbe4962b988deead10910c372b226388b594c084"
-dependencies = [
- "semver 0.1.20",
-]
-
 [[package]]
 name = "rustc_version"
 version = "0.4.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "bfa0f585226d2e68097d4f95d113b15b83a82e819ab25717ec0590d9584ef366"
 dependencies = [
- "semver 1.0.20",
+ "semver",
 ]
 
 [[package]]
 name = "rustix"
-version = "0.38.18"
+version = "0.38.20"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "5a74ee2d7c2581cd139b42447d7d9389b889bdaad3a73f1ebb16f2a3237bb19c"
+checksum = "67ce50cb2e16c2903e30d1cbccfd8387a74b9d4c938b6a4c5ec6cc7556f7a8a0"
 dependencies = [
- "bitflags 2.4.0",
+ "bitflags 2.4.1",
  "errno",
  "libc",
  "linux-raw-sys",
@@ -2404,48 +1857,18 @@ version = "1.0.15"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "1ad4cc8da4ef723ed60bced201181d83791ad433213d8c24efffda1eec85d741"
 
-[[package]]
-name = "safe_arch"
-version = "0.7.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f398075ce1e6a179b46f51bd88d0598b92b00d3551f1a2d4ac49e771b56ac354"
-dependencies = [
- "bytemuck",
-]
-
 [[package]]
 name = "scopeguard"
 version = "1.2.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "94143f37725109f92c262ed2cf5e59bce7498c01bcc1502d7b9afe439a4e9f49"
 
-[[package]]
-name = "semver"
-version = "0.1.20"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d4f410fedcf71af0345d7607d246e7ad15faaadd49d240ee3b24e5dc21a820ac"
-
 [[package]]
 name = "semver"
 version = "1.0.20"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "836fa6a3e1e547f9a2c4040802ec865b5d85f4014efe00555d7090a3dcaa1090"
 
-[[package]]
-name = "seqrepo"
-version = "0.8.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "94b3579efbd2915e936798fb9f52629feec3cbeef1ef23eb556d49d89ff31455"
-dependencies = [
- "chrono",
- "noodles-bgzf 0.24.0",
- "noodles-core",
- "noodles-fasta",
- "rusqlite",
- "thiserror",
- "tracing",
-]
-
 [[package]]
 name = "serde"
 version = "1.0.189"
@@ -2492,9 +1915,9 @@ dependencies = [
 
 [[package]]
 name = "serde_with"
-version = "3.3.0"
+version = "3.4.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1ca3b16a3d82c4088f343b7480a93550b3eabe1a358569c2dfe38bbcead07237"
+checksum = "64cd236ccc1b7a29e7e2739f27c0b2dd199804abc4290e32f59f3b68d6405c23"
 dependencies = [
  "base64",
  "chrono",
@@ -2509,9 +1932,9 @@ dependencies = [
 
 [[package]]
 name = "serde_with_macros"
-version = "3.3.0"
+version = "3.4.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "2e6be15c453eb305019bfa438b1593c731f36a289a7853f7707ee29e870b3b3c"
+checksum = "93634eb5f75a2323b16de4748022ac4297f9e76b6dced2be287a099f41b5e788"
 dependencies = [
  "darling",
  "proc-macro2",
@@ -2530,17 +1953,6 @@ dependencies = [
  "digest",
 ]
 
-[[package]]
-name = "sha2"
-version = "0.10.8"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "793db75ad2bcafc3ffa7c68b215fee268f537982cd901d132f89c6343f3a3dc8"
-dependencies = [
- "cfg-if",
- "cpufeatures",
- "digest",
-]
-
 [[package]]
 name = "sharded-slab"
 version = "0.1.7"
@@ -2565,31 +1977,12 @@ dependencies = [
  "libc",
 ]
 
-[[package]]
-name = "simba"
-version = "0.6.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f0b7840f121a46d63066ee7a99fc81dcabbc6105e437cae43528cea199b5a05f"
-dependencies = [
- "approx",
- "num-complex",
- "num-traits",
- "paste",
- "wide",
-]
-
 [[package]]
 name = "similar"
 version = "2.3.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "2aeaf503862c419d66959f5d7ca015337d864e9c49485d771b732e2a20453597"
 
-[[package]]
-name = "siphasher"
-version = "0.3.11"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "38b58827f4464d87d377d175e90bf58eb00fd8716ff0a62f80356b5e61555d0d"
-
 [[package]]
 name = "slab"
 version = "0.4.9"
@@ -2607,38 +2000,14 @@ checksum = "942b4a808e05215192e39f4ab80813e599068285906cc91aa64f923db842bd5a"
 
