diff --git a/drivers/serial/uart_cc13xx_cc26xx.c b/drivers/serial/uart_cc13xx_cc26xx.c
index 235782539f1c7d..fe35720c9abe0f 100644
--- a/drivers/serial/uart_cc13xx_cc26xx.c
+++ b/drivers/serial/uart_cc13xx_cc26xx.c
@@ -490,9 +490,6 @@ static const struct uart_driver_api uart_cc13xx_cc26xx_driver_api = {
 #endif /* CONFIG_UART_INTERRUPT_DRIVEN */
 };
 
-#define UART_CC13XX_CC26XX_DOMAIN_0 PRCM_DOMAIN_SERIAL
-#define UART_CC13XX_CC26XX_DOMAIN_1 PRCM_DOMAIN_PERIPH
-
 #ifdef CONFIG_SYS_POWER_MANAGEMENT
 #define UART_CC13XX_CC26XX_POWER_UART(n)				\
 	do {								\
@@ -500,7 +497,11 @@ static const struct uart_driver_api uart_cc13xx_cc26xx_driver_api = {
 		get_dev_data(dev)->tx_constrained = false;		\
 									\
 		/* Set Power dependencies */				\
-		Power_setDependency(PowerCC26XX_PERIPH_UART##n);	\
+		if (DT_INST_REG_ADDR(n) == 0x40001000) {		\
+			Power_setDependency(PowerCC26XX_PERIPH_UART0);	\
+		} else {						\
+			Power_setDependency(PowerCC26X2_PERIPH_UART1);	\
+		}							\
 									\
 		/* Register notification function */			\
 		Power_registerNotify(&get_dev_data(dev)->postNotify,	\
@@ -510,12 +511,21 @@ static const struct uart_driver_api uart_cc13xx_cc26xx_driver_api = {
 #else
 #define UART_CC13XX_CC26XX_POWER_UART(n)				\
 	do {								\
+		u32_t domain, periph;					\
+									\
 		/* Enable UART power domain */				\
-		PRCMPowerDomainOn(UART_CC13XX_CC26XX_DOMAIN_##n);	\
+		if (DT_INST_REG_ADDR(n) == 0x40001000) {		\
+			domain = PRCM_DOMAIN_SERIAL;			\
+			periph = PRCM_PERIPH_UART0;			\
+		} else {						\
+			domain = PRCM_DOMAIN_PERIPH;			\
+			periph = PRCM_PERIPH_UART1;			\
+		}							\
+		PRCMPowerDomainOn(domain);				\
 									\
 		/* Enable UART peripherals */				\
-		PRCMPeripheralRunEnable(PRCM_PERIPH_UART##n);		\
-		PRCMPeripheralSleepEnable(PRCM_PERIPH_UART##n);		\
+		PRCMPeripheralRunEnable(periph);			\
+		PRCMPeripheralSleepEnable(periph);			\
 									\
 		/* Load PRCM settings */				\
 		PRCMLoadSet();						\
@@ -524,8 +534,7 @@ static const struct uart_driver_api uart_cc13xx_cc26xx_driver_api = {
 		}							\
 									     \
 		/* UART should not be accessed until power domain is on. */  \
-		while (PRCMPowerDomainStatus(				     \
-			UART_CC13XX_CC26XX_DOMAIN_##n) !=		     \
+		while (PRCMPowerDomainStatus(domain) !=			     \
 			PRCM_DOMAIN_POWER_ON) {				     \
 			continue;					     \
 		}							     \
@@ -555,44 +564,24 @@ static const struct uart_driver_api uart_cc13xx_cc26xx_driver_api = {
 #define UART_CC13XX_CC26XX_INT_FIELDS
 #endif /* CONFIG_UART_INTERRUPT_DRIVEN */
 
