diff --git a/packages/vite/src/node/plugins/resolve.ts b/packages/vite/src/node/plugins/resolve.ts
index 1d64e1da55b5a3..1976de78f64258 100644
--- a/packages/vite/src/node/plugins/resolve.ts
+++ b/packages/vite/src/node/plugins/resolve.ts
@@ -182,6 +182,7 @@ export function resolvePlugin(resolveOptions: InternalResolveOptions): Plugin {
       const ensureVersionQuery = (resolved: string): string => {
         if (
           !options.isBuild &&
+          !options.scan &&
           depsOptimizer &&
           !(
             resolved === normalizedClientEntry ||
diff --git a/playground/optimize-deps/__tests__/optimize-deps.spec.ts b/playground/optimize-deps/__tests__/optimize-deps.spec.ts
index 2137d068372c6a..bb0841e5b72f65 100644
--- a/playground/optimize-deps/__tests__/optimize-deps.spec.ts
+++ b/playground/optimize-deps/__tests__/optimize-deps.spec.ts
@@ -143,6 +143,12 @@ test('import aliased package with colon', async () => {
   expect(await page.textContent('.url')).toBe('vitejs.dev')
 })
 
+test('import aliased package using absolute path', async () => {
+  expect(await page.textContent('.alias-using-absolute-path')).toBe(
+    'From dep-alias-using-absolute-path',
+  )
+})
+
 test('variable names are reused in different scripts', async () => {
   expect(await page.textContent('.reused-variable-names')).toBe('reused')
 })
diff --git a/playground/optimize-deps/dep-alias-using-absolute-path/index.js b/playground/optimize-deps/dep-alias-using-absolute-path/index.js
new file mode 100644
index 00000000000000..82b1f4d1f0874f
--- /dev/null
+++ b/playground/optimize-deps/dep-alias-using-absolute-path/index.js
@@ -0,0 +1,13 @@
+// Importing a shared dependency used by other modules,
+// so dependency optimizer creates a common chunk.
+// This is used to setup a test scenario, where dep scanner
+// could not determine all of the used dependencies on first
+// pass, e.g., a dependency that is aliased using an absolute
+// path, in which case it used to trigger unnecessary "full
+// reloads" invalidating all modules in a module graph.
+const cloneDeep = require('lodash/cloneDeep')
+
+// no-op, using imported module for sake of completeness
+module.exports = cloneDeep({
+  message: 'From dep-alias-using-absolute-path',
+}).message
diff --git a/playground/optimize-deps/dep-alias-using-absolute-path/package.json b/playground/optimize-deps/dep-alias-using-absolute-path/package.json
new file mode 100644
index 00000000000000..3a43490c40ba48
--- /dev/null
+++ b/playground/optimize-deps/dep-alias-using-absolute-path/package.json
@@ -0,0 +1,9 @@
+{
+  "name": "@vitejs/test-dep-alias-using-absolute-path",
+  "private": true,
+  "version": "1.0.0",
+  "main": "index.js",
+  "dependencies": {
+    "lodash": "^4.17.21"
+  }
+}
diff --git a/playground/optimize-deps/dynamic-use-dep-alias-using-absolute-path.js b/playground/optimize-deps/dynamic-use-dep-alias-using-absolute-path.js
new file mode 100644
index 00000000000000..784123a81ec685
--- /dev/null
+++ b/playground/optimize-deps/dynamic-use-dep-alias-using-absolute-path.js
@@ -0,0 +1,6 @@
+// This is used to setup a test scenario, where dep scanner
+// could not determine all of the used dependencies on first
+// pass, e.g., a dependency that is aliased using an absolute
+// path, in which case it used to trigger unnecessary "full
+// reloads" invalidating all modules in a module graph.
+export { default } from '@vitejs/test-dep-alias-using-absolute-path'
diff --git a/playground/optimize-deps/index.html b/playground/optimize-deps/index.html
index 2e24f421542fe7..921bf244c08d8d 100644
--- a/playground/optimize-deps/index.html
+++ b/playground/optimize-deps/index.html
@@ -83,6 +83,9 @@ <h2>Nested include</h2>
 <h2>Alias with colon</h2>
 <div>URL: <span class="url"></span></div>
 
+<h2>Alias using absolute path</h2>
+<div class="alias-using-absolute-path"></div>
+
 <h2>Reused variable names</h2>
 <div>This should show reused: <span class="reused-variable-names"></span></div>
 
@@ -153,6 +156,10 @@ <h2>Non Optimized Module isn't duplicated</h2>
   import { parse } from 'node:url'
   text('.url', parse('https://vitejs.dev').hostname)
 
