diff --git a/packages/react-native-renderer/src/ReactFabricGlobalResponderHandler.js b/packages/react-native-renderer/src/ReactFabricGlobalResponderHandler.js
index 12b6d1e92fcec..68a0b424ba34b 100644
--- a/packages/react-native-renderer/src/ReactFabricGlobalResponderHandler.js
+++ b/packages/react-native-renderer/src/ReactFabricGlobalResponderHandler.js
@@ -16,13 +16,7 @@ const ReactFabricGlobalResponderHandler = {
     const isFabric = !!fromOrTo.stateNode.canonical._internalInstanceHandle;
 
     if (isFabric) {
-      if (from) {
-        nativeFabricUIManager.setIsJSResponder(from.stateNode.node, false);
-      }
-
-      if (to) {
-        nativeFabricUIManager.setIsJSResponder(to.stateNode.node, true);
-      }
+      // Noop for now until setJSResponder/clearJSResponder are supported in Fabric
     } else {
       if (to !== null) {
         const tag = to.stateNode.canonical._nativeTag;
diff --git a/packages/react-native-renderer/src/__mocks__/react-native/Libraries/ReactPrivate/InitializeNativeFabricUIManager.js b/packages/react-native-renderer/src/__mocks__/react-native/Libraries/ReactPrivate/InitializeNativeFabricUIManager.js
index ee3c7df98508d..686dc72702de9 100644
--- a/packages/react-native-renderer/src/__mocks__/react-native/Libraries/ReactPrivate/InitializeNativeFabricUIManager.js
+++ b/packages/react-native-renderer/src/__mocks__/react-native/Libraries/ReactPrivate/InitializeNativeFabricUIManager.js
@@ -176,7 +176,6 @@ const RCTFabricUIManager = {
     );
     success(1, 1, 100, 100);
   }),
-  setIsJSResponder: jest.fn(),
 };
 
 global.nativeFabricUIManager = RCTFabricUIManager;
diff --git a/scripts/flow/react-native-host-hooks.js b/scripts/flow/react-native-host-hooks.js
index 29fed27e52c6b..17cc6fe9c952e 100644
--- a/scripts/flow/react-native-host-hooks.js
+++ b/scripts/flow/react-native-host-hooks.js
@@ -179,7 +179,6 @@ declare var nativeFabricUIManager: {
     locationY: number,
     callback: (Fiber) => void,
   ) => void,
-  setIsJSResponder: (node: Node, isJsResponder: boolean) => void,
   ...
 };