 [[package]]
 name = "socket2"
-version = "0.5.4"
+version = "0.5.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "4031e820eb552adee9295814c0ced9e5cf38ddf1e8b7d566d6de8e2538ea989e"
+checksum = "7b5fac59a5cb5dd637972e5fca70daf0523c9067fcdc4842f053dae04a18f8e9"
 dependencies = [
  "libc",
  "windows-sys 0.48.0",
 ]
 
-[[package]]
-name = "statrs"
-version = "0.16.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "2d08e5e1748192713cc281da8b16924fb46be7b0c2431854eadc785823e5696e"
-dependencies = [
- "approx",
- "lazy_static",
- "nalgebra",
- "num-traits",
- "rand",
-]
-
-[[package]]
-name = "stringprep"
-version = "0.1.4"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "bb41d74e231a107a1b4ee36bd1214b11285b77768d2e3824aedafa988fd36ee6"
-dependencies = [
- "finl_unicode",
- "unicode-bidi",
- "unicode-normalization",
-]
-
 [[package]]
 name = "strsim"
 version = "0.10.0"
@@ -2656,9 +2025,9 @@ dependencies = [
 
 [[package]]
 name = "strum_macros"
-version = "0.25.2"
+version = "0.25.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ad8d03b598d3d0fff69bf533ee3ef19b8eeb342729596df84bcc7e1f96ec4059"
+checksum = "23dc1fa9ac9c169a78ba62f0b841814b7abae11bdd047b9c58f893439e309ea0"
 dependencies = [
  "heck",
  "proc-macro2",
@@ -2667,12 +2036,6 @@ dependencies = [
  "syn 2.0.38",
 ]
 
-[[package]]
-name = "subtle"
-version = "2.5.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "81cdd64d312baedb58e21336b31bc043b77e01cc99033ce76ef539f78e965ebc"
-
 [[package]]
 name = "syn"
 version = "1.0.109"
@@ -2709,7 +2072,7 @@ checksum = "cb94d2f3cc536af71caac6b6fcebf65860b347e7ce0cc9ebe8f70d3e521054ef"
 dependencies = [
  "cfg-if",
  "fastrand",
- "redox_syscall",
+ "redox_syscall 0.3.5",
  "rustix",
  "windows-sys 0.48.0",
 ]
@@ -2736,18 +2099,18 @@ dependencies = [
 
 [[package]]
 name = "thiserror"
-version = "1.0.49"
+version = "1.0.50"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1177e8c6d7ede7afde3585fd2513e611227efd6481bd78d2e82ba1ce16557ed4"
+checksum = "f9a7210f5c9a7156bb50aa36aed4c95afb51df0df00713949448cf9e97d382d2"
 dependencies = [
  "thiserror-impl",
 ]
 
 [[package]]
 name = "thiserror-impl"
-version = "1.0.49"
+version = "1.0.50"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "10712f02019e9288794769fba95cd6847df9874d49d871d062172f9dd41bc4cc"
+checksum = "266b2e40bc00e5a6c09c3584011e08b06f123c00362c92b975ba9843aaaa14b8"
 dependencies = [
  "proc-macro2",
  "quote",
@@ -2766,12 +2129,13 @@ dependencies = [
 
 [[package]]
 name = "time"
-version = "0.3.29"
+version = "0.3.30"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "426f806f4089c493dcac0d24c29c01e2c38baf8e30f1b716ee37e83d200b18fe"
+checksum = "c4a34ab300f2dee6e562c10a046fc05e358b29f9bf92277f30c3c8d82275f6f5"
 dependencies = [
  "deranged",
  "itoa",
+ "powerfmt",
  "serde",
  "time-core",
  "time-macros",
@@ -2824,32 +2188,6 @@ dependencies = [
  "windows-sys 0.48.0",
 ]
 
-[[package]]
-name = "tokio-postgres"
-version = "0.7.10"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "d340244b32d920260ae7448cb72b6e238bddc3d4f7603394e7dd46ed8e48f5b8"
-dependencies = [
- "async-trait",
- "byteorder",
- "bytes",
- "fallible-iterator",
- "futures-channel",
- "futures-util",
- "log",
- "parking_lot",
- "percent-encoding",
- "phf",
- "pin-project-lite",
- "postgres-protocol",
- "postgres-types",
- "rand",
- "socket2",
- "tokio",
- "tokio-util",
- "whoami",
-]
-
 [[package]]
 name = "tokio-util"
 version = "0.7.9"
@@ -2866,9 +2204,9 @@ dependencies = [
 
