BioGears 6.3.0

What's new in ver 6.3 (March 1, 2018)

The latest deployment includes the following notable updates:

• General bug fixes, system improvements, and tools/solver improvements
• Fasciculation patient event flags
• Updated sweat methodology (fixes to ions lost in sweat)
• Updated substance and compound infusion functionality
  • Added Ringers lactate and updated
  • Saline compound ion concentrations corrected
  • Hardened implementation
• MuscleMass new patient data request
  • Muscle catabolism patient flag
• Added dehydration condition
  • Implemented as scalar 0to1 representing fractional total body water lost
  • Fluid removed from patient compartments
  • Updated patient flag for event and track body weight change (validated)
  • Added totalbodyfluidVolume as data request
  • Updated patient weight as a function of condition
• Added starvation condition
  • TimeSinceMeal determines how long since the patient's last meal
  • Scales internal nutrient storages from validated starvation data
  • Removed ConsumeMeal condition, now replaced by starvation condition
  • Validated blood concentrations for ketones, glucose, and amino acids
  • Updated patient weight as a function of condition
• Intracellular ion transport
  • Model uses membrane potential (see @ref TissueMethodology for details)
  • Michaelis coefficient could support more ion regulation in the future
  • Gated ion transport allows for differences between intra/extracellular spaces
• COPD now supports elevated anaerobic metabolism
• Ion transport model in the small intestine
• Updated drug library so all drugs support an effects site transport rate
• Diabetes type 1 and type 2 conditions
  • insulin resistance and insulin production effects
• Hemorrhage action now initialized with a 0-1 severity and a location (MCIS SDK example still exists)
• New drug Vasopressin
• New drug classifications in the CDM for better grouping in-code
  • Include anesthetic, sedative, opioid, and reversal agent
  • More grouping in future work