[WP4263 Discussion]: not presented c-myc and TP53 interaction which is a key for Carcinogenesis model

[KestUrba]

Discussion

Unfortunately, the interaction of c-myc, the "oncogene emperor", represented by the PROLIFERATIVE genes, with tp53, another essential carcinogenesis gene, is very important, but their interaction is not shown.

"The functions of the proto-oncoprotein c-Myc and the tumor suppressor p53 in controlling cell survival and proliferation are inextricably linked as “Yin and Yang” partners in normal cells to maintain tissue homeostasis: c-Myc induces the expression of ARF tumor suppressor (p14ARF in human and p19ARF in mouse) that binds to and inhibits mouse double minute 2 homolog (MDM2) leading to p53 activation, whereas p53 suppresses c-Myc through a combination of mechanisms involving transcriptional inactivation and microRNA-mediated repression. .."

From Zhang YY, La T, Tabatabaee H, Yan XG, Jamaluddin MFB, Zhang D, Guo ST, Scott RJ, Liu T, Thorne RF, Zhang XD, Jin L. c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis. Nat Commun. 2020 Oct 5;11(1):4980. doi: 10.1038/s41467-020-18735-8. PMID: 33020477; PMCID: PMC7536215.
https://pubmed.ncbi.nlm.nih.gov/33020477/

Type of revision

• Major
• Minor
• Deletion