 [[package]]
 name = "tracing"
-version = "0.1.39"
+version = "0.1.40"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ee2ef2af84856a50c1d430afce2fdded0a4ec7eda868db86409b4543df0797f9"
+checksum = "c3523ab5a71916ccf420eebdf5521fcef02141234bbc0b8a49f2fdc4544364ef"
 dependencies = [
  "log",
  "pin-project-lite",
@@ -2922,12 +2260,6 @@ dependencies = [
  "tracing-log",
 ]
 
-[[package]]
-name = "triple_accel"
-version = "0.4.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "22048bc95dfb2ffd05b1ff9a756290a009224b60b2f0e7525faeee7603851e63"
-
 [[package]]
 name = "typenum"
 version = "1.17.0"
@@ -2990,15 +2322,6 @@ version = "0.2.15"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "accd4ea62f7bb7a82fe23066fb0957d48ef677f6eeb8215f372f52e48bb32426"
 
-[[package]]
-name = "vec_map"
-version = "0.8.2"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f1bddf1187be692e79c5ffeab891132dfb0f236ed36a43c7ed39f1165ee20191"
-dependencies = [
- "serde",
-]
-
 [[package]]
 name = "version_check"
 version = "0.9.4"
@@ -3065,16 +2388,6 @@ version = "0.2.87"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "ca6ad05a4870b2bf5fe995117d3728437bd27d7cd5f06f13c17443ef369775a1"
 
-[[package]]
-name = "web-sys"
-version = "0.3.64"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "9b85cbef8c220a6abc02aefd892dfc0fc23afb1c6a426316ec33253a3877249b"
-dependencies = [
- "js-sys",
- "wasm-bindgen",
-]
-
 [[package]]
 name = "which"
 version = "4.4.2"
@@ -3087,26 +2400,6 @@ dependencies = [
  "rustix",
 ]
 
-[[package]]
-name = "whoami"
-version = "1.4.1"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "22fc3756b8a9133049b26c7f61ab35416c130e8c09b660f5b3958b446f52cc50"
-dependencies = [
- "wasm-bindgen",
- "web-sys",
-]
-
-[[package]]
-name = "wide"
-version = "0.7.12"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ebecebefc38ff1860b4bc47550bbfa63af5746061cf0d29fcd7fa63171602598"
-dependencies = [
- "bytemuck",
- "safe_arch",
-]
-
 [[package]]
 name = "winapi"
 version = "0.3.9"
@@ -3139,10 +2432,10 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "712e227841d057c1ee1cd2fb22fa7e5a5461ae8e48fa2ca79ec42cfc1931183f"
 
 [[package]]
-name = "windows"
-version = "0.48.0"
+name = "windows-core"
+version = "0.51.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e686886bc078bc1b0b600cac0147aadb815089b6e4da64016cbd754b6342700f"
+checksum = "f1f8cf84f35d2db49a46868f947758c7a1138116f7fac3bc844f43ade1292e64"
 dependencies = [
  "windows-targets 0.48.5",
 ]
diff --git a/Cargo.toml b/Cargo.toml
index e858e341..cc762c0b 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -30,7 +30,6 @@ csv = "1.2"
 enum-map = { version = "2.6.3", features = ["serde"] }
 env_logger = "0.10"
 flate2 = "1.0"
-hgvs = "0.11"
 indexmap = { version = "2.0", features = ["serde"] }
 indicatif = { version = "0.17", features = ["rayon"] }
 log = "0.4"
@@ -51,6 +50,7 @@ strum = { version = "0.25", features = ["strum_macros", "derive"] }
 thiserror = "1.0"
 tracing = "0.1"
 tracing-subscriber = "0.3"
+biocommons-bioutils = "0.1.0"
 
 [build-dependencies]
 prost-build = "0.12"
diff --git a/src/common/cli.rs b/src/common/cli.rs
index b0f20801..ff49ac9c 100644
--- a/src/common/cli.rs
+++ b/src/common/cli.rs
@@ -40,11 +40,11 @@ pub enum GenomeRelease {
     Grch38,
 }
 