-/*
- * DEVICE_DEFINE() requires the kernel level to be explicitly passed
- * using the actual macro name, hence we are forced to list these permutations
- * out.
- */
-#define UART_CC13XX_CC26XX_DEVICE_DEFINE_0				 \
-	DEVICE_DEFINE(uart_cc13xx_cc26xx_0, DT_INST_LABEL(0),		 \
-		uart_cc13xx_cc26xx_init_0,				 \
-		uart_cc13xx_cc26xx_pm_control,				 \
-		&uart_cc13xx_cc26xx_data_0, &uart_cc13xx_cc26xx_config_0,\
-		PRE_KERNEL_1, CONFIG_KERNEL_INIT_PRIORITY_DEVICE,	 \
-		&uart_cc13xx_cc26xx_driver_api)
-
-#define UART_CC13XX_CC26XX_DEVICE_DEFINE_1				 \
-	DEVICE_DEFINE(uart_cc13xx_cc26xx_1, DT_INST_LABEL(1),		 \
-		uart_cc13xx_cc26xx_init_1,				 \
-		uart_cc13xx_cc26xx_pm_control,				 \
-		&uart_cc13xx_cc26xx_data_1, &uart_cc13xx_cc26xx_config_1,\
-		POST_KERNEL, CONFIG_KERNEL_INIT_PRIORITY_DEVICE,	 \
-		&uart_cc13xx_cc26xx_driver_api)
-
-#define UART_CC13XX_CC26XX_DEVICE_API_INIT_0				 \
-	DEVICE_AND_API_INIT(uart_cc13xx_cc26xx_0, DT_INST_LABEL(0),	 \
-		uart_cc13xx_cc26xx_init_0, &uart_cc13xx_cc26xx_data_0,	 \
-		&uart_cc13xx_cc26xx_config_0, PRE_KERNEL_1,		 \
-		CONFIG_KERNEL_INIT_PRIORITY_DEVICE,			 \
+#define UART_CC13XX_CC26XX_DEVICE_DEFINE(n)				     \
+	DEVICE_DEFINE(uart_cc13xx_cc26xx_##n, DT_INST_LABEL(n),		     \
+		uart_cc13xx_cc26xx_init_##n,				     \
+		uart_cc13xx_cc26xx_pm_control,				     \
+		&uart_cc13xx_cc26xx_data_##n, &uart_cc13xx_cc26xx_config_##n,\
+		PRE_KERNEL_1, CONFIG_KERNEL_INIT_PRIORITY_DEVICE,	     \
 		&uart_cc13xx_cc26xx_driver_api)
 
-#define UART_CC13XX_CC26XX_DEVICE_API_INIT_1				 \
-	DEVICE_AND_API_INIT(uart_cc13xx_cc26xx_1, DT_INST_LABEL(1),	 \
-		uart_cc13xx_cc26xx_init_1, &uart_cc13xx_cc26xx_data_1,	 \
-		&uart_cc13xx_cc26xx_config_1, POST_KERNEL,		 \
-		CONFIG_KERNEL_INIT_PRIORITY_DEVICE,			 \
+#define UART_CC13XX_CC26XX_DEVICE_API_INIT(n)				     \
+	DEVICE_AND_API_INIT(uart_cc13xx_cc26xx_##n, DT_INST_LABEL(n),	     \
+		uart_cc13xx_cc26xx_init_##n, &uart_cc13xx_cc26xx_data_##n,   \
+		&uart_cc13xx_cc26xx_config_##n, PRE_KERNEL_1,		     \
+		CONFIG_KERNEL_INIT_PRIORITY_DEVICE,			     \
 		&uart_cc13xx_cc26xx_driver_api)
 
 #ifdef CONFIG_DEVICE_POWER_MANAGEMENT
 #define UART_CC13XX_CC26XX_DEVICE_INIT(n)				\
-	UART_CC13XX_CC26XX_DEVICE_DEFINE_##n
+	UART_CC13XX_CC26XX_DEVICE_DEFINE(n)
 
 #define UART_CC13XX_CC26XX_INIT_PM_STATE				\
 	do {								\
@@ -600,7 +589,7 @@ static const struct uart_driver_api uart_cc13xx_cc26xx_driver_api = {
 	} while (0)
 #else
 #define UART_CC13XX_CC26XX_DEVICE_INIT(n)				\
-	UART_CC13XX_CC26XX_DEVICE_API_INIT_##n
+	UART_CC13XX_CC26XX_DEVICE_API_INIT(n)
 
 #define UART_CC13XX_CC26XX_INIT_PM_STATE
 #endif