diff --git a/.changeset/red-masks-drop.md b/.changeset/red-masks-drop.md
new file mode 100644
index 000000000000..3564fa9e8a53
--- /dev/null
+++ b/.changeset/red-masks-drop.md
@@ -0,0 +1,5 @@
+---
+'astro': patch
+---
+
+Fix `tsconfig.json` update causing the server to crash
diff --git a/packages/astro/src/content/vite-plugin-content-imports.ts b/packages/astro/src/content/vite-plugin-content-imports.ts
index 4643e0922872..15ca6d956b11 100644
--- a/packages/astro/src/content/vite-plugin-content-imports.ts
+++ b/packages/astro/src/content/vite-plugin-content-imports.ts
@@ -148,9 +148,15 @@ export const _internal = {
 								hasContentFlag(modUrl, DATA_FLAG) ||
 								Boolean(getContentRendererByViteId(modUrl, settings))
 							) {
-								const mod = await viteServer.moduleGraph.getModuleByUrl(modUrl);
-								if (mod) {
-									viteServer.moduleGraph.invalidateModule(mod);
+								try {
+									const mod = await viteServer.moduleGraph.getModuleByUrl(modUrl);
+									if (mod) {
+										viteServer.moduleGraph.invalidateModule(mod);
+									}
+								} catch (e: any) {
+									// The server may be closed due to a restart caused by this file change
+									if (e.code === 'ERR_CLOSED_SERVER') break;
+									throw e;
 								}
 							}
 						}
diff --git a/packages/astro/src/core/module-loader/vite.ts b/packages/astro/src/core/module-loader/vite.ts
index f58b2e720c59..48ec230f078a 100644
--- a/packages/astro/src/core/module-loader/vite.ts
+++ b/packages/astro/src/core/module-loader/vite.ts
@@ -1,19 +1,52 @@
 import { EventEmitter } from 'node:events';
+import path from 'node:path';
 import type * as vite from 'vite';
 import type { ModuleLoader, ModuleLoaderEventEmitter } from './loader.js';
 
 export function createViteLoader(viteServer: vite.ViteDevServer): ModuleLoader {
 	const events = new EventEmitter() as ModuleLoaderEventEmitter;
 
-	viteServer.watcher.on('add', (...args) => events.emit('file-add', args));
-	viteServer.watcher.on('unlink', (...args) => events.emit('file-unlink', args));
-	viteServer.watcher.on('change', (...args) => events.emit('file-change', args));
+	let isTsconfigUpdated = false;
+	function isTsconfigUpdate(filePath: string) {
+		const result = path.basename(filePath) === 'tsconfig.json';
+		if (result) isTsconfigUpdated = true;
+		return result;
+	}
 
-	wrapMethod(viteServer.ws, 'send', (msg) => {
+	// Skip event emit on tsconfig change as Vite restarts the server, and we don't
+	// want to trigger unnecessary work that will be invalidated shortly.
+	viteServer.watcher.on('add', (...args) => {
+		if (!isTsconfigUpdate(args[0])) {
+			events.emit('file-add', args);
+		}
+	});
+	viteServer.watcher.on('unlink', (...args) => {
+		if (!isTsconfigUpdate(args[0])) {
+			events.emit('file-unlink', args);
+		}
+	});
+	viteServer.watcher.on('change', (...args) => {
+		if (!isTsconfigUpdate(args[0])) {
+			events.emit('file-change', args);
+		}
+	});
+
+	const _wsSend = viteServer.ws.send;
+	viteServer.ws.send = function (...args: any) {
+		// If the tsconfig changed, Vite will trigger a reload as it invalidates the module.
+		// However in Astro, the whole server is restarted when the tsconfig changes. If we
+		// do a restart and reload at the same time, the browser will refetch and the server
+		// is not ready yet, causing a blank page. Here we block that reload from happening.
+		if (isTsconfigUpdated) {
+			isTsconfigUpdated = false;
+			return;
+		}
+		const msg = args[0] as vite.HMRPayload;
 		if (msg?.type === 'error') {
 			events.emit('hmr-error', msg);
 		}
-	});
+		_wsSend.apply(this, args);
+	};
 
 	return {
 		import(src) {
@@ -56,11 +89,3 @@ export function createViteLoader(viteServer: vite.ViteDevServer): ModuleLoader {
 		events,
 	};
 }
-
-function wrapMethod(object: any, method: string, newFn: (...args: any[]) => void) {
-	const orig = object[method];
-	object[method] = function (...args: any[]) {
-		newFn.apply(this, args);
-		return orig.apply(this, args);
-	};
-}