-impl From<GenomeRelease> for hgvs::static_data::Assembly {
+impl From<GenomeRelease> for biocommons_bioutils::assemblies::Assembly {
     fn from(val: GenomeRelease) -> Self {
         match val {
-            GenomeRelease::Grch37 => hgvs::static_data::Assembly::Grch37p10,
-            GenomeRelease::Grch38 => hgvs::static_data::Assembly::Grch38,
+            GenomeRelease::Grch37 => biocommons_bioutils::assemblies::Assembly::Grch37p10,
+            GenomeRelease::Grch38 => biocommons_bioutils::assemblies::Assembly::Grch38,
         }
     }
 }
@@ -104,12 +104,12 @@ pub fn is_canonical(chrom: &str) -> bool {
 
 /// Build windows for a given assembly.
 pub fn build_genome_windows(
-    assembly: hgvs::static_data::Assembly,
+    assembly: biocommons_bioutils::assemblies::Assembly,
     window_size: Option<usize>,
 ) -> Result<Vec<(String, usize, usize)>, anyhow::Error> {
     let mut result = Vec::new();
 
-    for seq in &hgvs::static_data::ASSEMBLY_INFOS[assembly].sequences {
+    for seq in &biocommons_bioutils::assemblies::ASSEMBLY_INFOS[assembly].sequences {
         if is_canonical(&seq.name) {
             let window_size = window_size.unwrap_or(seq.length);
             let mut start = 0;
diff --git a/src/dbsnp/cli/import.rs b/src/dbsnp/cli/import.rs
index 97ae0e53..0d68e2d1 100644
--- a/src/dbsnp/cli/import.rs
+++ b/src/dbsnp/cli/import.rs
@@ -2,8 +2,8 @@
 
 use std::{str::FromStr, sync::Arc};
 
+use biocommons_bioutils::assemblies::Assembly;
 use clap::Parser;
-use hgvs::static_data::Assembly;
 use indicatif::ParallelProgressIterator;
 use noodles_vcf::header::record;
 use prost::Message;
diff --git a/src/freqs/cli/import/mod.rs b/src/freqs/cli/import/mod.rs
index 1fc842af..a1c522ad 100644
--- a/src/freqs/cli/import/mod.rs
+++ b/src/freqs/cli/import/mod.rs
@@ -69,7 +69,7 @@ pub struct Args {
 /// Return mapping from chromosome to path.
 fn assign_to_chrom(
     paths: &Vec<String>,
-    assembly: hgvs::static_data::Assembly,
+    assembly: biocommons_bioutils::assemblies::Assembly,
 ) -> Result<HashMap<usize, String>, anyhow::Error> {
     let contig_map = ContigMap::new(assembly);
     let mut res = HashMap::new();
@@ -93,7 +93,7 @@ fn assign_to_chrom(
 
 /// Get windows for the up to two given paths.
 pub fn build_windows(
-    genome_release: hgvs::static_data::Assembly,
+    genome_release: biocommons_bioutils::assemblies::Assembly,
     tbi_window_size: usize,
     paths: &[String],
 ) -> Result<Vec<(String, usize, usize)>, anyhow::Error> {
@@ -149,8 +149,8 @@ pub fn run(common: &common::cli::Args, args: &Args) -> Result<(), anyhow::Error>
 
     // Guess genome release from paths.
     let genome_release = match args.genome_release {
-        common::cli::GenomeRelease::Grch37 => hgvs::static_data::Assembly::Grch37p10, // has chrMT!
-        common::cli::GenomeRelease::Grch38 => hgvs::static_data::Assembly::Grch38,
+        common::cli::GenomeRelease::Grch37 => biocommons_bioutils::assemblies::Assembly::Grch37p10, // has chrMT!
+        common::cli::GenomeRelease::Grch38 => biocommons_bioutils::assemblies::Assembly::Grch38,
     };
 
     // Open the RocksDB for writing.
diff --git a/src/freqs/cli/import/reading.rs b/src/freqs/cli/import/reading.rs
index c32a8703..51787886 100644
--- a/src/freqs/cli/import/reading.rs
+++ b/src/freqs/cli/import/reading.rs
@@ -2,7 +2,7 @@
 
 use std::collections::{BTreeMap, HashMap};
 
-use hgvs::static_data::{Assembly, ASSEMBLY_INFOS};
+use biocommons_bioutils::assemblies::{Assembly, ASSEMBLY_INFOS};
 
 use crate::common::cli::CANONICAL;
 
@@ -230,7 +230,7 @@ pub fn guess_assembly(
 
 #[cfg(test)]
 mod test {
-    use hgvs::static_data::Assembly;
+    use biocommons_bioutils::assemblies::Assembly;
 
     use super::*;