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Phenotype 1.1 (deprecated)
Covid-19 Phenotype Documentation, Version 1.1 (Last updated 4/14/2020)
Objective: To identify lab-confirmed, suspected, and possible cases of covid-19.
This phenotype will capture patients in four “tiers”: “lab-confirmed positive,” “lab-confirmed negative,” “probable positive,” and “possible positive.”
Note: The phenotype is specifically designed to include criteria that would be queryable in most clinical common data models (CDMs), including OMOP, PCORnet, ACT, and TriNetX. This may not enable inclusion of certain criteria that would otherwise be available (e.g., in a local data warehouse), such as temperature, O2 sat measurements, isolation flags, and information gleaned from clinical notes.
The University of North Carolina at Chapel Hill is planning to validate this draft phenotype through chart review. Results of this validation effort will be made public once complete. Other sites are also encouraged to validate against patient charts, especially because there may be regional differences in phenotype performance.
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Phenotype Rules
**Demographics and date criteria: **No age or demographic restrictions; use 1/1/2020 as the start date.
To identify “lab-confirmed positive cases”:
- Patient must have clear positive result from one or more of the labs listed in the Labs table, below.
To identify “lab-confirmed negative cases”:
- Patient must have a clear negative result from one or more of the labs listed in the Labs table, below.
_Note: _If patient has _both _a negative and a positive result within the timeframe of a single “run” of the phenotype, consider them a “lab-confirmed positive” case for the purpose of the phenotype, though both results will appear in the data for use in downstream analytics.
To identify “suspected positive” cases [GOAL: ~50% of patients in this category should actually have covid]:
- Patient must not be in the “lab-confirmed positive” or “lab-confirmed negative” categories and must have one or more of the following:
- One or more of the “strong positive” diagnosis codes from the Diagnosis table below (ICD or SNOMED)
- **OR **Unclear (null, uncertain, or incomplete) result from one or more of the labs listed in the Labs table, below.
- **OR **One or more of the HCPCS/CPT codes in the HCPCS/CPT table below, without an accompanying result record (may be waiting on result return)
To identify “possible positive” cases [GOAL: ~15% of patients in this category should actually have covid]:
- Patient must _not _be in the “lab-confirmed positive,” “lab-confirmed negative,” or “suspected positive” category and must have two or more different “weak positive” diagnosis codes from the Diagnosis table below (ICD or SNOMED), in the same encounter.
If a control group is needed, members of that group should not qualify for any of the above.
A patient should only be in one category at any given point in time but may move between categories. (E.g., a patient could be a “suspected positive” on Monday when their test is sent out and move to “lab-confirmed positive” by Friday when their test result comes back.)
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Labs
| LOINC Code | Name | Provenance |
| 94307-6 | SARS-CoV-2 N gene, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94308-4 | SARS-CoV-2 N gene, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94309-2 | SARS-CoV-2 RNA, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94310-0 | SARS-like CoV N gene, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94311-8 | SARS-CoV-2 N gene, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94312-6 | SARS-CoV-2 N gene, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94313-4 | SARS-like CoV N gene, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94314-2 | SARS-CoV-2 RdRp gene, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94315-9 | SARS-CoV-2 E gene, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94316-7 | SARS-CoV-2 N gene, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94500-6 | SARS-CoV-2 RNA, respiratory specimen | https://loinc.org/sars-coronavirus-2/ |
| 94502-2 | SARS-related CoV, respiratory specimen | https://loinc.org/sars-coronavirus-2/ |
| 94505-5 | SARS-CoV-2 IgG, serum or plasma | https://loinc.org/sars-coronavirus-2/ |
| 94506-3 | SARS-CoV-2 IgM, serum or plasma | https://loinc.org/sars-coronavirus-2/ |
| 94507-1 | SARS-CoV-2 IgG, serum or plasma | https://loinc.org/sars-coronavirus-2/ |
| 94508-9 | SARS-CoV-2 IgM, serum or plasma | https://loinc.org/sars-coronavirus-2/ |
| 94509-7 | SARS-CoV-2 E gene, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94510-5 | SARS-CoV-2 N gene, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94511-3 | SARS-CoV-2 ORF1ab region, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94532-9 | SARS-related CoV + MERS, respiratory specimen | https://loinc.org/sars-coronavirus-2/ |
| 94533-7 | SARS-CoV-2 N gene, respiratory specimen | https://loinc.org/sars-coronavirus-2/ |
| 94534-5 | SARS-CoV-2 RdRp gene, respiratory specimen | https://loinc.org/sars-coronavirus-2/ |
| 94547-7 | SARS-CoV-2 IgG + IgM, serum or plasma | https://loinc.org/sars-coronavirus-2/ |
| 94558-4 | SARS-CoV-2 Ag, respiratory specimen | https://loinc.org/sars-coronavirus-2/ |
| 94559-2 | SARS-CoV-2 ORF1ab region, respiratory specimen | https://loinc.org/sars-coronavirus-2/ |
| 94562-6 | SARS-CoV-2 IgA, serum or plasma | https://loinc.org/sars-coronavirus-2/ |
| 94563-4 | SARS-CoV-2 IgG, serum or plasma | https://loinc.org/sars-coronavirus-2/ |
| 94564-2 | SARS-CoV-2 IgM, serum or plasma | https://loinc.org/sars-coronavirus-2/ |
| 94565-9 | SARS-CoV-2 RNA, nasopharyngeal specimen | https://loinc.org/sars-coronavirus-2/ |
| 94639-2 | SARS-CoV-2 ORF1ab region, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94640-0 | SARS-CoV-2 S gene, respiratory specimen | https://loinc.org/sars-coronavirus-2/ |
| 94641-8 | SARS-CoV-2 S gene, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94642-6 | SARS-CoV-2 S gene, respiratory specimen | https://loinc.org/sars-coronavirus-2/ |
| 94643-4 | SARS-CoV-2 S gene, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94644-2 | SARS-CoV-2 ORF1ab region, respiratory specimen | https://loinc.org/sars-coronavirus-2/ |
| 94645-9 | SARS-CoV-2 RdRp gene, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94646-7 | SARS-CoV-2 RdRp gene, respiratory specimen | https://loinc.org/sars-coronavirus-2/ |
| 94647-5 | SARS-related CoV, unspecified specimen | https://loinc.org/sars-coronavirus-2/ |
| 94660-8 | SARS-CoV-2 RNA, serum/plasma | https://loinc.org/sars-coronavirus-2/ |
| 94661-6 | SARS-CoV-2 antibody interpretation | https://loinc.org/sars-coronavirus-2/ |
| NULL* | Upper(Name) LIKE ‘%COVID-19%’ |
*****For non-LOINC-coded covid lab tests at your institution, the string pattern to match in the name may be different then the one shown here. We encourage you to try different combinations per the naming practices at your site (“coronavirus,” “ncov,” “sars-cov,” etc.).
