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CA1 pyramidal neuron: action potential backpropagation (Gasparini & Migliore 2015)

modeldb.science/148646

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Name		Name	Last commit message	Last commit date
Latest commit History 6 Commits
bAP.PNG		bAP.PNG
distr.mod		distr.mod
fixnseg.hoc		fixnseg.hoc
geoc81462.hoc		geoc81462.hoc
h.mod		h.mod
kadist.mod		kadist.mod
kaprox.mod		kaprox.mod
kdrca1.mod		kdrca1.mod
mosinit.hoc		mosinit.hoc
na3.mod		na3.mod
nax.mod		nax.mod
readme.html		readme.html
springer-bAP.hoc		springer-bAP.hoc
springer-bAPsyn.hoc		springer-bAPsyn.hoc
stdp.PNG		stdp.PNG

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<html>
  <p/>Model files for the Springer <a href="http://dx.doi.org/10.1007/978-1-4614-6675-8_123">Encyclopedia of Computational Neuroscience</a>
entry "Action potential Back-Propagation"
by Sonia Gasparini and Michele Migliore.
<p/><p/>The model shows how the back-propagation of action potentials 
in the dendrites of CA1 pyramidal neurons is modulated by
active conductances and synaptic inputs.
<p/><p/>The simulation file springer-bAP.hoc reproduces Fig.2 of the entry:
  <p/><img src="./bAP.PNG" alt="bAP screenshot" align="middle">
  <p/ align="left"><br/>
  A somatic AP is first elicited with a short current pulse.
Its peak amplitude as it backpropagates into the dendritic tree
is shown in the bottom panel at the end of the simulation.
Users can set the somatic peak conductance of the Na and KA currents
to see their effect on the AP backpropagation.
<p/><p/>springer-bAPsyn.hoc reproduces Fig.4 of the entry:
<p/><img src="./stdp.PNG" alt="STDP screenshot" align="middle"><p/>
    <p align="left">
      A somatic AP and a synaptic input are elicited with a relative delay.
The simulation shows the local mebrane potential of an oblique dendrite
at about 400 um from the soma under two different conditions: 
</p>
    <p/>(white) synaptic input is activated after the AP.
<p/>(red) synaptic input is activated before the AP.
<p/>Users can set the relative delay (in ms) 
to see its effect on the local membrane potential.
<p/>
<p/>Under unix systems:<br/>
to compile the mod files use the command 
nrnivmodl <br/>
and run the simulation file with the command 
nrngui filename
<p/><p/>Under Windows systems:<br/>
to compile the mod files use the "mknrndll" command.
A double click on a simulation file<br/>
  will open the simulation window. If you need more help running the model please consult this page:<br/>
  <a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide</a>
<p/><p/>Questions on how to use this model<br/>
should be directed to <a href="mailto:michele.migliore@cnr.it">michele.migliore@cnr.it</a>
<p/>



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