+  import('./dynamic-use-dep-alias-using-absolute-path.js').then((mod) =>
+    text('.alias-using-absolute-path', mod.default),
+  )
+
   import './index.astro'
 
   // All these imports should end up resolved to the same URL (same ?v= injected on them)
diff --git a/playground/optimize-deps/package.json b/playground/optimize-deps/package.json
index 675dd035e494d2..238c442b351310 100644
--- a/playground/optimize-deps/package.json
+++ b/playground/optimize-deps/package.json
@@ -11,6 +11,7 @@
   "dependencies": {
     "axios": "^0.27.2",
     "clipboard": "^2.0.11",
+    "@vitejs/test-dep-alias-using-absolute-path": "file:./dep-alias-using-absolute-path",
     "@vitejs/test-dep-cjs-browser-field-bare": "file:./dep-cjs-browser-field-bare",
     "@vitejs/test-dep-cjs-compiled-from-cjs": "file:./dep-cjs-compiled-from-cjs",
     "@vitejs/test-dep-cjs-compiled-from-esm": "file:./dep-cjs-compiled-from-esm",
diff --git a/playground/optimize-deps/entry.js b/playground/optimize-deps/unused-split-entry.js
similarity index 100%
rename from playground/optimize-deps/entry.js
rename to playground/optimize-deps/unused-split-entry.js
diff --git a/playground/optimize-deps/vite.config.js b/playground/optimize-deps/vite.config.js
index b07f519783762e..24278a449012fc 100644
--- a/playground/optimize-deps/vite.config.js
+++ b/playground/optimize-deps/vite.config.js
@@ -11,6 +11,9 @@ module.exports = {
     dedupe: ['react'],
     alias: {
       'node:url': 'url',
+      '@vitejs/test-dep-alias-using-absolute-path': require.resolve(
+        '@vitejs/test-dep-alias-using-absolute-path',
+      ),
     },
   },
   optimizeDeps: {
@@ -38,7 +41,7 @@ module.exports = {
         },
       ],
     },
-    entries: ['entry.js'],
+    entries: ['index.html', 'unused-split-entry.js'],
   },
 
   build: {
diff --git a/pnpm-lock.yaml b/pnpm-lock.yaml
index 8e48e76538290a..dbd2a52a797c0e 100644
--- a/pnpm-lock.yaml
+++ b/pnpm-lock.yaml
@@ -616,6 +616,7 @@ importers:
   playground/optimize-deps:
     specifiers:
       '@vitejs/test-added-in-entries': file:./added-in-entries
+      '@vitejs/test-dep-alias-using-absolute-path': file:./dep-alias-using-absolute-path
       '@vitejs/test-dep-cjs-browser-field-bare': file:./dep-cjs-browser-field-bare
       '@vitejs/test-dep-cjs-compiled-from-cjs': file:./dep-cjs-compiled-from-cjs
       '@vitejs/test-dep-cjs-compiled-from-esm': file:./dep-cjs-compiled-from-esm
@@ -646,6 +647,7 @@ importers:
       vuex: ^4.1.0
     dependencies:
       '@vitejs/test-added-in-entries': file:playground/optimize-deps/added-in-entries
+      '@vitejs/test-dep-alias-using-absolute-path': file:playground/optimize-deps/dep-alias-using-absolute-path
       '@vitejs/test-dep-cjs-browser-field-bare': file:playground/optimize-deps/dep-cjs-browser-field-bare
       '@vitejs/test-dep-cjs-compiled-from-cjs': file:playground/optimize-deps/dep-cjs-compiled-from-cjs
       '@vitejs/test-dep-cjs-compiled-from-esm': file:playground/optimize-deps/dep-cjs-compiled-from-esm
@@ -678,6 +680,12 @@ importers:
   playground/optimize-deps/added-in-entries:
     specifiers: {}
 
+  playground/optimize-deps/dep-alias-using-absolute-path:
+    specifiers:
+      lodash: ^4.17.21
+    dependencies:
+      lodash: 4.17.21
+
   playground/optimize-deps/dep-cjs-browser-field-bare:
     specifiers: {}
 
@@ -9926,6 +9934,14 @@ packages:
     version: 1.0.0
     dev: false
 
+  file:playground/optimize-deps/dep-alias-using-absolute-path:
+    resolution: {directory: playground/optimize-deps/dep-alias-using-absolute-path, type: directory}
+    name: '@vitejs/test-dep-alias-using-absolute-path'
+    version: 1.0.0
+    dependencies:
+      lodash: 4.17.21
+    dev: false
+
   file:playground/optimize-deps/dep-cjs-browser-field-bare:
     resolution: {directory: playground/optimize-deps/dep-cjs-browser-field-bare, type: directory}
     name: '@vitejs/test-dep-cjs-browser-field-bare'