Diagnosis Codes
| ICD-10-CM Code | Diagnosis Name | Provenance (if known) | Confidence Level | Notes |
| B97.21 | SARS-associated coronavirus as the cause of diseases classified elsewhere | PCORnet | Strong positive | |
| B97.29 | Other coronavirus as the cause of diseases classified elsewhere | PCORnet; CDC coding guidance 2/2/2020 | Strong positive prior to 4/1/2020; weak positive after 4/1/2020 | |
| U07.1 | 2019-nCoV acute respiratory disease | PCORnet slide deck; https://www.who.int/classifications/icd/covid19/en/ | Strong positive | Code effective as of 4/1/2020 |
| Z20.828 | Contact with and (suspected) exposure to other viral communicable diseases | Weak positive | Exposure only | |
| B34.2 | Coronavirus infection, unspecified | Weak positive | CDC 2/2/2020 guidance specifically says NOT to use this code; however, likely appears in EHR code “pick lists” for covid | |
| R50* | Fever | PCORnet | Weak positive | |
| R05* | Cough | PCORnet | Weak positive | |
| R06.0* | Dyspnea | PCORnet | Weak positive | |
| J12*; J18* | Pneumonia | PCORnet | Weak positive | |
| J20*; J40* | Bronchitis (acute or nonspecified) | PCORnet | Weak positive | |
| J21* | Acute bronchiolitis | PCORnet | Weak positive | |
| J96* | Respiratory failure | PCORnet | Weak positive | |
| J22* | Unspecified acute lower respiratory infection | PCORnet | Weak positive | |
| J06.9 | Acute upper respiratory infection, unspecified | PCORnet | Weak positive | |
| J98.8 | Other specified respiratory disorders | PCORnet | Weak positive | |
| J80* | Acute respiratory distress syndrome | PCORnet | Weak positive | |
| R43.0 | Anosmia | Weak positive | ||
| R43.2 | Parageusia | Weak positive |
HCPCS/CPT Codes
| HCPCS/CPT Code | CPT Name | Provenance | Notes |
| U0001 | Coronavirus testing using the Centers for Disease Control and Prevention (CDC) 2019 Novel Coronavirus Real Time RT-PCR Diagnostic Test Panel | PCORnet | Effective date 2/4/2020 |
| U0002 | Validated non-CDC laboratory tests for SARS-CoV-2/2019-nCoV (COVID-19) | PCORnet | Effective date 2/4/2020 |
| 87635 | Infectious agent detection by nucleic acid (DNA or RNA); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]), amplified probe technique. | PCORnet | Effective date 3/13/2020 |
| 86318 | Infectious agent antibody | American Medical Association | Effective date 4/10/2020 |
| 86328 | IA NFCT AB SARSCOV2 COVID19 | American Medical Association | Effective date 4/10/2020 |
| 86769 | SARS-COV-2 COVID-19 ANTIBODY | American Medical Association | Effective date 4/10/2020 |
SNOMED codes
| SNOMED Code | Name | Provenance | Confidence Level |
| 840539006 | Disease caused by 2019 novel coronavirus (disorder) | OHDSI | Strong positive |
| 840544004 | Suspected disease caused by 2019 novel coronavirus (situation) | OHDSI | Strong positive |
OMOP-only codes (“emergency codes” used as placeholders; only applies to OMOP)
| OMOP Concept Code | Name | Provenance | Confidence Level |
| 756023 | Acute bronchitis caused by severe acute respiratory syndrome coronavirus 2 | https://github.com/OHDSI/Covid-19/wiki/Release | Strong positive |
| 756031 | Bronchitis caused by severe acute respiratory syndrome coronavirus 2 | https://github.com/OHDSI/Covid-19/wiki/Release | Strong positive |
| 756039 | Respiratory infection caused by severe acute respiratory syndrome coronavirus 2 | https://github.com/OHDSI/Covid-19/wiki/Release | Strong positive |
| 756044 | Acute respiratory distress syndrome (ARDS) caused by severe acute respiratory syndrome coronavirus 2 | https://github.com/OHDSI/Covid-19/wiki/Release | Strong positive |
| 756061 | Asymptomatic infection caused by severe acute respiratory syndrome coronavirus 2 | https://github.com/OHDSI/Covid-19/wiki/Release | Strong positive |
| 756081 | Infection of lower respiratory tract caused by severe acute respiratory syndrome coronavirus 2 | https://github.com/OHDSI/Covid-19/wiki/Release | Strong positive |
| 37310285 | Pneumonia caused by 2019 novel coronavirus | https://github.com/OHDSI/Covid-19/wiki/Release | Strong positive |