diff --git a/packages/vite/src/node/plugins/esbuild.ts b/packages/vite/src/node/plugins/esbuild.ts
index bd736f9671fdf3..eed44dc9c0379c 100644
--- a/packages/vite/src/node/plugins/esbuild.ts
+++ b/packages/vite/src/node/plugins/esbuild.ts
@@ -25,9 +25,10 @@ import type { Plugin } from '../plugin'
 
 const debug = createDebugger('vite:esbuild')
 
-// IIFE content looks like `var MyLib = function() {`. Spaces are removed when minified
+// IIFE content looks like `var MyLib = function() {`.
+// Spaces are removed and parameters are mangled when minified
 const IIFE_BEGIN_RE =
-  /(const|var)\s+\S+\s*=\s*function\(\)\s*\{.*"use strict";/s
+  /(const|var)\s+\S+\s*=\s*function\([^()]*\)\s*\{\s*"use strict";/
 
 const validExtensionRE = /\.\w+$/
 const jsxExtensionsRE = /\.(?:j|t)sx\b/
diff --git a/playground/lib/__tests__/lib.spec.ts b/playground/lib/__tests__/lib.spec.ts
index 682fd5aeba6c85..eb1d2cd9ee5ae8 100644
--- a/playground/lib/__tests__/lib.spec.ts
+++ b/playground/lib/__tests__/lib.spec.ts
@@ -19,11 +19,13 @@ describe.runIf(isBuild)('build', () => {
     const noMinifyCode = readFile(
       'dist/nominify/my-lib-custom-filename.umd.cjs',
     )
+    const namedCode = readFile('dist/named/my-lib-named.umd.cjs')
     // esbuild helpers are injected inside of the UMD wrapper
     expect(code).toMatch(/^\(function\(/)
     expect(noMinifyCode).toMatch(
       /^\(function\(global.+?"use strict";var.+?function\smyLib\(/s,
     )
+    expect(namedCode).toMatch(/^\(function\(/)
   })
 
   test('iife', async () => {
@@ -32,11 +34,15 @@ describe.runIf(isBuild)('build', () => {
     const noMinifyCode = readFile(
       'dist/nominify/my-lib-custom-filename.iife.js',
     )
+    const namedCode = readFile('dist/named/my-lib-named.iife.js')
     // esbuild helpers are injected inside of the IIFE wrapper
     expect(code).toMatch(/^var MyLib=function\(\)\{\s*"use strict";/)
     expect(noMinifyCode).toMatch(
       /^var MyLib\s*=\s*function\(\)\s*\{\s*"use strict";/,
     )
+    expect(namedCode).toMatch(
+      /^var MyLibNamed=function\([^()]+\)\{\s*"use strict";/,
+    )
   })
 
   test('restrisct-helpers-injection', async () => {
diff --git a/playground/lib/__tests__/serve.ts b/playground/lib/__tests__/serve.ts
index e07efe526eaf00..249bc7de4fec43 100644
--- a/playground/lib/__tests__/serve.ts
+++ b/playground/lib/__tests__/serve.ts
@@ -82,6 +82,12 @@ export async function serve(): Promise<{ close(): Promise<void> }> {
       ),
     })
 
+    await build({
+      root: rootDir,
+      logLevel: 'warn', // output esbuild warns
+      configFile: path.resolve(__dirname, '../vite.named-exports.config.js'),
+    })
+
     // start static file server
     const serve = sirv(path.resolve(rootDir, 'dist'))
     const httpServer = http.createServer((req, res) => {
diff --git a/playground/lib/src/main-named.js b/playground/lib/src/main-named.js
new file mode 100644
index 00000000000000..238bedb07c3507
--- /dev/null
+++ b/playground/lib/src/main-named.js
@@ -0,0 +1,4 @@
+export const foo = 'foo'
+
+// Force esbuild spread helpers
+console.log({ ...foo })
diff --git a/playground/lib/vite.named-exports.config.js b/playground/lib/vite.named-exports.config.js
new file mode 100644
index 00000000000000..5c2f3bdb7f3db9
--- /dev/null
+++ b/playground/lib/vite.named-exports.config.js
@@ -0,0 +1,20 @@
+import path from 'node:path'
+import { defineConfig } from 'vite'
+
+export default defineConfig({
+  esbuild: {
+    supported: {
+      // Force esbuild inject helpers to test regex
+      'object-rest-spread': false,
+    },
+  },
+  build: {
+    lib: {
+      entry: path.resolve(__dirname, 'src/main-named.js'),
+      name: 'MyLibNamed',
+      formats: ['umd', 'iife'],
+      fileName: 'my-lib-named',
+    },
+    outDir: 'dist/named',
+  },
+})